PIMECROLIMUS

Search structure
Trade Names:
Synonyms:
Status: Approved (2001)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: D11AH02
UNII: 7KYV510875

Structure
InChI Key KASDHRXLYQOAKZ-XDSKOBMDSA-N
Smile CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@H](Cl)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC
InChI
InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C43H68ClNO11
Molecular Weight 810.47
AlogP 5.72
Hydrogen Bond Acceptor 11.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 158.13
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 56.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR FK506-binding protein 1A inhibitor FDA
Primary Target
FKBP prolyl isomerase 1A
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 10000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Dermatitis, Atopic 4 D003876 ClinicalTrials
Dermatitis, Perioral 3 D019557 ClinicalTrials
Lichen Planus 3 D008010 ClinicalTrials
Dermatitis 3 D003872 ClinicalTrials
Dry Eye Syndromes 2 D015352 ClinicalTrials
Vitiligo 2 D014820 ClinicalTrials
Lichen Sclerosus et Atrophicus 2 D018459 ClinicalTrials
Dermatitis, Seborrheic 2 D012628 ClinicalTrials
Lichen Planus, Oral 2 D017676 ClinicalTrials
Netherton Syndrome 1 D056770 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Infections and infestations Nasopharyngitis 26.5
General disorders and administration site conditions Application site burn 25.9
General disorders and administration site conditions Application site pain 25.9
Nervous system disorders Headache 25.4
Nervous system disorders Nervous system disorder 25.4
Infections and infestations Nasopharyngitis 21.3
Infections and infestations Folliculitis 20.0
Infections and infestations Nasopharyngitis 19.6
Infections and infestations Infection 19.4
Infections and infestations Infestation 19.4
Infections and infestations Upper respiratory tract infection 19.4
Nervous system disorders Headache 16.0
Nervous system disorders Nervous system disorder 16.0
Respiratory, thoracic and mediastinal disorders Cough 15.8
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 15.8
General disorders and administration site conditions Application site reaction 14.6
Infections and infestations Infection 14.2
Infections and infestations Infestation 14.2
Infections and infestations Upper respiratory tract infection 14.2
Nervous system disorders Headache 13.9
Nervous system disorders Nervous system disorder 13.9
Infections and infestations Infection 13.2
Infections and infestations Infestation 13.2
Infections and infestations Influenza 13.2
Infections and infestations Upper respiratory tract infection 13.2
General disorders and administration site conditions Application site burn 12.5
General disorders and administration site conditions Application site pain 12.5
Investigations Body temperature increased 12.5
Investigations Body temperature increased 12.2
Respiratory, thoracic and mediastinal disorders Cough 11.6
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 11.6
Nervous system disorders Headache 11.3
Nervous system disorders Nervous system disorder 11.3
Infections and infestations Sinusitis 11.0
Infections and infestations Bronchitis 10.7
Respiratory, thoracic and mediastinal disorders Cough 10.7
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 10.7
General disorders and administration site conditions Application site burn 10.5
General disorders and administration site conditions Application site pain 10.5
General disorders and administration site conditions Application site burn 10.4
General disorders and administration site conditions Application site pain 10.4
Infections and infestations Nasopharyngitis 10.1
Infections and infestations Influenza 9.8
Infections and infestations Influenza 9.76
Infections and infestations Nasopharyngitis 9.55
Respiratory, thoracic and mediastinal disorders Cough 9.3
Respiratory, thoracic and mediastinal disorders Cough 9.25
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 9.25
Investigations Body temperature increased 8.82
Nervous system disorders Headache 8.82
Nervous system disorders Nervous system disorder 8.82
Investigations Body temperature increased 8.8
General disorders and administration site conditions Application site burn 8.5
General disorders and administration site conditions Application site pain 8.5
General disorders and administration site conditions Application site burn 8.46
General disorders and administration site conditions Application site pain 8.46
Respiratory, thoracic and mediastinal disorders Cough 8.1
Gastrointestinal disorders Oropharyngeal discomfort 8.1
Gastrointestinal disorders Oropharyngeal pain 8.1
Gastrointestinal disorders Pharyngitis 8.1
Respiratory, thoracic and mediastinal disorders Cough 8.09
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 8.09
Gastrointestinal disorders Oropharyngeal discomfort 8.09
