OXALIPLATIN

Search structure
Trade Names:
Synonyms:
Status: Approved (2002)
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01XA03
UNII: 04ZR38536J

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H12N2O4Pt
Molecular Weight 395.27
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Biliary Tract Neoplasms 3 D001661 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Rectal Neoplasms 3 D012004 ClinicalTrials
Adenocarcinoma 3 D000230 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Carcinoma, Pancreatic Ductal 3 D021441 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Colonic Neoplasms 3 D003110 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Adenocarcinoma, Mucinous 3 D002288 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Testicular Neoplasms 3 D013736 ClinicalTrials
Hepatoblastoma 3 D018197 ClinicalTrials
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 3 D029424 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Teratoma 3 D013724 ClinicalTrials
Liver Neoplasms 3 D008113 ClinicalTrials
Biliary Tract Neoplasms 3 D001661 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Granuloma, Lethal Midline 3 D006103 ClinicalTrials
Colonic Neoplasms 3 D003110 ClinicalTrials
Rectal Neoplasms 3 D012004 ClinicalTrials
Carcinoma, Signet Ring Cell 3 D018279 ClinicalTrials
Neoplasm Metastasis 3 D009362 ClinicalTrials
Colorectal Neoplasms, Hereditary Nonpolyposis 3 D003123 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Carcinoma, Transitional Cell 2 D002295 ClinicalTrials
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Gallbladder Neoplasms 2 D005706 ClinicalTrials
Gallbladder Neoplasms 2 D005706 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Peripheral Nervous System Diseases 2 D010523 ClinicalTrials
Uterine Neoplasms 2 D014594 ClinicalTrials
Digestive System Neoplasms 2 D004067 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Carcinoma, Islet Cell 2 D018273 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell 2 D015459 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Anus Neoplasms 2 D001005 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 2 D009373 ClinicalTrials
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Gastrointestinal Stromal Tumors 1 D046152 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Carcinoid Tumor 1 D002276 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Hematologic Neoplasms 1 D019337 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Gliosarcoma 1 D018316 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Digestive System Diseases 1 D004066 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 1 D016410 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Side Effects from Label

Side effects Relative Frequency (%) Labels
Nervous system disorders Paraesthesia 92.0
Nervous system disorders Paraesthesia 91.9
Gastrointestinal disorders Vomiting 88.9
Gastrointestinal disorders Diarrhoea 85.9
Blood and lymphatic system disorders Anaemia 85.2
Blood and lymphatic system disorders Anaemia 83.8
Blood and lymphatic system disorders Neutropenia 82.2
Blood and lymphatic system disorders Anaemia 80.8
Blood and lymphatic system disorders Neutropenia 80.1
Blood and lymphatic system disorders Agranulocytosis 78.9
Blood and lymphatic system disorders Thrombocytopenia 77.4
Nervous system disorders Paraesthesia 77.2
Nervous system disorders Neuropathy peripheral 76.0
Blood and lymphatic system disorders Anaemia 75.6
Blood and lymphatic system disorders Thrombocytopenia 75.6
Blood and lymphatic system disorders Neutropenia 74.6
Blood and lymphatic system disorders Anaemia 74.0
Gastrointestinal disorders Nausea 73.7
Gastrointestinal disorders Nausea 72.2
Blood and lymphatic system disorders Thrombocytopenia 71.4
Gastrointestinal disorders Nausea 71.0
General disorders and administration site conditions Asthenia 70.3
General disorders and administration site conditions Fatigue 70.3
Blood and lymphatic system disorders Anaemia 68.0
Gastrointestinal disorders Nausea 67.2
Blood and lymphatic system disorders Anaemia 67.0
