| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1981) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | G59M7S0WS3 |
Structure
| InChI Key | SNIOPGDIGTZGOP-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C3H5N3O9 |
| Molecular Weight | 227.09 |
| AlogP | -1.02 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 157.11 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 15.0 |
Pharmacology
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Angina, Stable | 4 | D060050 | ClinicalTrials |
| Myocardial Infarction | 4 | D009203 | ClinicalTrials |
| Hypertension | 4 | D006973 | ClinicalTrials |
| Coronary Disease | 4 | D003327 | ClinicalTrials |
| Myocardial Ischemia | 3 | D017202 | ClinicalTrials |
| Stroke | 3 | D020521 | ClinicalTrials |
| Osteoporosis | 3 | D010024 | ClinicalTrials |
| Raynaud Disease | 3 | D011928 | ClinicalTrials |
| Wounds and Injuries | 3 | D014947 | ClinicalTrials |
| Arthritis, Rheumatoid | 3 | D001172 | ClinicalTrials |
| Muscle Cramp | 3 | D009120 | ClinicalTrials |
| Bone Diseases, Metabolic | 3 | D001851 | ClinicalTrials |
| Reperfusion Injury | 3 | D015427 | ClinicalTrials |
| Scleroderma, Localized | 3 | D012594 | ClinicalTrials |
| Hot Flashes | 2 | D019584 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
| Shock | 2 | D012769 | ClinicalTrials |
| Diabetic Neuropathies | 2 | D003929 | ClinicalTrials |
| Tendinopathy | 2 | D052256 | ClinicalTrials |
| Lung Neoplasms | 2 | D008175 | ClinicalTrials |
| Erectile Dysfunction | 2 | D007172 | ClinicalTrials |
| Hypertension, Pulmonary | 1 | D006976 | ClinicalTrials |
| Infections | 1 | D007239 | ClinicalTrials |
| Rectal Neoplasms | 1 | D012004 | ClinicalTrials |
| Phlebitis | 1 | D010689 | ClinicalTrials |
| Inflammation | 1 | D007249 | ClinicalTrials |
| Hypotension | 0 | D007022 | ClinicalTrials |
| Peripheral Arterial Disease | 0 | D058729 | ClinicalTrials |
| Colorectal Neoplasms | 0 | D015179 | ClinicalTrials |
Side Effects from Label
Side Effects (PT)
| Side effects | Relative Frequency (%) | Labels | |
|---|---|---|---|
| Nervous system disorders Headache | 63.0 | ||
| Nervous system disorders Headache | |||
| Cardiac disorders Dizziness | 6.0 | ||
| Cardiac disorders Dizziness | |||
| Cardiac disorders Dizziness | 4.0 | ||
| Vascular disorders Hypotension | 4.0 | ||
| Nervous system disorders Loss of consciousness | 4.0 | ||
| Vascular disorders Shock | 4.0 | ||
| Cardiac disorders Syncope | 4.0 | ||
| Nervous system disorders Headache | 3.0 | ||
| Cardiac disorders Angina pectoris | |||
| Cardiac disorders Angina pectoris | 2.0 |
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 55-63-0 |
| ChEBI | 28787 |
| ChEMBL | CHEMBL730 |
| DrugBank | DB00727 |
| DrugCentral | 1952 |
| EPA CompTox | DTXSID1021407 |
| FDA SRS | G59M7S0WS3 |
| Human Metabolome Database | HMDB0014865 |
| Guide to Pharmacology | 7053 |
| KEGG | C07455 |
| PDB | TNG |
| PharmGKB | PA450644 |
| PubChem | 4510 |
| SureChEMBL | SCHEMBL15421 |
| ZINC | ZINC000008214625 |
CONTENTS