Gastrointestinal disorders Oropharyngeal pain 8.09
Gastrointestinal disorders Pharyngitis 8.09
Infections and infestations Bronchitis 8.0
Infections and infestations Infection 8.0
Infections and infestations Infestation 8.0
Infections and infestations Upper respiratory tract infection 8.0
Gastrointestinal disorders Vomiting 8.0
Gastrointestinal disorders Diarrhoea 7.72
Gastrointestinal disorders Diarrhoea 7.7
Infections and infestations Nasopharyngitis 7.62
Infections and infestations Nasopharyngitis 7.6
Investigations Body temperature increased 7.5
Investigations Body temperature increased 7.49
Gastrointestinal disorders Gastroenteritis 7.4
Infections and infestations Nasopharyngitis 7.4
Gastrointestinal disorders Gastroenteritis 7.35
Infections and infestations Nasopharyngitis 7.35
Nervous system disorders Headache 7.01
Nervous system disorders Nervous system disorder 7.01
Gastrointestinal disorders Abdominal pain upper 6.7
General disorders and administration site conditions Application site burn 6.7
General disorders and administration site conditions Application site pain 6.7
Gastrointestinal disorders Nausea 6.7
Infections and infestations Rhinitis 6.7
Gastrointestinal disorders Abdominal pain upper 6.67
General disorders and administration site conditions Application site burn 6.67
General disorders and administration site conditions Application site pain 6.67
Gastrointestinal disorders Gastrointestinal disorder 6.67
Gastrointestinal disorders Nausea 6.67
Infections and infestations Rhinitis 6.67
Gastrointestinal disorders Diarrhoea 6.62
Infections and infestations Skin infection 6.62
Infections and infestations Viral infection 6.62
Gastrointestinal disorders Vomiting 6.62
Infections and infestations Influenza 6.6
Infections and infestations Viral infection 6.6
Gastrointestinal disorders Vomiting 6.6
Infections and infestations Influenza 6.57
General disorders and administration site conditions Application site irritation 6.4
Infections and infestations Skin infection 6.4
Infections and infestations Tonsillitis 6.3
Infections and infestations Tonsillitis 6.25
Infections and infestations Folliculitis 6.1
Infections and infestations Folliculitis 6.0
Infections and infestations Sinusitis 6.0
General disorders and administration site conditions Application site irritation 5.9
General disorders and administration site conditions Application site irritation 5.88
Infections and infestations Ear infection 5.7
Infections and infestations Ear infection 5.67
Gastrointestinal disorders Abdominal pain upper 5.51
Gastrointestinal disorders Gastrointestinal disorder 5.51
Gastrointestinal disorders Abdominal pain upper 5.5
General disorders and administration site conditions Application site pruritus 5.5
General disorders and administration site conditions Application site pruritus 5.49
Gastrointestinal disorders Oropharyngeal discomfort 5.4
Gastrointestinal disorders Oropharyngeal pain 5.4
Infections and infestations Skin infection 5.4
Infections and infestations Skin infection 5.37
Investigations Body temperature increased 5.33
Gastrointestinal disorders Diarrhoea 5.33
Infections and infestations Impetigo 5.33
Gastrointestinal disorders Oropharyngeal discomfort 5.33
Gastrointestinal disorders Oropharyngeal pain 5.33
Ear and labyrinth disorders Otitis media 5.33
Investigations Body temperature increased 5.3
Gastrointestinal disorders Diarrhoea 5.3
Infections and infestations Impetigo 5.3
Gastrointestinal disorders Oropharyngeal discomfort 5.3
Gastrointestinal disorders Oropharyngeal pain 5.3
Ear and labyrinth disorders Otitis media 5.3
General disorders and administration site conditions Application site reaction 5.15
Immune system disorders Hypersensitivity 5.15
Immune system disorders Immune system disorder 5.15
General disorders and administration site conditions Application site reaction 5.1
Immune system disorders Hypersensitivity 5.1
Infections and infestations Skin infection 5.1
General disorders and administration site conditions Application site burn 5.07
General disorders and administration site conditions Application site pain 5.07
Immune system disorders Hypersensitivity 4.8
Infections and infestations Infection 4.8
Immune system disorders Hypersensitivity 4.78
Immune system disorders Immune system disorder 4.78
Infections and infestations Infection 4.78
Infections and infestations Infestation 4.78
Infections and infestations Upper respiratory tract infection 4.78
Gastrointestinal disorders Oropharyngeal discomfort 4.48
Gastrointestinal disorders Oropharyngeal pain 4.48
Gastrointestinal disorders Abdominal pain 4.41
Gastrointestinal disorders Abdominal pain upper 4.41
Gastrointestinal disorders Gastrointestinal disorder 4.41
Gastrointestinal disorders Gastrointestinal pain 4.41
Immune system disorders Hypersensitivity 4.41
Immune system disorders Immune system disorder 4.41
Infections and infestations Rhinitis 4.41