Nervous system disorders Paraesthesia 67.0
Blood and lymphatic system disorders Anaemia 66.9
Gastrointestinal disorders Diarrhoea 65.2
Blood and lymphatic system disorders Anaemia 64.0
Gastrointestinal disorders Nausea 64.0
Gastrointestinal disorders Vomiting 64.0
Gastrointestinal disorders Stomatitis 61.6
Gastrointestinal disorders Nausea 61.1
Blood and lymphatic system disorders Anaemia 61.0
General disorders and administration site conditions Asthenia 61.0
General disorders and administration site conditions Fatigue 61.0
Gastrointestinal disorders Nausea 61.0
Gastrointestinal disorders Nausea 59.0
Gastrointestinal disorders Stomatitis 59.0
Gastrointestinal disorders Diarrhoea 58.9
General disorders and administration site conditions Asthenia 58.2
General disorders and administration site conditions Fatigue 58.2
Gastrointestinal disorders Diarrhoea 56.3
Gastrointestinal disorders Diarrhoea 56.0
Blood and lymphatic system disorders Neutropenia 54.1
Gastrointestinal disorders Vomiting 54.1
Gastrointestinal disorders Nausea 53.4
Blood and lymphatic system disorders Neutropenia 53.0
General disorders and administration site conditions Asthenia 52.0
General disorders and administration site conditions Fatigue 52.0
Gastrointestinal disorders Diarrhoea 49.0
Gastrointestinal disorders Diarrhoea 48.4
Gastrointestinal disorders Diarrhoea 48.0
Gastrointestinal disorders Vomiting 47.2
Blood and lymphatic system disorders Neutropenia 46.1
Gastrointestinal disorders Diarrhoea 46.0
Nervous system disorders Paraesthesia 45.0
Skin and subcutaneous tissue disorders Alopecia 44.1
Gastrointestinal disorders Diarrhoea 44.0
Blood and lymphatic system disorders Neutropenia 44.0
Gastrointestinal disorders Stomatitis 44.0
Gastrointestinal disorders Diarrhoea 43.8
Gastrointestinal disorders Diarrhoea 43.4
Gastrointestinal disorders Vomiting 43.4
Blood and lymphatic system disorders Neutropenia 43.1
General disorders and administration site conditions Mucosal inflammation 42.1
Gastrointestinal disorders Stomatitis 42.1
Blood and lymphatic system disorders Neutropenia 41.0
Gastrointestinal disorders Vomiting 40.9
Blood and lymphatic system disorders Agranulocytosis 40.0
Blood and lymphatic system disorders Neutropenia 40.0
Gastrointestinal disorders Stomatitis 40.0
Blood and lymphatic system disorders Agranulocytosis 39.9
General disorders and administration site conditions Mucosal inflammation 39.7
Gastrointestinal disorders Stomatitis 39.7
Nervous system disorders Dysaesthesia pharynx 38.2
General disorders and administration site conditions Asthenia 38.0
General disorders and administration site conditions Fatigue 38.0
Skin and subcutaneous tissue disorders Alopecia 37.5
Gastrointestinal disorders Stomatitis 37.5
Gastrointestinal disorders Vomiting 37.0
Investigations Body temperature increased 36.0
Blood and lymphatic system disorders Neutropenia 36.0
Skin and subcutaneous tissue disorders Skin disorder 36.0
Gastrointestinal disorders Stomatitis 35.6
Skin and subcutaneous tissue disorders Skin disorder 35.5
Blood and lymphatic system disorders Leukopenia 35.0
Investigations Hepatic enzyme increased 34.0
Blood and lymphatic system disorders Leukopenia 34.0
Investigations Body temperature increased 33.0
Blood and lymphatic system disorders Neutropenia 33.0
Gastrointestinal disorders Stomatitis 32.0
Infections and infestations Infection 31.6
Skin and subcutaneous tissue disorders Skin disorder 31.5
Gastrointestinal disorders Abdominal pain 31.0
Gastrointestinal disorders Constipation 31.0
Gastrointestinal disorders Gastrointestinal pain 31.0
Blood and lymphatic system disorders Neutropenia 30.8
Blood and lymphatic system disorders Neutropenia 30.3
Skin and subcutaneous tissue disorders Alopecia 30.2
Blood and lymphatic system disorders Thrombocytopenia 30.0
Gastrointestinal disorders Vomiting 29.3
Gastrointestinal disorders Diarrhoea 29.0
Blood and lymphatic system disorders Agranulocytosis 28.8
Blood and lymphatic system disorders Thrombocytopenia 28.8
Gastrointestinal disorders Diarrhoea 28.5
Skin and subcutaneous tissue disorders Alopecia 28.1
