Trade Names: | |
Synonyms: | |
Status: | Approved (1955) |
Entry Type: | Small molecule |
Molecule Category: | Salt Prodrug |
UNII: | 8B2807733D |
Parent Compound: | PREDNISOLONE |
InChI Key | LRJOMUJRLNCICJ-JZYPGELDSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H30O6 |
Molecular Weight | 402.49 |
AlogP | 2.13 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 3.0 |
Polar Surface Area | 100.9 |
Molecular species | NEUTRAL |
Aromatic Rings | 0.0 |
Heavy Atoms | 29.0 |
Action | Mechanism of Action | Reference |
---|---|---|
AGONIST | Glucocorticoid receptor agonist | FDA |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 107 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Conjunctivitis, Allergic | 4 | D003233 | ClinicalTrials |
Uveitis | 3 | D014605 | ClinicalTrials |
Sciatica | 3 | D012585 | ClinicalTrials |
Uveitis, Anterior | 3 | D014606 | ClinicalTrials |
Cataract | 3 | D002386 | ClinicalTrials |
Eye Infections | 3 | D015817 | ClinicalTrials |
Low Back Pain | 3 | D017116 | ClinicalTrials |
Macular Edema | 2 | D008269 | ClinicalTrials |
Retinal Vein Occlusion | 2 | D012170 | ClinicalTrials |
Iritis | 2 | D007500 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 52-21-1 |
ChEBI | 8380 |
ChEMBL | CHEMBL1152 |
DrugBank | DB15566 |
DrugCentral | 2247 |
EPA CompTox | DTXSID3023502 |
FDA SRS | 8B2807733D |
KEGG | C08180 |
PubChem | 5834 |
SureChEMBL | SCHEMBL7999 |
ZINC | ZINC000003875348 |