Gastrointestinal disorders Vomiting 4.41
Gastrointestinal disorders Abdominal pain 4.4
Gastrointestinal disorders Abdominal pain upper 4.4
Gastrointestinal disorders Gastrointestinal pain 4.4
Immune system disorders Hypersensitivity 4.4
Infections and infestations Rhinitis 4.4
Gastrointestinal disorders Vomiting 4.4
Infections and infestations Infection 4.3
Infections and infestations Infection 4.27
Infections and infestations Infestation 4.27
Infections and infestations Upper respiratory tract infection 4.27
Gastrointestinal disorders Vomiting 4.2
Gastrointestinal disorders Vomiting 4.18
Gastrointestinal disorders Abdominal pain upper 4.12
Gastrointestinal disorders Gastrointestinal disorder 4.12
Immune system disorders Hypersensitivity 4.12
Immune system disorders Immune system disorder 4.12
Gastrointestinal disorders Abdominal pain upper 4.1
Immune system disorders Hypersensitivity 4.1
Infections and infestations Impetigo 4.04
Gastrointestinal disorders Nausea 4.04
Gastrointestinal disorders Abdominal pain 4.0
General disorders and administration site conditions Application site irritation 4.0
Eye disorders Conjunctivitis 4.0
Eye disorders Eye disorder 4.0
Infections and infestations Folliculitis 4.0
Gastrointestinal disorders Gastrointestinal pain 4.0
Infections and infestations Herpes simplex 4.0
Infections and infestations Impetigo 4.0
Infections and infestations Influenza 4.0
Gastrointestinal disorders Nausea 4.0
Infections and infestations Skin infection 4.0
Infections and infestations Varicella 4.0
Infections and infestations Herpes simplex 3.96
Immune system disorders Asthma 3.9
Immune system disorders Asthma 3.88
Immune system disorders Asthma 3.7
Gastrointestinal disorders Constipation 3.7
Gastrointestinal disorders Oropharyngeal discomfort 3.7
Gastrointestinal disorders Oropharyngeal pain 3.7
Infections and infestations Staphylococcal infection 3.7
Immune system disorders Asthma 3.68
Gastrointestinal disorders Constipation 3.68
Gastrointestinal disorders Oropharyngeal discomfort 3.68
Gastrointestinal disorders Oropharyngeal pain 3.68
Infections and infestations Staphylococcal infection 3.68
Gastrointestinal disorders Oropharyngeal discomfort 3.66
Gastrointestinal disorders Oropharyngeal pain 3.66
Infections and infestations Impetigo 3.6
Investigations Body temperature increased 3.58
Infections and infestations Impetigo 3.58
Immune system disorders Hypersensitivity 3.4
Gastrointestinal disorders Oropharyngeal discomfort 3.4
Gastrointestinal disorders Oropharyngeal pain 3.4
Gastrointestinal disorders Oropharyngeal discomfort 3.37
Gastrointestinal disorders Oropharyngeal pain 3.37
Immune system disorders Hypersensitivity 3.35
Immune system disorders Immune system disorder 3.35
General disorders and administration site conditions Application site reaction 3.31
Infections and infestations Ear infection 3.31
Respiratory, thoracic and mediastinal disorders Epistaxis 3.31
Infections and infestations Herpes simplex 3.31
Infections and infestations Skin papilloma 3.31
General disorders and administration site conditions Application site reaction 3.3
Immune system disorders Asthma 3.3
Infections and infestations Ear infection 3.3
Respiratory, thoracic and mediastinal disorders Epistaxis 3.3
Infections and infestations Herpes simplex 3.3
Infections and infestations Sinusitis 3.3
Infections and infestations Skin papilloma 3.3
Immune system disorders Asthma 3.28
Respiratory, thoracic and mediastinal disorders Cough 3.28
Infections and infestations Sinusitis 3.28
Eye disorders Conjunctivitis 3.05
Eye disorders Eye disorder 3.05
Gastrointestinal disorders Abdominal pain upper 3.0
General disorders and administration site conditions Application site irritation 3.0
General disorders and administration site conditions Application site reaction 3.0
Eye disorders Conjunctivitis 3.0
Infections and infestations Folliculitis 3.0
Infections and infestations Influenza 3.0
Ear and labyrinth disorders Otitis media 3.0
Infections and infestations Pharyngitis streptococcal 3.0
Infections and infestations Sinusitis 3.0
Infections and infestations Skin infection 3.0
Gastrointestinal disorders Vomiting 3.0
Gastrointestinal disorders Abdominal pain upper 2.99
Gastrointestinal disorders Gastrointestinal disorder 2.99
Ear and labyrinth disorders Otitis media 2.99
Infections and infestations Pharyngitis streptococcal 2.99
Ear and labyrinth disorders Ear pain 2.94
Ear and labyrinth disorders Otitis media 2.94
Infections and infestations Varicella 2.94
Ear and labyrinth disorders Ear pain 2.9
Ear and labyrinth disorders Otitis media 2.9
Infections and infestations Varicella 2.9
General disorders and administration site conditions Application site reaction 2.7
Immune system disorders Asthma 2.7
Ear and labyrinth disorders Ear pain 2.7
Gastrointestinal disorders Gastroenteritis 2.7