Blood and lymphatic system disorders Anaemia 28.1
Skin and subcutaneous tissue disorders Alopecia 28.0
Blood and lymphatic system disorders Thrombocytopenia 28.0
Infections and infestations Infection 27.9
Investigations Body temperature increased 27.3
Blood and lymphatic system disorders Anaemia 27.0
Gastrointestinal disorders Vomiting 27.0
Blood and lymphatic system disorders Thrombocytopenia 26.2
Gastrointestinal disorders Vomiting 25.3
Infections and infestations Infection 25.2
Investigations Body temperature increased 25.0
Gastrointestinal disorders Diarrhoea 25.0
Infections and infestations Infection 25.0
Blood and lymphatic system disorders Neutropenia 25.0
Gastrointestinal disorders Stomatitis 25.0
Infections and infestations Infection 24.9
Blood and lymphatic system disorders Leukopenia 24.0
Gastrointestinal disorders Vomiting 24.0
General disorders and administration site conditions Asthenia 23.4
Investigations Body temperature increased 23.0
Gastrointestinal disorders Constipation 23.0
Infections and infestations Infection 23.0
Blood and lymphatic system disorders Leukopenia 23.0
Gastrointestinal disorders Vomiting 23.0
General disorders and administration site conditions Asthenia 21.6
Blood and lymphatic system disorders Leukopenia 21.0
Blood and lymphatic system disorders Thrombocytopenia 21.0
Investigations Blood alkaline phosphatase increased 20.0
General disorders and administration site conditions Decreased appetite 20.0
Blood and lymphatic system disorders Hyperbilirubinaemia 20.0
Blood and lymphatic system disorders Leukopenia 20.0
Nervous system disorders Paraesthesia 20.0
Blood and lymphatic system disorders Thrombocytopenia 20.0
Blood and lymphatic system disorders Leukopenia 19.5
Skin and subcutaneous tissue disorders Alopecia 19.2
Investigations Body temperature increased 19.0
Gastrointestinal disorders Constipation 19.0
Blood and lymphatic system disorders Leukopenia 19.0
Gastrointestinal disorders Nausea 19.0
Nervous system disorders Neuropathy peripheral 19.0
Blood and lymphatic system disorders Thrombocytopenia 19.0
Eye disorders Eye disorder 18.0
Eye disorders Lacrimation increased 18.0
Nervous system disorders Paraesthesia 18.0
Nervous system disorders Paraesthesia 17.8
Skin and subcutaneous tissue disorders Alopecia 17.7
Gastrointestinal disorders Abdominal pain 17.0
Gastrointestinal disorders Gastrointestinal pain 17.0
Nervous system disorders Neuropathy peripheral 17.0
Nervous system disorders Paraesthesia 16.7
Investigations Body temperature increased 16.2
Blood and lymphatic system disorders Neutropenia 16.2
General disorders and administration site conditions Asthenia 16.0
Musculoskeletal and connective tissue disorders Back pain 16.0
General disorders and administration site conditions Fatigue 16.0
Nervous system disorders Peripheral sensory neuropathy 16.0
Nervous system disorders Paraesthesia 15.6
Eye disorders Conjunctivitis 15.0
Gastrointestinal disorders Nausea 15.0
Investigations Body temperature increased 14.9
Blood and lymphatic system disorders Neutropenia 14.9
Gastrointestinal disorders Nausea 14.5
Blood and lymphatic system disorders Febrile neutropenia 14.0
General disorders and administration site conditions Pain 14.0
Gastrointestinal disorders Stomatitis 14.0
Blood and lymphatic system disorders Leukopenia 13.8
Blood and lymphatic system disorders Leukopenia 13.4
Gastrointestinal disorders Vomiting 13.3
Blood and lymphatic system disorders Anaemia 13.1
Respiratory, thoracic and mediastinal disorders Cough 13.0
Cardiac disorders Dyspnoea 13.0
Nervous system disorders Headache 13.0
Blood and lymphatic system disorders Leukopenia 13.0
General disorders and administration site conditions Oedema 13.0
Gastrointestinal disorders Vomiting 13.0
General disorders and administration site conditions Asthenia 12.9
General disorders and administration site conditions Fatigue 12.9
Nervous system disorders Paraesthesia 12.4
Blood and lymphatic system disorders Agranulocytosis 12.3
Investigations Body temperature increased 12.2
Investigations Body temperature increased 12.1
