RIBAVIRIN

Search structure
Trade Names:
Synonyms:
Status: Approved (1985)
Entry Type: Small molecule
Molecule Category: Parent
ATC: J05AP01
UNII: 49717AWG6K

Structure
InChI Key IWUCXVSUMQZMFG-AFCXAGJDSA-N
Smile NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1
InChI
InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H12N4O5
Molecular Weight 244.21
AlogP -3.01
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 3.0
Polar Surface Area 143.72
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor PubMed Wikipedia
Primary Target
inosine monophosphate dehydrogenase 1
inosine monophosphate dehydrogenase 2
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
23800 - - - -
Enzyme Isomerase
- 65880 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase GSK family
- - - - 33
Enzyme Transferase
20800 - - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Adenosine receptor
- - - 4430 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 112
Unclassified protein
24000 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 3 D003866 ClinicalTrials
HIV Infections 3 D015658 ClinicalTrials
Infections 3 D007239 ClinicalTrials
Hepatitis B, Chronic 3 D019694 ClinicalTrials
Hepatitis 3 D006505 ClinicalTrials
Hepatitis C 3 D006526 ClinicalTrials
Hepatitis B, Chronic 3 D019694 ClinicalTrials
Respiratory Syncytial Virus Infections 3 D018357 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Lassa Fever 2 D007835 ClinicalTrials
Hemorrhagic Fever with Renal Syndrome 2 D006480 ClinicalTrials
Hepatitis D 2 D003699 ClinicalTrials
Encephalitis, Japanese 2 D004672 ClinicalTrials
Thrombocytopenia 2 D013921 ClinicalTrials
Influenza, Human 2 D007251 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