Infections and infestations Herpes simplex 2.7
General disorders and administration site conditions Influenza like illness 2.7
Gastrointestinal disorders Pharyngitis 2.7
General disorders and administration site conditions Application site reaction 2.67
Immune system disorders Asthma 2.67
Ear and labyrinth disorders Ear pain 2.67
Gastrointestinal disorders Gastroenteritis 2.67
Infections and infestations Herpes simplex 2.67
General disorders and administration site conditions Influenza like illness 2.67
Gastrointestinal disorders Pharyngitis 2.67
Respiratory, thoracic and mediastinal disorders Nasal congestion 2.62
Respiratory, thoracic and mediastinal disorders Nasal congestion 2.6
Infections and infestations Tonsillitis 2.6
Gastrointestinal disorders Toothache 2.6
Infections and infestations Tonsillitis 2.57
Gastrointestinal disorders Toothache 2.57
Immune system disorders Asthma 2.44
Infections and infestations Bronchitis 2.44
Respiratory, thoracic and mediastinal disorders Cough 2.44
Infections and infestations Impetigo 2.44
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 2.44
Immune system disorders Asthma 2.4
Infections and infestations Bronchitis 2.4
Respiratory, thoracic and mediastinal disorders Cough 2.4
Infections and infestations Impetigo 2.4
General disorders and administration site conditions Application site irritation 2.39
Infections and infestations Ear infection 2.25
Ear and labyrinth disorders Otitis media 2.25
General disorders and administration site conditions Application site erythema 2.21
Immune system disorders Asthma 2.21
Infections and infestations Bacterial infection 2.21
Infections and infestations Bronchitis 2.21
Eye disorders Conjunctivitis 2.21
Eye disorders Eye disorder 2.21
Infections and infestations Folliculitis 2.21
Gastrointestinal disorders Gastroenteritis 2.21
Infections and infestations Impetigo 2.21
Gastrointestinal disorders Nausea 2.21
Infections and infestations Sinusitis 2.21
Infections and infestations Skin infection 2.21
General disorders and administration site conditions Application site erythema 2.2
Immune system disorders Asthma 2.2
Infections and infestations Bacterial infection 2.2
Infections and infestations Bronchitis 2.2
Eye disorders Conjunctivitis 2.2
Infections and infestations Ear infection 2.2
Infections and infestations Folliculitis 2.2
Gastrointestinal disorders Gastroenteritis 2.2
Infections and infestations Impetigo 2.2
Gastrointestinal disorders Nausea 2.2
Ear and labyrinth disorders Otitis media 2.2
Infections and infestations Sinusitis 2.2
Infections and infestations Skin infection 2.2
General disorders and administration site conditions Application site erythema 2.13
Gastrointestinal disorders Diarrhoea 2.13
Infections and infestations Rhinitis 2.13
General disorders and administration site conditions Application site erythema 2.1
General disorders and administration site conditions Application site reaction 2.1
Eye disorders Conjunctivitis 2.1
Gastrointestinal disorders Diarrhoea 2.1
Infections and infestations Rhinitis 2.1
Infections and infestations Staphylococcal infection 2.1
General disorders and administration site conditions Application site reaction 2.09
Eye disorders Conjunctivitis 2.09
Eye disorders Eye disorder 2.09
Infections and infestations Staphylococcal infection 2.09
Infections and infestations Sinusitis 2.0
Infections and infestations Impetigo 1.9
Infections and infestations Nasopharyngitis 1.9
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 1.9
Infections and infestations Impetigo 1.87
Infections and infestations Nasopharyngitis 1.87
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 1.87
General disorders and administration site conditions Application site irritation 1.84
General disorders and administration site conditions Application site pruritus 1.84
Cardiac disorders Dyspnoea 1.84
General disorders and administration site conditions Influenza like illness 1.84
Infections and infestations Molluscum contagiosum 1.84
Skin and subcutaneous tissue disorders Acne 1.83
Musculoskeletal and connective tissue disorders Back pain 1.83
Infections and infestations Bacterial infection 1.83
Musculoskeletal and connective tissue disorders Bone disorder 1.83
Gastrointestinal disorders Gastroenteritis 1.83
General disorders and administration site conditions Influenza like illness 1.83
Gastrointestinal disorders Nausea 1.83
Gastrointestinal disorders Vomiting 1.83
Skin and subcutaneous tissue disorders Acne 1.8
General disorders and administration site conditions Application site pruritus 1.8
Musculoskeletal and connective tissue disorders Back pain 1.8
Infections and infestations Bacterial infection 1.8
Cardiac disorders Dyspnoea 1.8
Gastrointestinal disorders Gastroenteritis 1.8
General disorders and administration site conditions Influenza like illness 1.8
Infections and infestations Molluscum contagiosum 1.8