Investigations Body temperature increased 12.0
Gastrointestinal disorders Diarrhoea 12.0
Respiratory, thoracic and mediastinal disorders Epistaxis 12.0
Eye disorders Lacrimal disorder 12.0
Nervous system disorders Peripheral sensory neuropathy 12.0
Gastrointestinal disorders Diarrhoea 11.6
Nervous system disorders Paraesthesia 11.5
General disorders and administration site conditions Injection site reaction 11.1
Blood and lymphatic system disorders Anaemia 11.0
General disorders and administration site conditions Asthenia 11.0
Musculoskeletal and connective tissue disorders Back pain 11.0
Respiratory, thoracic and mediastinal disorders Cough 11.0
Metabolism and nutrition disorders Dehydration 11.0
Gastrointestinal disorders Diarrhoea 11.0
Cardiac disorders Dyspnoea 11.0
General disorders and administration site conditions Fatigue 11.0
Blood and lymphatic system disorders Febrile neutropenia 11.0
Infections and infestations Infection 11.0
Nervous system disorders Insomnia 11.0
Gastrointestinal disorders Nausea 11.0
Cardiac disorders Oedema peripheral 11.0
Skin and subcutaneous tissue disorders Skin exfoliation 11.0
Blood and lymphatic system disorders Anaemia 10.5
General disorders and administration site conditions Asthenia 10.5
General disorders and administration site conditions Fatigue 10.5
General disorders and administration site conditions Injection site reaction 10.4
Immune system disorders Hypersensitivity 10.3
Gastrointestinal disorders Stomatitis 10.1
Gastrointestinal disorders Abdominal pain 10.0
Musculoskeletal and connective tissue disorders Arthralgia 10.0
Respiratory, thoracic and mediastinal disorders Cough 10.0
Gastrointestinal disorders Dyspepsia 10.0
Gastrointestinal disorders Gastrointestinal pain 10.0
General disorders and administration site conditions Injection site reaction 10.0
General disorders and administration site conditions Mucosal inflammation 10.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 10.0
General disorders and administration site conditions Oedema 10.0
Gastrointestinal disorders Pharyngitis 10.0
Investigations Weight increased 10.0
Infections and infestations Infection 9.7
Blood and lymphatic system disorders Febrile neutropenia 9.3
Blood and lymphatic system disorders Agranulocytosis 9.0
General disorders and administration site conditions Asthenia 9.0
General disorders and administration site conditions Chills 9.0
Respiratory, thoracic and mediastinal disorders Cough 9.0
General disorders and administration site conditions Fatigue 9.0
Infections and infestations Infection 9.0
General disorders and administration site conditions Injection site reaction 9.0
Nervous system disorders Insomnia 9.0
General disorders and administration site conditions Pain 9.0
Gastrointestinal disorders Vomiting 9.0
Blood and lymphatic system disorders Anaemia 8.6
Investigations Body temperature increased 8.6
Blood and lymphatic system disorders Neutropenia 8.6
Blood and lymphatic system disorders Febrile neutropenia 8.5
Gastrointestinal disorders Diarrhoea 8.3
Gastrointestinal disorders Abdominal pain 8.0
General disorders and administration site conditions Decreased appetite 8.0
Cardiac disorders Dizziness 8.0
Gastrointestinal disorders Dysgeusia 8.0
Vascular disorders Embolism 8.0
Vascular disorders Embolism venous 8.0
Eye disorders Eye disorder 8.0
Gastrointestinal disorders Gastrointestinal pain 8.0
Nervous system disorders Headache 8.0
General disorders and administration site conditions Hyperhidrosis 8.0
Infections and infestations Infection 8.0
Eye disorders Lacrimal disorder 8.0
Eye disorders Lacrimation increased 8.0
Blood and lymphatic system disorders Neutropenia 8.0
Infections and infestations Rhinitis 8.0
Blood and lymphatic system disorders Febrile neutropenia 7.8
General disorders and administration site conditions Asthenia 7.2
General disorders and administration site conditions Fatigue 7.2
Blood and lymphatic system disorders Neutropenia 7.2
Investigations Body temperature increased 7.1
Blood and lymphatic system disorders Thrombocytopenia 7.1
