PYRIDOSTIGMINE BROMIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1955)
Entry Type: Small molecule
Molecule Category: Salt
UNII: KVI301NA53
Parent Compound: PYRIDOSTIGMINE

Structure
InChI Key VNYBTNPBYXSMOO-UHFFFAOYSA-M
Smile CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-]
InChI
InChI=1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H13BrN2O2
Molecular Weight 261.12
AlogP 0.57
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 1.0
Polar Surface Area 33.42
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 13.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Acetylcholinesterase inhibitor DailyMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 350-40000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 112

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Heart Failure 2 D006333 ClinicalTrials
Parkinson Disease 2 D010300 ClinicalTrials
Hypotension 2 D007022 ClinicalTrials
Hypotension, Orthostatic 2 D007024 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Glycogen Storage Disease Type II 0 D006009 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
14.17
Nervous system disorders
13.39
Gastrointestinal disorders
9.71
Musculoskeletal and connective tissue disorders
8.07
Injury, poisoning and procedural complications
7.29
Respiratory, thoracic and mediastinal disorders
6.47
Immune system disorders
5.08
Cardiac disorders
4.34
Product issues
3.93
Eye disorders
3.77
Skin and subcutaneous tissue disorders
3.69
Psychiatric disorders
3.28
Vascular disorders
2.58
Infections and infestations
2.46

Cross References

Resources Reference
ChEBI 8666
ChEMBL CHEMBL812
EPA CompTox DTXSID9023540
FDA SRS KVI301NA53
KEGG C07410
PubChem 7550
SureChEMBL SCHEMBL41147
ZINC ZINC00002009
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