Trade Names: | |
Synonyms: | |
Status: | Approved (1953) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | J01XE01 |
UNII: | 927AH8112L |
InChI Key | NXFQHRVNIOXGAQ-YCRREMRBSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C8H6N4O5 |
Molecular Weight | 238.16 |
AlogP | 0.07 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 1.0 |
Number of Rotational Bond | 3.0 |
Polar Surface Area | 118.05 |
Molecular species | NEUTRAL |
Aromatic Rings | 1.0 |
Heavy Atoms | 17.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | DNA inhibitor | FDA |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Oxidoreductase
|
- | - | - | - | 41 | |
Enzyme
Protease
Serine protease
Serine protease PA clan
Serine protease S1A subfamily
|
- | - | - | - | 91 | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | -2-101 | |
Transporter
Primary active transporter
ATP-binding cassette
ABCC subfamily
|
- | 20900 | - | - | - | |
Unclassified protein
|
- | 19100 | - | 816 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Osteomyelitis | 0 | D010019 | ClinicalTrials |
Side effects | Relative Frequency (%) | Labels | |
---|---|---|---|
Gastrointestinal disorders Nausea | 8.0 | ||
Nervous system disorders Headache | 6.0 | ||
Gastrointestinal disorders Flatulence | 1.5 |
Resources | Reference |
---|---|
CAS NUMBER | 67-20-9 |
ChEBI | 71415 |
ChEMBL | CHEMBL572 |
DrugBank | DB00698 |
DrugCentral | 1949 |
FDA SRS | 927AH8112L |
Guide to Pharmacology | 10917 |
KEGG | C07268 |
PDB | U6Z |
PubChem | 6604200 |
SureChEMBL | SCHEMBL29470 |
ZINC | ZINC000003875368 |