Gastrointestinal disorders Abdominal pain 7.0
Blood and lymphatic system disorders Anaemia 7.0
Musculoskeletal and connective tissue disorders Arthralgia 7.0
General disorders and administration site conditions Asthenia 7.0
Metabolism and nutrition disorders Dehydration 7.0
Gastrointestinal disorders Diarrhoea 7.0
Cardiac disorders Dizziness 7.0
Gastrointestinal disorders Dyspepsia 7.0
Cardiac disorders Dyspnoea 7.0
General disorders and administration site conditions Fatigue 7.0
Gastrointestinal disorders Gastrointestinal pain 7.0
Infections and infestations Infection 7.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 7.0
Nervous system disorders Neuropathy peripheral 7.0
Blood and lymphatic system disorders Neutropenia 7.0
Gastrointestinal disorders Pharyngitis 7.0
Infections and infestations Rhinitis 7.0
Infections and infestations Upper respiratory tract infection 7.0
Blood and lymphatic system disorders Febrile neutropenia 6.7
General disorders and administration site conditions Asthenia 6.6
General disorders and administration site conditions Fatigue 6.6
Blood and lymphatic system disorders Anaemia 6.5
Vascular disorders Phlebitis 6.5
Vascular disorders Thrombosis 6.5
Gastrointestinal disorders Nausea 6.2
Psychiatric disorders Anxiety 6.0
General disorders and administration site conditions Asthenia 6.0
General disorders and administration site conditions Chills 6.0
Metabolism and nutrition disorders Dehydration 6.0
General disorders and administration site conditions Fatigue 6.0
Blood and lymphatic system disorders Febrile neutropenia 6.0
Gastrointestinal disorders Flatulence 6.0
Eye disorders Lacrimal disorder 6.0
Gastrointestinal disorders Nausea 6.0
Blood and lymphatic system disorders Neutropenia 6.0
Nervous system disorders Paraesthesia 6.0
Infections and infestations Rhinitis 6.0
Vascular disorders Thrombosis 6.0
Gastrointestinal disorders Vomiting 6.0
Gastrointestinal disorders Nausea 5.7
Vascular disorders Phlebitis 5.7
Gastrointestinal disorders Stomatitis 5.7
Vascular disorders Thrombosis 5.7
Gastrointestinal disorders Vomiting 5.7
Gastrointestinal disorders Diarrhoea 5.3
Gastrointestinal disorders Vomiting 5.3
Blood and lymphatic system disorders Thrombocytopenia 5.2
Gastrointestinal disorders Diarrhoea 5.1
Infections and infestations Infection 5.1
Gastrointestinal disorders Abdominal pain 5.0
Blood and lymphatic system disorders Agranulocytosis 5.0
Psychiatric disorders Anxiety 5.0
Investigations Body temperature increased 5.0
Cardiac disorders Chest pain 5.0
General disorders and administration site conditions Decreased appetite 5.0
Metabolism and nutrition disorders Dehydration 5.0
Psychiatric disorders Depression 5.0
Skin and subcutaneous tissue disorders Dermatitis 5.0
Gastrointestinal disorders Diarrhoea 5.0
Gastrointestinal disorders Dysgeusia 5.0
Gastrointestinal disorders Dyspepsia 5.0
Eye disorders Eye disorder 5.0
Gastrointestinal disorders Gastrointestinal pain 5.0
Nervous system disorders Headache 5.0
Blood and lymphatic system disorders Hyperbilirubinaemia 5.0
Infections and infestations Infection 5.0
General disorders and administration site conditions Injection site reaction 5.0
Nervous system disorders Insomnia 5.0
Eye disorders Lacrimation increased 5.0
Gastrointestinal disorders Nausea 5.0
Blood and lymphatic system disorders Neutropenia 5.0
Cardiac disorders Oedema peripheral 5.0
General disorders and administration site conditions Pain 5.0
Skin and subcutaneous tissue disorders Rash 5.0
Blood and lymphatic system disorders Thrombocytopenia 5.0
Vascular disorders Thrombosis 5.0
Infections and infestations Urinary tract infection 5.0
Gastrointestinal disorders Nausea 4.8
Blood and lymphatic system disorders Thrombocytopenia 4.8
Blood and lymphatic system disorders Thrombocytopenia 4.7
Blood and lymphatic system disorders Thrombocytopenia 4.6
Blood and lymphatic system disorders Anaemia 4.3
General disorders and administration site conditions Asthenia 4.3
Blood and lymphatic system disorders Thrombocytopenia 4.3
Gastrointestinal disorders Abdominal pain 4.0
Skin and subcutaneous tissue disorders Alopecia 4.0