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.8
Gastrointestinal disorders Nausea 1.8
Gastrointestinal disorders Abdominal pain upper 1.79
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.79
Gastrointestinal disorders Vomiting 1.79
Gastrointestinal disorders Abdominal pain upper 1.52
General disorders and administration site conditions Application site burn 1.52
General disorders and administration site conditions Application site pain 1.52
Musculoskeletal and connective tissue disorders Arthralgia 1.52
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.52
Gastrointestinal disorders Nausea 1.52
Infections and infestations Rhinitis 1.52
Gastrointestinal disorders Abdominal pain 1.5
Skin and subcutaneous tissue disorders Acne 1.5
General disorders and administration site conditions Application site burn 1.5
General disorders and administration site conditions Application site pain 1.5
General disorders and administration site conditions Application site pruritus 1.5
Musculoskeletal and connective tissue disorders Arthralgia 1.5
Immune system disorders Asthma 1.5
Musculoskeletal and connective tissue disorders Back pain 1.5
Infections and infestations Bacterial infection 1.5
Infections and infestations Bronchitis 1.5
Reproductive system and breast disorders Dysmenorrhoea 1.5
Infections and infestations Ear infection 1.5
Gastrointestinal disorders Gastrointestinal pain 1.5
Infections and infestations Herpes dermatitis 1.5
Laceration 1.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.5
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.5
Gastrointestinal disorders Pharyngitis 1.5
Infections and infestations Pharyngitis streptococcal 1.5
Infections and infestations Pneumonia 1.5
Infections and infestations Rhinitis 1.5
Infections and infestations Tracheobronchitis 1.5
Infections and infestations Viral upper respiratory tract infection 1.5
Gastrointestinal disorders Abdominal pain 1.49
General disorders and administration site conditions Application site burn 1.49
General disorders and administration site conditions Application site pain 1.49
Reproductive system and breast disorders Breast disorder 1.49
Reproductive system and breast disorders Dysmenorrhoea 1.49
Gastrointestinal disorders Gastrointestinal pain 1.49
Laceration 1.49
Gastrointestinal disorders Oropharyngeal discomfort 1.49
Gastrointestinal disorders Oropharyngeal pain 1.49
Infections and infestations Pneumonia 1.49
Infections and infestations Rhinitis 1.49
Skin and subcutaneous tissue disorders Acne 1.47
General disorders and administration site conditions Application site pruritus 1.47
Musculoskeletal and connective tissue disorders Back pain 1.47
Musculoskeletal and connective tissue disorders Bone disorder 1.47
Infections and infestations Bronchitis 1.47
Infections and infestations Ear infection 1.47
Infections and infestations Herpes dermatitis 1.47
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.47
Gastrointestinal disorders Pharyngitis 1.47
Infections and infestations Pharyngitis streptococcal 1.47
Infections and infestations Tracheobronchitis 1.47
Infections and infestations Viral upper respiratory tract infection 1.47
Musculoskeletal and connective tissue disorders Arthralgia 1.33
Immune system disorders Asthma 1.33
Reproductive system and breast disorders Breast disorder 1.33
Reproductive system and breast disorders Dysmenorrhoea 1.33
Cardiac disorders Dyspnoea 1.33
Infections and infestations Ear infection 1.33
Respiratory, thoracic and mediastinal disorders Epistaxis 1.33
Immune system disorders Hypersensitivity 1.33
Immune system disorders Immune system disorder 1.33
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.33
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.33
Infections and infestations Nasopharyngitis 1.33
Infections and infestations Pneumonia 1.33
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 1.33
Infections and infestations Sinusitis 1.33
Gastrointestinal disorders Toothache 1.33
Infections and infestations Viral infection 1.33
Musculoskeletal and connective tissue disorders Arthralgia 1.3
Immune system disorders Asthma 1.3
Reproductive system and breast disorders Dysmenorrhoea 1.3
Cardiac disorders Dyspnoea 1.3
Infections and infestations Ear infection 1.3
Respiratory, thoracic and mediastinal disorders Epistaxis 1.3
Immune system disorders Hypersensitivity 1.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.3
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.3
Infections and infestations Nasopharyngitis 1.3
Infections and infestations Pneumonia 1.3
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 1.3
Infections and infestations Sinusitis 1.3
Gastrointestinal disorders Toothache 1.3
Infections and infestations Viral infection 1.3
Investigations Body temperature increased 1.22
Reproductive system and breast disorders Breast disorder 1.22
Gastrointestinal disorders Diarrhoea 1.22
