OLSALAZINE SODIUM

Search structure
Trade Names:
Synonyms:
ADS
Status: Approved (1990)
Entry Type: Small molecule
Molecule Category: Salt Prodrug
UNII: Y7JEW0XG7I
Parent Compound: OLSALAZINE

Structure
InChI Key ZJEFYLVGGFISGT-VRZXRVJBSA-L
Smile O=C([O-])c1cc(/N=N/c2ccc(O)c(C(=O)[O-])c2)ccc1O.[Na+].[Na+]
InChI
InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-15+;;

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H8N2Na2O6
Molecular Weight 346.21
AlogP 2.91
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 4.0
Polar Surface Area 139.78
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Arachidonate 5-lipoxygenase inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 31.43
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -46.66-98.16

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
50.0
Immune system disorders
25.0
Musculoskeletal and connective tissue disorders
25.0

Cross References

Resources Reference
ChEMBL CHEMBL1201013
FDA SRS Y7JEW0XG7I
SureChEMBL SCHEMBL29767
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