MCS

Side Effects from Label

Side effects Relative Frequency (%) Labels
General disorders and administration site conditions Influenza like illness 91.0
General disorders and administration site conditions Influenza like illness
Investigations Body temperature increased 80.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Asthenia 70.0
General disorders and administration site conditions Fatigue 70.0
Nervous system disorders Headache 69.0
General disorders and administration site conditions Asthenia 68.0
General disorders and administration site conditions Fatigue 68.0
Nervous system disorders Headache
General disorders and administration site conditions Asthenia 67.0
General disorders and administration site conditions Fatigue 67.0
Nervous system disorders Headache
General disorders and administration site conditions Asthenia 66.0
General disorders and administration site conditions Fatigue 66.0
Nervous system disorders Headache 66.0
General disorders and administration site conditions Asthenia 65.0
General disorders and administration site conditions Fatigue 65.0
General disorders and administration site conditions Asthenia 64.0
General disorders and administration site conditions Fatigue 64.0
Nervous system disorders Headache 64.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 64.0
Musculoskeletal and connective tissue disorders Myalgia 64.0
General disorders and administration site conditions Asthenia 63.0
General disorders and administration site conditions Fatigue 63.0
Nervous system disorders Headache
Nervous system disorders Headache 63.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
Nervous system disorders Headache 62.0
General disorders and administration site conditions Asthenia 61.0
Investigations Body temperature increased 61.0
General disorders and administration site conditions Fatigue 61.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 61.0
Musculoskeletal and connective tissue disorders Myalgia 61.0
General disorders and administration site conditions Asthenia 60.0
General disorders and administration site conditions Fatigue 60.0
Infections and infestations Upper respiratory tract infection 60.0
General disorders and administration site conditions Asthenia 59.0
General disorders and administration site conditions Fatigue 59.0
General disorders and administration site conditions Injection site reaction 59.0
General disorders and administration site conditions Asthenia 58.0
General disorders and administration site conditions Fatigue 58.0
Nervous system disorders Headache 58.0
General disorders and administration site conditions Injection site reaction 58.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Nervous system disorders Headache 57.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Gastrointestinal disorders Gastrointestinal disorder 56.0
General disorders and administration site conditions Injection site inflammation 56.0
Investigations Body temperature increased 55.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 55.0
Musculoskeletal and connective tissue disorders Myalgia 55.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Decreased appetite 51.0
Nervous system disorders Headache 51.0
Nervous system disorders Headache 50.0
General disorders and administration site conditions Injection site inflammation 50.0
Gastrointestinal disorders Gastrointestinal disorder 49.0
Nervous system disorders Headache 49.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 49.0
Musculoskeletal and connective tissue disorders Myalgia 49.0
General disorders and administration site conditions Chills 48.0
Nervous system disorders Headache 47.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 47.0
Musculoskeletal and connective tissue disorders Myalgia 47.0
Gastrointestinal disorders Nausea 47.0
Skin and subcutaneous tissue disorders Skin disorder 47.0
Investigations Body temperature increased 46.0
Gastrointestinal disorders Nausea 46.0
Investigations Body temperature increased 45.0
General disorders and administration site conditions Injection site reaction 45.0
General disorders and administration site conditions Chills 44.0
Gastrointestinal disorders Gastrointestinal disorder
General disorders and administration site conditions Injection site reaction 44.0
Investigations Body temperature increased 43.0
General disorders and administration site conditions Chills 43.0
Gastrointestinal disorders Nausea 43.0
General disorders and administration site conditions Chills 42.0
General disorders and administration site conditions Injection site reaction
Gastrointestinal disorders Vomiting 42.0
Investigations Body temperature increased 41.0
General disorders and administration site conditions Chills 41.0
Nervous system disorders Headache 41.0
General disorders and administration site conditions Hyperhidrosis 41.0
Nervous system disorders Insomnia 41.0
Investigations Body temperature increased
General disorders and administration site conditions Chills 40.0
General disorders and administration site conditions Hyperhidrosis 40.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 40.0
Musculoskeletal and connective tissue disorders Myalgia 40.0
Gastrointestinal disorders Nausea 40.0
Blood and lymphatic system disorders Neutropenia 40.0
General disorders and administration site conditions Chills
General disorders and administration site conditions Chills 39.0
Nervous system disorders Headache
Nervous system disorders Insomnia 39.0
Psychiatric disorders Anxiety 38.0
Nervous system disorders Insomnia 38.0
General disorders and administration site conditions Irritability 38.0
Gastrointestinal disorders Nausea 38.0
Psychiatric disorders Nervousness 38.0
Psychiatric disorders Tension 38.0
Investigations Body temperature increased 37.0
General disorders and administration site conditions Chills
General disorders and administration site conditions Chills 37.0
Psychiatric disorders Depression
Nervous system disorders Insomnia 37.0
Skin and subcutaneous tissue disorders Alopecia 36.0
Musculoskeletal and connective tissue disorders Arthralgia
Investigations Body temperature increased
General disorders and administration site conditions Chills 36.0
Psychiatric disorders Depression 36.0
Gastrointestinal disorders Diarrhoea 36.0
General disorders and administration site conditions Injection site reaction 36.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Blood and lymphatic system disorders Anaemia 35.0
Investigations Body temperature increased
Investigations Body temperature increased 35.0
General disorders and administration site conditions Injection site reaction 35.0
General disorders and administration site conditions Irritability 35.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain 35.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 35.0
Blood and lymphatic system disorders Anaemia 34.0
Skin and subcutaneous tissue disorders Dermatitis 34.0
General disorders and administration site conditions Flushing 34.0
General disorders and administration site conditions Injection site reaction 34.0
General disorders and administration site conditions Irritability 34.0
Gastrointestinal disorders Nausea 34.0
Skin and subcutaneous tissue disorders Rash 34.0
Skin and subcutaneous tissue disorders Alopecia 33.0
Musculoskeletal and connective tissue disorders Arthralgia 33.0
Investigations Body temperature increased 33.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 33.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 33.0
Blood and lymphatic system disorders Neutropenia 33.0
Skin and subcutaneous tissue disorders Alopecia 32.0
Musculoskeletal and connective tissue disorders Arthralgia 32.0
Investigations Body temperature increased 32.0