Reproductive system and breast disorders Dysmenorrhoea 1.22
Gastrointestinal disorders Oropharyngeal discomfort 1.22
Gastrointestinal disorders Oropharyngeal pain 1.22
Infections and infestations Bacterial infection 1.2
Investigations Body temperature increased 1.2
Infections and infestations Bronchitis 1.2
Gastrointestinal disorders Diarrhoea 1.2
Reproductive system and breast disorders Dysmenorrhoea 1.2
Infections and infestations Herpes simplex 1.2
Infections and infestations Molluscum contagiosum 1.2
Gastrointestinal disorders Nausea 1.2
Respiratory, thoracic and mediastinal disorders Wheezing 1.2
Infections and infestations Bacterial infection 1.19
Infections and infestations Bronchitis 1.19
Gastrointestinal disorders Diarrhoea 1.19
Infections and infestations Herpes simplex 1.19
Infections and infestations Molluscum contagiosum 1.19
Gastrointestinal disorders Nausea 1.19
Respiratory, thoracic and mediastinal disorders Wheezing 1.19
General disorders and administration site conditions Application site pruritus 1.12
Reproductive system and breast disorders Breast disorder 1.12
Gastrointestinal disorders Diarrhoea 1.12
Reproductive system and breast disorders Dysmenorrhoea 1.12
Infections and infestations Folliculitis 1.12
Infections and infestations Pneumonia 1.12
Respiratory, thoracic and mediastinal disorders Sinus congestion 1.12
Infections and infestations Sinusitis 1.12
Immune system disorders Urticaria 1.12
General disorders and administration site conditions Application site pruritus 1.1
Musculoskeletal and connective tissue disorders Arthralgia 1.1
Immune system disorders Asthma 1.1
Infections and infestations Bacterial infection 1.1
Reproductive system and breast disorders Breast disorder 1.1
Gastrointestinal disorders Diarrhoea 1.1
Reproductive system and breast disorders Dysmenorrhoea 1.1
Eye disorders Eye infection 1.1
Infections and infestations Folliculitis 1.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.1
Infections and infestations Pneumonia 1.1
Respiratory, thoracic and mediastinal disorders Sinus congestion 1.1
Infections and infestations Sinusitis 1.1
Immune system disorders Urticaria 1.1
Skin and subcutaneous tissue disorders Acne 1.0
Musculoskeletal and connective tissue disorders Back pain 1.0
Musculoskeletal and connective tissue disorders Bone disorder 1.0
Gastrointestinal disorders Constipation 1.0
Gastrointestinal disorders Diarrhoea 1.0
Eye disorders Eye infection 1.0
Infections and infestations Folliculitis 1.0
Laceration 1.0
Infections and infestations Pharyngitis streptococcal 1.0
Respiratory, thoracic and mediastinal disorders Sinus congestion 1.0
Infections and infestations Sinusitis 1.0
Infections and infestations Skin papilloma 1.0
Infections and infestations Staphylococcal infection 1.0
Immune system disorders Urticaria 1.0
Respiratory, thoracic and mediastinal disorders Wheezing 1.0
Gastrointestinal disorders Abdominal pain 0.915
General disorders and administration site conditions Application site irritation 0.915
Eye disorders Conjunctivitis 0.915
Gastrointestinal disorders Gastrointestinal pain 0.915
Gastrointestinal disorders Pharyngitis 0.915
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.915
Infections and infestations Staphylococcal infection 0.915
Immune system disorders Urticaria 0.915
General disorders and administration site conditions Application site irritation 0.9
Infections and infestations Folliculitis 0.9
Infections and infestations Nasopharyngitis 0.9
Gastrointestinal disorders Pharyngitis 0.9
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.9
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.9
Infections and infestations Staphylococcal infection 0.9
Infections and infestations Tonsillitis 0.9
Immune system disorders Urticaria 0.9
Infections and infestations Varicella 0.9
Infections and infestations Viral upper respiratory tract infection 0.9
General disorders and administration site conditions Application site irritation 0.896
Immune system disorders Asthma 0.896
Infections and infestations Folliculitis 0.896
Infections and infestations Nasopharyngitis 0.896
Gastrointestinal disorders Nausea 0.896
Gastrointestinal disorders Pharyngitis 0.896
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.896
Infections and infestations Tonsillitis 0.896
Infections and infestations Varicella 0.896
Infections and infestations Viral upper respiratory tract infection 0.896
Immune system disorders Asthma 0.749
Eye disorders Conjunctivitis 0.749
Ear and labyrinth disorders Ear pain 0.749
Eye disorders Eye disorder 0.749
Laceration 0.749
Infections and infestations Molluscum contagiosum 0.749
Gastrointestinal disorders Pharyngitis 0.749
Infections and infestations Pharyngitis streptococcal 0.749
Infections and infestations Varicella 0.749
Infections and infestations Viral infection 0.749
Gastrointestinal disorders Abdominal pain 0.735
