NEBIVOLOL HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2007)
Entry Type: Small molecule
Molecule Category: Salt
UNII: JGS34J7L9I
Parent Compound: NEBIVOLOL

Structure
InChI Key JWEXHQAEWHKGCW-UHFFFAOYSA-N
Smile Cl.OC(CNCC(O)C1CCc2cc(F)ccc2O1)C1CCc2cc(F)ccc2O1
InChI
InChI=1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H26ClF2NO4
Molecular Weight 441.9
AlogP 2.36
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 6.0
Polar Surface Area 70.95
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Beta-1 adrenergic receptor antagonist DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Parent
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Cardiac disorders
12.18
General disorders and administration site conditions
11.76
Nervous system disorders
11.38
Vascular disorders
9.0
Injury, poisoning and procedural complications
8.31
Gastrointestinal disorders
6.15
Respiratory, thoracic and mediastinal disorders
6.08
Investigations
5.99
Skin and subcutaneous tissue disorders
5.79
Psychiatric disorders
4.82
Musculoskeletal and connective tissue disorders
3.41
Metabolism and nutrition disorders
3.09
Immune system disorders
2.54

Cross References

Resources Reference
ChEMBL CHEMBL1201731
FDA SRS JGS34J7L9I
PubChem 24866733
SureChEMBL SCHEMBL514784
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