Structure

InChI Key RUOKEQAAGRXIBM-GFCCVEGCSA-N
Smile C#CCN[C@@H]1CCc2ccccc21
InChI
InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H13N
Molecular Weight 171.24
AlogP 1.9
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 12.03
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 13.0

Pharmacology

Primary Target
Monoamine oxidase B

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Supranuclear Palsy, Progressive 3 D013494 ClinicalTrials
Amyotrophic Lateral Sclerosis 2 D000690 ClinicalTrials
Restless Legs Syndrome 2 D012148 ClinicalTrials
Alzheimer Disease 2 D000544 ClinicalTrials

Related Entries

Salt

Side Effects from Label

Side effects Relative Frequency (%) Labels
Nervous system disorders Dyskinesia 18.0
Nervous system disorders Headache 14.0
Nervous system disorders Headache
Injury, poisoning and procedural complications Injury 12.0
Gastrointestinal disorders Nausea 12.0
Nervous system disorders Headache 11.0
Nervous system disorders Dyskinesia
Nervous system disorders Headache
Gastrointestinal disorders Nausea 10.0
Gastrointestinal disorders Constipation 9.0
Nervous system disorders Orthostatic hypotension 9.0
Investigations Weight decreased 9.0
Musculoskeletal and connective tissue disorders Arthralgia 8.0
Nervous system disorders Headache 8.0
Injury, poisoning and procedural complications Injury 8.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 8.0
Gastrointestinal disorders Nausea
Musculoskeletal and connective tissue disorders Arthralgia 7.0
Gastrointestinal disorders Diarrhoea 7.0
Cardiac disorders Dizziness 7.0
Gastrointestinal disorders Dyspepsia 7.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 7.0
Cardiac disorders Oedema peripheral 7.0
Gastrointestinal disorders Vomiting 7.0
Musculoskeletal and connective tissue disorders Arthralgia 6.0
Nervous system disorders Ataxia 6.0
Skin and subcutaneous tissue disorders Dermatitis 6.0
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth 6.0
Nervous system disorders Headache 6.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.0
Gastrointestinal disorders Nausea 6.0
Nervous system disorders Orthostatic hypotension 6.0
Skin and subcutaneous tissue disorders Rash 6.0
Nervous system disorders Somnolence 6.0
Gastrointestinal disorders Abdominal pain 5.0
Musculoskeletal and connective tissue disorders Arthralgia 5.0
Gastrointestinal disorders Constipation
General disorders and administration site conditions Decreased appetite 5.0
Psychiatric disorders Depression 5.0
Gastrointestinal disorders Diarrhoea 5.0
Gastrointestinal disorders Dyspepsia 5.0
Cardiac disorders Dyspnoea 5.0
Blood and lymphatic system disorders Ecchymosis 5.0
Gastrointestinal disorders Gastrointestinal pain 5.0
Psychiatric disorders Hallucination 5.0
Infections and infestations Influenza 5.0
Injury, poisoning and procedural complications Injury
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.0
Nervous system disorders Paraesthesia 5.0
Nervous system disorders Abnormal dreams 4.0
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Back pain 4.0
Gastrointestinal disorders Constipation 4.0
Respiratory, thoracic and mediastinal disorders Cough 4.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia 4.0
Psychiatric disorders Hallucination 4.0
Nervous system disorders Headache
Nervous system disorders Insomnia 4.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Gastrointestinal disorders Nausea
Cardiac disorders Oedema peripheral
Nervous system disorders Somnolence
Nervous system disorders Somnolence 4.0
Infections and infestations Upper respiratory tract infection 4.0
Gastrointestinal disorders Vomiting 4.0
Nervous system disorders Ataxia 3.0
Musculoskeletal and connective tissue disorders Back pain
Investigations Body temperature increased 3.0
Eye disorders Conjunctivitis 3.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis 3.0
Gastrointestinal disorders Dry mouth
Cardiac disorders Dyspnoea 3.0
Blood and lymphatic system disorders Ecchymosis
Gastrointestinal disorders Gastroenteritis 3.0
Psychiatric disorders Hallucination
General disorders and administration site conditions Hyperhidrosis 3.0
Infections and infestations Infection 3.0
Musculoskeletal and connective tissue disorders Neck pain 3.0
Nervous system disorders Orthostatic hypotension
Nervous system disorders Orthostatic hypotension 3.0
Nervous system disorders Paraesthesia
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash 3.0
Infections and infestations Rhinitis 3.0
Musculoskeletal and connective tissue disorders Tenosynovitis 3.0
Investigations Weight decreased
Gastrointestinal disorders Abdominal pain 2.0
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Arthritis 2.0
General disorders and administration site conditions Decreased appetite 2.0
Psychiatric disorders Depression
General disorders and administration site conditions Discomfort 2.0
Gastrointestinal disorders Dry mouth 2.0
Cardiac disorders Dyspnoea
Blood and lymphatic system disorders Ecchymosis 2.0
General disorders and administration site conditions Feeling abnormal 2.0
Gastrointestinal disorders Gastrointestinal pain 2.0
Gastrointestinal disorders Gingivitis 2.0
Investigations Haemoglobin 2.0
Vascular disorders Haemorrhage 2.0
General disorders and administration site conditions Hernia 2.0
General disorders and administration site conditions Hyperhidrosis 2.0
General disorders and administration site conditions Ill-defined disorder 2.0
Infections and infestations Infection
Infections and infestations Infection 2.0
General disorders and administration site conditions Malaise 2.0
Nervous system disorders Muscular weakness 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Neck pain 2.0
Nervous system disorders Paraesthesia 2.0
Infections and infestations Upper respiratory tract infection
Ear and labyrinth disorders Vertigo 2.0
Investigations Weight decreased 2.0
Gastrointestinal disorders Abdominal pain
Nervous system disorders Abnormal dreams
Nervous system disorders Abnormal dreams 1.0
Musculoskeletal and connective tissue disorders Arthritis
Nervous system disorders Ataxia
Investigations Body temperature increased
Eye disorders Conjunctivitis
Respiratory, thoracic and mediastinal disorders Cough
General disorders and administration site conditions Decreased appetite
Gastrointestinal disorders Gastroenteritis
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Gingivitis
Gastrointestinal disorders Gingivitis 1.0
Investigations Haemoglobin
Investigations Haemoglobin 1.0
Vascular disorders Haemorrhage
Vascular disorders Haemorrhage 1.0
General disorders and administration site conditions Hernia
General disorders and administration site conditions Hernia 1.0
General disorders and administration site conditions Hyperhidrosis
Infections and infestations Influenza
Nervous system disorders Insomnia
Nervous system disorders Muscular weakness
Musculoskeletal and connective tissue disorders Neck pain
Musculoskeletal and connective tissue disorders Neck pain 1.0
Nervous system disorders Orthostatic hypotension
Nervous system disorders Paraesthesia
Infections and infestations Rhinitis
Musculoskeletal and connective tissue disorders Tenosynovitis 1.0
Ear and labyrinth disorders Vertigo
Gastrointestinal disorders Vomiting

Cross References

Resources Reference
CAS NUMBER 136236-51-6
ChEBI 63620
ChEMBL CHEMBL887
DrugBank DB01367
DrugCentral 3521
EPA CompTox DTXSID3041112
FDA SRS 003N66TS6T
Human Metabolome Database HMDB0015454
Guide to Pharmacology 6641
PDB RAU
PharmGKB PA164764584
PubChem 3052776
SureChEMBL SCHEMBL74699
ZINC ZINC000019875504