Skin and subcutaneous tissue disorders Acne 0.735
Immune system disorders Asthma 0.735
Eye disorders Conjunctivitis 0.735
Gastrointestinal disorders Diarrhoea 0.735
Ear and labyrinth disorders Ear pain 0.735
Respiratory, thoracic and mediastinal disorders Epistaxis 0.735
Eye disorders Eye disorder 0.735
Infections and infestations Folliculitis 0.735
Gastrointestinal disorders Gastrointestinal pain 0.735
Infections and infestations Influenza 0.735
Laceration 0.735
Infections and infestations Nasopharyngitis 0.735
Ear and labyrinth disorders Otitis media 0.735
Infections and infestations Pneumonia 0.735
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.735
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.735
Infections and infestations Sinusitis 0.735
Gastrointestinal disorders Toothache 0.735
Infections and infestations Viral infection 0.735
Respiratory, thoracic and mediastinal disorders Wheezing 0.735
Gastrointestinal disorders Abdominal pain 0.7
Skin and subcutaneous tissue disorders Acne 0.7
Immune system disorders Asthma 0.7
Eye disorders Conjunctivitis 0.7
Gastrointestinal disorders Diarrhoea 0.7
Ear and labyrinth disorders Ear pain 0.7
Respiratory, thoracic and mediastinal disorders Epistaxis 0.7
Infections and infestations Folliculitis 0.7
Gastrointestinal disorders Gastrointestinal pain 0.7
Infections and infestations Influenza 0.7
Laceration 0.7
Infections and infestations Molluscum contagiosum 0.7
Infections and infestations Nasopharyngitis 0.7
Ear and labyrinth disorders Otitis media 0.7
Gastrointestinal disorders Pharyngitis 0.7
Infections and infestations Pharyngitis streptococcal 0.7
Infections and infestations Pneumonia 0.7
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.7
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.7
Infections and infestations Sinusitis 0.7
Gastrointestinal disorders Toothache 0.7
Infections and infestations Varicella 0.7
Infections and infestations Viral infection 0.7
Respiratory, thoracic and mediastinal disorders Wheezing 0.7
General disorders and administration site conditions Application site reaction 0.61
Immune system disorders Asthma 0.61
Cardiac disorders Dyspnoea 0.61
Infections and infestations Ear infection 0.61
Ear and labyrinth disorders Ear pain 0.61
Infections and infestations Herpes dermatitis 0.61
General disorders and administration site conditions Influenza like illness 0.61
Respiratory, thoracic and mediastinal disorders Nasal congestion 0.61
Ear and labyrinth disorders Otitis media 0.61
Infections and infestations Sinusitis 0.61
Infections and infestations Tonsillitis 0.61
Gastrointestinal disorders Toothache 0.61
Gastrointestinal disorders Vomiting 0.61
General disorders and administration site conditions Application site pruritus 0.6
Gastrointestinal disorders Constipation 0.6
Gastrointestinal disorders Diarrhoea 0.6
Cardiac disorders Dyspnoea 0.6
Infections and infestations Ear infection 0.6
Gastrointestinal disorders Gastroenteritis 0.6
Infections and infestations Herpes dermatitis 0.6
General disorders and administration site conditions Influenza like illness 0.6
Respiratory, thoracic and mediastinal disorders Nasal congestion 0.6
Ear and labyrinth disorders Otitis media 0.6
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.6
Infections and infestations Sinusitis 0.6
Infections and infestations Skin papilloma 0.6
Infections and infestations Tonsillitis 0.6
Gastrointestinal disorders Toothache 0.6
Gastrointestinal disorders Vomiting 0.6
General disorders and administration site conditions Application site pruritus 0.597
Musculoskeletal and connective tissue disorders Back pain 0.597
Gastrointestinal disorders Constipation 0.597
Gastrointestinal disorders Diarrhoea 0.597
Gastrointestinal disorders Gastroenteritis 0.597
General disorders and administration site conditions Influenza like illness 0.597
Respiratory, thoracic and mediastinal disorders Nasal congestion 0.597
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.597
Infections and infestations Skin papilloma 0.597
Gastrointestinal disorders Toothache 0.597
Gastrointestinal disorders Abdominal pain 0.4
General disorders and administration site conditions Application site erythema 0.4
General disorders and administration site conditions Application site irritation 0.4
Musculoskeletal and connective tissue disorders Back pain 0.4
Infections and infestations Bronchitis 0.4
Gastrointestinal disorders Constipation 0.4
Gastrointestinal disorders Gastrointestinal pain 0.4
Infections and infestations Herpes simplex 0.4
General disorders and administration site conditions Influenza like illness 0.4
Infections and infestations Nasopharyngitis 0.4
Gastrointestinal disorders Nausea 0.4
Infections and infestations Rhinitis 0.4
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.4
Infections and infestations Skin papilloma 0.4
