Pharmacology

Action Mechanism of Action Reference
INHIBITOR Programmed cell death protein 1 inhibitor FDA
Primary Target
programmed cell death 1 (CD279)

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Melanoma 4 D008545 ClinicalTrials
Melanoma 4 D008545 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Melanoma 4 D008545 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Carcinoma, Merkel Cell 3 D015266 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Adenocarcinoma of Lung 3 D000077192 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Nasopharyngeal Neoplasms 3 D009303 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Breast Carcinoma In Situ 3 D000071960 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Small Cell Lung Carcinoma 3 D055752 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Multiple Myeloma 3 D009101 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Genital Neoplasms, Female 2 D005833 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Carcinoma, Adenoid Cystic 2 D003528 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Neurilemmoma 2 D009442 ClinicalTrials
Meningeal Neoplasms 2 D008577 ClinicalTrials
Mouth Neoplasms 2 D009062 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Breast Neoplasms, Male 2 D018567 ClinicalTrials
Sarcoma, Alveolar Soft Part 2 D018234 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Sezary Syndrome 2 D012751 ClinicalTrials
Inflammatory Breast Neoplasms 2 D058922 ClinicalTrials
Mycosis Fungoides 2 D009182 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Sarcoma, Kaposi 2 D012514 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Skin Neoplasms 2 D012878 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Waldenstrom Macroglobulinemia 2 D008258 ClinicalTrials
Neoplasm Metastasis 2 D009362 ClinicalTrials
Adrenal Cortex Neoplasms 2 D000306 ClinicalTrials
Oropharyngeal Neoplasms 2 D009959 ClinicalTrials
Leukoplakia, Oral 2 D007972 ClinicalTrials
Hereditary Breast and Ovarian Cancer Syndrome 2 D061325 ClinicalTrials
Hemangiosarcoma 2 D006394 ClinicalTrials
Pneumonia, Viral 2 D011024 ClinicalTrials
Penile Neoplasms 2 D010412 ClinicalTrials
Thyroid Carcinoma, Anaplastic 2 D065646 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Anus Neoplasms 2 D001005 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Papilloma 2 D010212 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Vulvar Neoplasms 2 D014846 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Neoplasm Metastasis 2 D009362 ClinicalTrials
Meningeal Carcinomatosis 2 D055756 ClinicalTrials
Anus Neoplasms 2 D001005 ClinicalTrials
Parotid Neoplasms 2 D010307 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Skin Neoplasms 2 D012878 ClinicalTrials
Skin Neoplasms 2 D012878 ClinicalTrials
Gallbladder Neoplasms 2 D005706 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Carcinoma, Medullary 2 D018276 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Granuloma, Lethal Midline 2 D006103 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Carcinoma in Situ 2 D002278 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Leukoplakia 2 D007971 ClinicalTrials
Gestational Trophoblastic Disease 2 D031901 ClinicalTrials
Scleroderma, Systemic 2 D012595 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Lymphoma, T-Cell, Peripheral 1 D016411 ClinicalTrials
Lymphoma, Mantle-Cell 1 D020522 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Uterine Neoplasms 1 D014594 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 1 D016410 ClinicalTrials
Leukemia, Biphenotypic, Acute 1 D015456 ClinicalTrials
Carcinoma, Basal Cell 1 D002280 ClinicalTrials
Liver Neoplasms 1 D008113 ClinicalTrials
Leukemia, Lymphoid 1 D007945 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials
Carcinoma, Intraductal, Noninfiltrating 0 D002285 ClinicalTrials
Smoldering Multiple Myeloma 0 D000075122 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
13.56
Respiratory, thoracic and mediastinal disorders
8.37
Injury, poisoning and procedural complications
7.68
Gastrointestinal disorders
7.22
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
6.63
Nervous system disorders
6.31
Skin and subcutaneous tissue disorders
5.45
Investigations
4.85
Immune system disorders
4.78
Musculoskeletal and connective tissue disorders
4.63
Metabolism and nutrition disorders
4.59
Vascular disorders
4.1
Cardiac disorders
3.87
Infections and infestations
3.75
Endocrine disorders
2.79
Psychiatric disorders
2.54
Hepatobiliary disorders
2.23

Cross References

Resources Reference
CAS NUMBER 1374853-91-4
ChEMBL CHEMBL3137343
FDA SRS DPT0O3T46P
Guide to Pharmacology 7499