Trade Names: | |
Synonyms: | |
Status: | Approved (1966) |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
ATC: | L01AX02 |
UNII: | 6Q99RDT97R |
InChI Key | NJBFOOCLYDNZJN-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C10H16Br2N2O2 |
Molecular Weight | 356.06 |
AlogP | 1.23 |
Hydrogen Bond Acceptor | 2.0 |
Hydrogen Bond Donor | 0.0 |
Number of Rotational Bond | 4.0 |
Polar Surface Area | 40.62 |
Molecular species | NEUTRAL |
Aromatic Rings | 0.0 |
Heavy Atoms | 16.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | DNA inhibitor | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 63 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Polycythemia Vera | 3 | D011087 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 54-91-1 |
ChEBI | 8242 |
ChEMBL | CHEMBL1585 |
DrugBank | DB00236 |
DrugCentral | 2192 |
EPA CompTox | DTXSID7023485 |
FDA SRS | 6Q99RDT97R |
Human Metabolome Database | HMDB0014381 |
Guide to Pharmacology | 7271 |
KEGG | C07362 |
PharmGKB | PA164747673 |
PubChem | 4842 |
SureChEMBL | SCHEMBL4889 |
ZINC | ZINC000001530753 |