Infections and infestations Staphylococcal infection 0.4
Infections and infestations Tonsillitis 0.4
Gastrointestinal disorders Toothache 0.4
Immune system disorders Urticaria 0.4
Infections and infestations Viral upper respiratory tract infection 0.4
Respiratory, thoracic and mediastinal disorders Wheezing 0.4
Gastrointestinal disorders Abdominal pain 0.375
General disorders and administration site conditions Application site erythema 0.375
Musculoskeletal and connective tissue disorders Back pain 0.375
Musculoskeletal and connective tissue disorders Bone disorder 0.375
Infections and infestations Bronchitis 0.375
Gastrointestinal disorders Constipation 0.375
Gastrointestinal disorders Gastrointestinal pain 0.375
Infections and infestations Herpes simplex 0.375
General disorders and administration site conditions Influenza like illness 0.375
Gastrointestinal disorders Nausea 0.375
Infections and infestations Rhinitis 0.375
Infections and infestations Skin papilloma 0.375
Infections and infestations Staphylococcal infection 0.375
Infections and infestations Tonsillitis 0.375
Gastrointestinal disorders Toothache 0.375
Infections and infestations Viral upper respiratory tract infection 0.375
Respiratory, thoracic and mediastinal disorders Wheezing 0.375
General disorders and administration site conditions Application site irritation 0.368
Infections and infestations Nasopharyngitis 0.368
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.368
Immune system disorders Urticaria 0.368
Gastrointestinal disorders Abdominal pain 0.305
Gastrointestinal disorders Abdominal pain upper 0.305
Musculoskeletal and connective tissue disorders Arthralgia 0.305
Immune system disorders Asthma 0.305
Reproductive system and breast disorders Dysmenorrhoea 0.305
Cardiac disorders Dyspnoea 0.305
Respiratory, thoracic and mediastinal disorders Epistaxis 0.305
Eye disorders Eye infection 0.305
Gastrointestinal disorders Gastrointestinal disorder 0.305
Gastrointestinal disorders Gastrointestinal pain 0.305
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.305
Respiratory, thoracic and mediastinal disorders Nasal congestion 0.305
Infections and infestations Nasopharyngitis 0.305
Infections and infestations Pneumonia 0.305
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.305
Gastrointestinal disorders Toothache 0.305
Infections and infestations Varicella 0.305
Infections and infestations Viral upper respiratory tract infection 0.305
Gastrointestinal disorders Abdominal pain 0.3
Gastrointestinal disorders Abdominal pain upper 0.3
Skin and subcutaneous tissue disorders Acne 0.3
Musculoskeletal and connective tissue disorders Arthralgia 0.3
Musculoskeletal and connective tissue disorders Back pain 0.3
Respiratory, thoracic and mediastinal disorders Epistaxis 0.3
Eye disorders Eye infection 0.3
Gastrointestinal disorders Gastrointestinal pain 0.3
Infections and infestations Herpes dermatitis 0.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.3
Infections and infestations Pneumonia 0.3
Immune system disorders Urticaria 0.3
Infections and infestations Varicella 0.3
Infections and infestations Viral infection 0.3
Infections and infestations Viral upper respiratory tract infection 0.3
Gastrointestinal disorders Abdominal pain 0.299
Skin and subcutaneous tissue disorders Acne 0.299
Musculoskeletal and connective tissue disorders Arthralgia 0.299
Immune system disorders Asthma 0.299
Musculoskeletal and connective tissue disorders Back pain 0.299
Musculoskeletal and connective tissue disorders Bone disorder 0.299
Eye disorders Conjunctivitis 0.299
Gastrointestinal disorders Diarrhoea 0.299
Ear and labyrinth disorders Ear pain 0.299
Respiratory, thoracic and mediastinal disorders Epistaxis 0.299
Gastrointestinal disorders Gastrointestinal pain 0.299
Infections and infestations Herpes dermatitis 0.299
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.299
Infections and infestations Nasopharyngitis 0.299
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 0.299
Respiratory, thoracic and mediastinal disorders Sinus congestion 0.299
Gastrointestinal disorders Toothache 0.299
Immune system disorders Urticaria 0.299
Infections and infestations Viral infection 0.299
Respiratory, thoracic and mediastinal disorders Wheezing 0.299

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
21.86
Skin and subcutaneous tissue disorders
21.25
Injury, poisoning and procedural complications
18.85
Eye disorders
8.95
Nervous system disorders
6.12
Respiratory, thoracic and mediastinal disorders
4.06
Gastrointestinal disorders
3.17
Immune system disorders
2.89

Cross References

Resources Reference
CAS NUMBER 137071-32-0
ChEBI 135888
ChEMBL CHEMBL1200686
DrugBank DB00337
DrugCentral 2168
FDA SRS 7KYV510875
Guide to Pharmacology 6783
PubChem 6509979
SureChEMBL SCHEMBL438880
ZINC ZINC000085536990
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