PHENYTOIN SODIUM

Search structure
Trade Names:
Synonyms:
Status: Approved (1956)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 4182431BJH
Parent Compound: PHENYTOIN

Structure
InChI Key FJPYVLNWWICYDW-UHFFFAOYSA-M
Smile O=C1N=C([O-])NC1(c1ccccc1)c1ccccc1.[Na+]
InChI
InChI=1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H11N2NaO2
Molecular Weight 274.25
AlogP 1.97
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 61.69
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Sodium channel alpha subunit blocker PubMed PubMed FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 96

Metabolites

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Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
22.42
General disorders and administration site conditions
12.82
Injury, poisoning and procedural complications
9.89
Psychiatric disorders
8.31
Skin and subcutaneous tissue disorders
5.67
Immune system disorders
5.33
Investigations
5.17
Musculoskeletal and connective tissue disorders
4.89
Gastrointestinal disorders
3.9
Respiratory, thoracic and mediastinal disorders
3.3
Vascular disorders
3.15
Infections and infestations
3.11
Cardiac disorders
2.54
Eye disorders
2.06

Cross References

Resources Reference
ChEBI 8107
ChEMBL CHEMBL1611
EPA CompTox DTXSID2023775
FDA SRS 4182431BJH
Guide to Pharmacology 2624
KEGG C07443
PubChem 657302
SureChEMBL SCHEMBL3051683
ZINC ZINC02510358
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