Blood and lymphatic system disorders Anaemia 4.0
General disorders and administration site conditions Asthenia 4.0
Musculoskeletal and connective tissue disorders Back pain 4.0
Cardiac disorders Chest pain 4.0
Gastrointestinal disorders Constipation 4.0
General disorders and administration site conditions Decreased appetite 4.0
Metabolism and nutrition disorders Dehydration 4.0
Skin and subcutaneous tissue disorders Dermatitis 4.0
Gastrointestinal disorders Diarrhoea 4.0
Gastrointestinal disorders Dysgeusia 4.0
Cardiac disorders Dyspnoea 4.0
Vascular disorders Embolism 4.0
Vascular disorders Embolism venous 4.0
General disorders and administration site conditions Fatigue 4.0
Blood and lymphatic system disorders Febrile neutropenia 4.0
Gastrointestinal disorders Gastrointestinal pain 4.0
Renal and urinary disorders Haematuria 4.0
Blood and lymphatic system disorders Hyperbilirubinaemia 4.0
General disorders and administration site conditions Hyperhidrosis 4.0
Metabolism and nutrition disorders Hypokalaemia 4.0
Metabolism and nutrition disorders Hyponatraemia 4.0
Infections and infestations Infection 4.0
Nervous system disorders Insomnia 4.0
Gastrointestinal disorders Nausea 4.0
Skin and subcutaneous tissue disorders Rash 4.0
Infections and infestations Rhinitis 4.0
Infections and infestations Sinusitis 4.0
Gastrointestinal disorders Stomatitis 4.0
Blood and lymphatic system disorders Thrombocytopenia 4.0
Infections and infestations Upper respiratory tract infection 4.0
Infections and infestations Urinary tract infection 4.0
Gastrointestinal disorders Vomiting 4.0
Blood and lymphatic system disorders Agranulocytosis 3.7
Infections and infestations Infection 3.5
Gastrointestinal disorders Vomiting 3.5
General disorders and administration site conditions Asthenia 3.4
Blood and lymphatic system disorders Anaemia 3.3
Infections and infestations Infection 3.3
General disorders and administration site conditions Injection site reaction 3.1
Blood and lymphatic system disorders Agranulocytosis 3.0
Skin and subcutaneous tissue disorders Alopecia 3.0
Blood and lymphatic system disorders Anaemia 3.0
General disorders and administration site conditions Asthenia 3.0
Musculoskeletal and connective tissue disorders Back pain 3.0
General disorders and administration site conditions Decreased appetite 3.0
Metabolism and nutrition disorders Dehydration 3.0
Gastrointestinal disorders Diarrhoea 3.0
Gastrointestinal disorders Dysgeusia 3.0
Cardiac disorders Dyspnoea 3.0
Respiratory, thoracic and mediastinal disorders Epistaxis 3.0
Gastrointestinal disorders Flatulence 3.0
General disorders and administration site conditions Flushing 3.0
Gastrointestinal disorders Gastrooesophageal reflux disease 3.0
Renal and urinary disorders Haematuria 3.0
Endocrine disorders Hyperglycaemia 3.0
Immune system disorders Hypersensitivity 3.0
Metabolism and nutrition disorders Hypokalaemia 3.0
Vascular disorders Hypotension 3.0
Infections and infestations Infection 3.0
General disorders and administration site conditions Injection site reaction 3.0
General disorders and administration site conditions Pain 3.0
Infections and infestations Sinusitis 3.0
Gastrointestinal disorders Stomatitis 3.0
Blood and lymphatic system disorders Thrombocytopenia 3.0
Vascular disorders Thrombosis 3.0
General disorders and administration site conditions Mucosal inflammation 2.8
Gastrointestinal disorders Stomatitis 2.8
Blood and lymphatic system disorders Anaemia 2.7
Blood and lymphatic system disorders Thrombocytopenia 2.7
General disorders and administration site conditions Injection site reaction 2.6
Gastrointestinal disorders Diarrhoea 2.5
Blood and lymphatic system disorders Anaemia 2.4
Blood and lymphatic system disorders Thrombocytopenia 2.4
Immune system disorders Hypersensitivity 2.3
Infections and infestations Infection 2.3
Nervous system disorders Paraesthesia 2.3
General disorders and administration site conditions Mucosal inflammation 2.1
Gastrointestinal disorders Stomatitis 2.1
Gastrointestinal disorders Abdominal pain 2.0
