PILOCARPINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1984)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 0WW6D218XJ
Parent Compound: PILOCARPINE

Structure
InChI Key RNAICSBVACLLGM-GNAZCLTHSA-N
Smile CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C.Cl
InChI
InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H17ClN2O2
Molecular Weight 244.72
AlogP 1.16
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 44.12
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Muscarinic acetylcholine receptor M1 agonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 20

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Head and Neck Neoplasms 3 D006258 ClinicalTrials

Related Entries

Scaffolds

Parent
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
18.14
Eye disorders
16.86
General disorders and administration site conditions
9.69
Psychiatric disorders
8.26
Vascular disorders
8.26
Gastrointestinal disorders
6.33
Skin and subcutaneous tissue disorders
6.33
Cardiac disorders
6.03
Respiratory, thoracic and mediastinal disorders
4.65
Injury, poisoning and procedural complications
4.1
Immune system disorders
2.72
Musculoskeletal and connective tissue disorders
2.62
Investigations
2.32

Cross References

Resources Reference
ChEBI 141029
ChEMBL CHEMBL1200330
EPA CompTox DTXSID2041096
FDA SRS 0WW6D218XJ
PubChem 5909
SureChEMBL SCHEMBL21643740
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