Trade Names: | |
Synonyms: | |
Status: | Approved (1991) |
Entry Type: | Small molecule |
Molecule Category: | Salt |
UNII: | 3M8608UQ61 |
Parent Compound: | PRAVASTATIN |
InChI Key | VWBQYTRBTXKKOG-IYNICTALSA-M |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H35NaO7 |
Molecular Weight | 446.52 |
AlogP | 2.44 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 10.0 |
Polar Surface Area | 124.29 |
Molecular species | ACID |
Aromatic Rings | 0.0 |
Heavy Atoms | 30.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | HMG-CoA reductase inhibitor | DailyMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Oxidoreductase
|
- | 4-40 | - | - | 28-48 | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 100 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Ischemic Stroke | 3 | D000083242 | ClinicalTrials |
Diabetes Mellitus, Type 1 | 3 | D003922 | ClinicalTrials |
Hyperlipidemia, Familial Combined | 3 | D006950 | ClinicalTrials |
Lipodystrophy | 3 | D008060 | ClinicalTrials |
Liver Neoplasms | 3 | D008113 | ClinicalTrials |
Lung Neoplasms | 3 | D008175 | ClinicalTrials |
HIV Infections | 2 | D015658 | ClinicalTrials |
HIV Infections | 2 | D015658 | ClinicalTrials |
Leukemia | 2 | D007938 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 8361 |
ChEMBL | CHEMBL690 |
EPA CompTox | DTXSID6047525 |
FDA SRS | 3M8608UQ61 |
KEGG | D00893 |
PubChem | 16759173 |
SureChEMBL | SCHEMBL3013 |
ZINC | ZINC03798763 |