Skin and subcutaneous tissue disorders Alopecia 2.0
Blood and lymphatic system disorders Anaemia 2.0
Gastrointestinal disorders Constipation 2.0
Respiratory, thoracic and mediastinal disorders Cough 2.0
General disorders and administration site conditions Decreased appetite 2.0
Gastrointestinal disorders Diarrhoea 2.0
Nervous system disorders Dysaesthesia 2.0
Cardiac disorders Dyspnoea 2.0
Renal and urinary disorders Dysuria 2.0
Vascular disorders Embolism 2.0
Vascular disorders Embolism venous 2.0
Respiratory, thoracic and mediastinal disorders Epistaxis 2.0
Blood and lymphatic system disorders Febrile neutropenia 2.0
General disorders and administration site conditions Flushing 2.0
Gastrointestinal disorders Gastrointestinal pain 2.0
Gastrointestinal disorders Gastrooesophageal reflux disease 2.0
Gastrointestinal disorders Hiccups 2.0
Endocrine disorders Hyperglycaemia 2.0
Immune system disorders Hypersensitivity 2.0
Hepatobiliary disorders Hypoalbuminaemia 2.0
Metabolism and nutrition disorders Hypokalaemia 2.0
Metabolism and nutrition disorders Hyponatraemia 2.0
Infections and infestations Infection 2.0
Blood and lymphatic system disorders Leukopenia 2.0
Blood and lymphatic system disorders Lymphopenia 2.0
General disorders and administration site conditions Mucosal inflammation 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Musculoskeletal and connective tissue disorders Myalgia 2.0
Gastrointestinal disorders Nausea 2.0
Nervous system disorders Neuropathy peripheral 2.0
Blood and lymphatic system disorders Neutropenia 2.0
General disorders and administration site conditions Pain 2.0
Nervous system disorders Paraesthesia 2.0
Gastrointestinal disorders Pharyngitis 2.0
Skin and subcutaneous tissue disorders Skin disorder 2.0
Skin and subcutaneous tissue disorders Skin exfoliation 2.0
Gastrointestinal disorders Stomatitis 2.0
Blood and lymphatic system disorders Thrombocytopenia 2.0
Infections and infestations Urinary tract infection 2.0
Gastrointestinal disorders Vomiting 2.0
Immune system disorders Hypersensitivity 1.9
Gastrointestinal disorders Nausea 1.9
Gastrointestinal disorders Vomiting 1.9
Vascular disorders Phlebitis 1.7
Skin and subcutaneous tissue disorders Skin disorder 1.7
Vascular disorders Thrombosis 1.7
Gastrointestinal disorders Diarrhoea 1.5
Nervous system disorders Dysaesthesia pharynx 1.5
Gastrointestinal disorders Nausea 1.5
Blood and lymphatic system disorders Thrombocytopenia 1.5
Skin and subcutaneous tissue disorders Skin disorder 1.4
Gastrointestinal disorders Stomatitis 1.4
Nervous system disorders Dysaesthesia pharynx 1.2
Blood and lymphatic system disorders Neutropenia 1.1
Blood and lymphatic system disorders Neutropenic sepsis 1.1
Gastrointestinal disorders Abdominal pain 1.0
Blood and lymphatic system disorders Agranulocytosis 1.0
Skin and subcutaneous tissue disorders Alopecia 1.0
Blood and lymphatic system disorders Anaemia 1.0
General disorders and administration site conditions Asthenia 1.0
Investigations Blood alkaline phosphatase increased 1.0
Investigations Body temperature increased 1.0
Cardiac disorders Chest pain 1.0
Eye disorders Conjunctivitis 1.0
Gastrointestinal disorders Constipation 1.0
Respiratory, thoracic and mediastinal disorders Cough 1.0
General disorders and administration site conditions Decreased appetite 1.0
Psychiatric disorders Depression 1.0
Nervous system disorders Dysaesthesia 1.0
Gastrointestinal disorders Dysgeusia 1.0
Cardiac disorders Dyspnoea 1.0
Renal and urinary disorders Dysuria 1.0
Vascular disorders Embolism 1.0
Vascular disorders Embolism venous 1.0
Respiratory, thoracic and mediastinal disorders Epistaxis 1.0
General disorders and administration site conditions Fatigue 1.0
Blood and lymphatic system disorders Febrile neutropenia 1.0
Gastrointestinal disorders Gastrointestinal pain 1.0
Gastrointestinal disorders Gastrooesophageal reflux disease 1.0
Renal and urinary disorders Haematuria 1.0
Nervous system disorders Headache 1.0
Investigations Hepatic enzyme increased 1.0
Gastrointestinal disorders Hiccups 1.0
Immune system disorders Hypersensitivity 1.0
Hepatobiliary disorders Hypoalbuminaemia 1.0
Metabolism and nutrition disorders Hypokalaemia 1.0
Metabolism and nutrition disorders Hyponatraemia 1.0
Infections and infestations Infection 1.0
General disorders and administration site conditions Injection site reaction 1.0
Nervous system disorders Insomnia 1.0
Eye disorders Lacrimal disorder 1.0
Blood and lymphatic system disorders Leukopenia 1.0
Blood and lymphatic system disorders Lymphopenia 1.0
Nervous system disorders Neuralgia 1.0
Blood and lymphatic system disorders Neutropenia 1.0
General disorders and administration site conditions Oedema 1.0
General disorders and administration site conditions Pain 1.0
Nervous system disorders Peripheral sensory neuropathy 1.0
Vascular disorders Phlebitis 1.0
Renal and urinary disorders Pollakiuria 1.0
Infections and infestations Rhinitis 1.0
Nervous system disorders Sensory disturbance 1.0
Skin and subcutaneous tissue disorders Skin exfoliation 1.0
Gastrointestinal disorders Stomatitis 1.0
Blood and lymphatic system disorders Thrombocytopenia 1.0
Vascular disorders Thrombosis 1.0
Infections and infestations Urinary tract infection 1.0
Eye disorders Visual impairment 1.0
Gastrointestinal disorders Vomiting 1.0
Investigations Weight increased 1.0
Gastrointestinal disorders Vomiting 0.9
Investigations Body temperature increased 0.8
Infections and infestations Infection 0.8
Gastrointestinal disorders Stomatitis 0.8
Blood and lymphatic system disorders Anaemia 0.7
Investigations Body temperature increased 0.7
Blood and lymphatic system disorders Febrile neutropenia 0.7
Infections and infestations Infection 0.7
Skin and subcutaneous tissue disorders Skin disorder 0.7
Immune system disorders Hypersensitivity 0.6
Infections and infestations Infection 0.6
Blood and lymphatic system disorders Neutropenic sepsis 0.6
Skin and subcutaneous tissue disorders Skin disorder 0.6
General disorders and administration site conditions Asthenia 0.5
General disorders and administration site conditions Fatigue 0.5
General disorders and administration site conditions Injection site reaction 0.5
Gastrointestinal disorders Vomiting 0.5
Investigations Body temperature increased 0.4
Blood and lymphatic system disorders Neutropenic sepsis 0.4
Blood and lymphatic system disorders Anaemia 0.3
Investigations Body temperature increased 0.3
Gastrointestinal disorders Nausea 0.3
Investigations Body temperature increased 0.2
General disorders and administration site conditions Injection site reaction 0.2
General disorders and administration site conditions Mucosal inflammation 0.2
Nervous system disorders Paraesthesia 0.2
Vascular disorders Phlebitis 0.2
Gastrointestinal disorders Stomatitis 0.2
Blood and lymphatic system disorders Thrombocytopenia 0.2
Vascular disorders Thrombosis 0.2
Blood and lymphatic system disorders Anaemia 0.1
Blood and lymphatic system disorders Febrile neutropenia 0.1
Immune system disorders Hypersensitivity 0.1
General disorders and administration site conditions Mucosal inflammation 0.1
Blood and lymphatic system disorders Neutropenic sepsis 0.1
Vascular disorders Phlebitis 0.1
Gastrointestinal disorders Stomatitis 0.1
Vascular disorders Thrombosis 0.1

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
11.54
General disorders and administration site conditions
11.14
Nervous system disorders
10.18
Vascular disorders
7.81
Respiratory, thoracic and mediastinal disorders
6.73
Blood and lymphatic system disorders
6.36
Skin and subcutaneous tissue disorders
6.26
Investigations
5.86
Cardiac disorders
4.89
Hepatobiliary disorders
4.29
Injury, poisoning and procedural complications
4.08
Metabolism and nutrition disorders
3.57
Infections and infestations
3.23
Immune system disorders
2.89
Psychiatric disorders
2.56
Musculoskeletal and connective tissue disorders
2.29
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.17

Cross References

Resources Reference
CAS NUMBER 61825-94-3
ChEMBL CHEMBL414804
FDA SRS 04ZR38536J
Guide to Pharmacology 7433
PubChem 9887054
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