General disorders and administration site conditions Chills
Eye disorders Conjunctivitis 32.0
General disorders and administration site conditions Decreased appetite 32.0
Psychiatric disorders Depression 32.0
Gastrointestinal disorders Diarrhoea 32.0
General disorders and administration site conditions Irritability 32.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 32.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain
Musculoskeletal and connective tissue disorders Myalgia 32.0
Musculoskeletal and connective tissue disorders Arthralgia 31.0
General disorders and administration site conditions Flushing 31.0
General disorders and administration site conditions Influenza like illness 31.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 31.0
Gastrointestinal disorders Nausea 31.0
Blood and lymphatic system disorders Neutropenia 31.0
Blood and lymphatic system disorders Anaemia 30.0
Musculoskeletal and connective tissue disorders Arthralgia 30.0
General disorders and administration site conditions Asthenia 30.0
Psychiatric disorders Depression 30.0
General disorders and administration site conditions Fatigue 30.0
Nervous system disorders Insomnia
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 30.0
Skin and subcutaneous tissue disorders Alopecia 29.0
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Arthralgia 29.0
General disorders and administration site conditions Decreased appetite 29.0
Psychiatric disorders Depression 29.0
Skin and subcutaneous tissue disorders Dermatitis 29.0
General disorders and administration site conditions Injection site erythema 29.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 29.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain
Gastrointestinal disorders Nausea 29.0
Skin and subcutaneous tissue disorders Rash 29.0
Gastrointestinal disorders Vomiting 29.0
Investigations Weight decreased 29.0
Skin and subcutaneous tissue disorders Alopecia
Skin and subcutaneous tissue disorders Alopecia 28.0
Psychiatric disorders Depression 28.0
Skin and subcutaneous tissue disorders Dermatitis 28.0
General disorders and administration site conditions Injection site reaction 28.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain
Musculoskeletal and connective tissue disorders Musculoskeletal pain 28.0
Skin and subcutaneous tissue disorders Rash 28.0
Gastrointestinal disorders Vomiting 28.0
Investigations Weight decreased 28.0
Skin and subcutaneous tissue disorders Alopecia
Skin and subcutaneous tissue disorders Alopecia 27.0
Musculoskeletal and connective tissue disorders Arthralgia
General disorders and administration site conditions Decreased appetite 27.0
General disorders and administration site conditions Influenza like illness 27.0
General disorders and administration site conditions Injection site inflammation 27.0
Nervous system disorders Insomnia
General disorders and administration site conditions Irritability
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 27.0
Musculoskeletal and connective tissue disorders Myalgia 27.0
Blood and lymphatic system disorders Neutropenia 27.0
Skin and subcutaneous tissue disorders Pruritus 27.0
Gastrointestinal disorders Vomiting 27.0
Skin and subcutaneous tissue disorders Alopecia
Musculoskeletal and connective tissue disorders Arthralgia 26.0
General disorders and administration site conditions Decreased appetite 26.0
Cardiac disorders Dizziness 26.0
Nervous system disorders Insomnia 26.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 26.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain
Musculoskeletal and connective tissue disorders Myalgia 26.0
Blood and lymphatic system disorders Neutropenia 26.0
General disorders and administration site conditions Asthenia 25.0
General disorders and administration site conditions Chills 25.0
General disorders and administration site conditions Decreased appetite 25.0
Psychiatric disorders Depression
Psychiatric disorders Depression 25.0
Skin and subcutaneous tissue disorders Dermatitis 25.0
Cardiac disorders Dyspnoea 25.0
General disorders and administration site conditions Fatigue 25.0
General disorders and administration site conditions Injection site inflammation 25.0
Nervous system disorders Insomnia
General disorders and administration site conditions Irritability 25.0
Gastrointestinal disorders Nausea 25.0
Skin and subcutaneous tissue disorders Pruritus 25.0
Skin and subcutaneous tissue disorders Rash 25.0
Gastrointestinal disorders Vomiting 25.0
Gastrointestinal disorders Abdominal pain 24.0
General disorders and administration site conditions Decreased appetite 24.0
Cardiac disorders Dizziness 24.0
Gastrointestinal disorders Dyspepsia 24.0
Gastrointestinal disorders Gastrointestinal pain 24.0
General disorders and administration site conditions Influenza like illness 24.0
General disorders and administration site conditions Irritability 24.0
Gastrointestinal disorders Abdominal pain 23.0
Skin and subcutaneous tissue disorders Alopecia 23.0
Musculoskeletal and connective tissue disorders Arthralgia 23.0
General disorders and administration site conditions Chills 23.0
Psychiatric disorders Depression 23.0
Cardiac disorders Dizziness 23.0
Skin and subcutaneous tissue disorders Dry skin 23.0
Gastrointestinal disorders Dyspepsia 23.0
Cardiac disorders Dyspnoea 23.0
Gastrointestinal disorders Gastrointestinal pain 23.0
General disorders and administration site conditions Influenza like illness 23.0
General disorders and administration site conditions Injection site reaction 23.0
General disorders and administration site conditions Irritability 23.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 23.0
Blood and lymphatic system disorders Anaemia 22.0
Musculoskeletal and connective tissue disorders Arthralgia 22.0
General disorders and administration site conditions Decreased appetite 22.0
Skin and subcutaneous tissue disorders Dermatitis 22.0
Gastrointestinal disorders Diarrhoea 22.0
Cardiac disorders Dyspnoea 22.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 22.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain 22.0
Musculoskeletal and connective tissue disorders Myalgia 22.0
Skin and subcutaneous tissue disorders Rash 22.0
Gastrointestinal disorders Abdominal pain 21.0
Musculoskeletal and connective tissue disorders Arthralgia 21.0
General disorders and administration site conditions Asthenia 21.0
Investigations Body temperature increased 21.0
General disorders and administration site conditions Chills 21.0
General disorders and administration site conditions Decreased appetite 21.0
Skin and subcutaneous tissue disorders Dermatitis 21.0
Nervous system disorders Disturbance in attention 21.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness 21.0
Skin and subcutaneous tissue disorders Dry skin 21.0
Cardiac disorders Dyspnoea 21.0
General disorders and administration site conditions Fatigue 21.0
Gastrointestinal disorders Gastrointestinal pain 21.0
Social circumstances Mental disability 21.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 21.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain 21.0
Skin and subcutaneous tissue disorders Pruritus 21.0
Skin and subcutaneous tissue disorders Rash 21.0
Skin and subcutaneous tissue disorders Alopecia 20.0
General disorders and administration site conditions Asthenia
Psychiatric disorders Depression 20.0
Skin and subcutaneous tissue disorders Dermatitis 20.0
Cardiac disorders Dizziness 20.0
Cardiac disorders Dyspnoea 20.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Influenza like illness
General disorders and administration site conditions Irritability
Musculoskeletal and connective tissue disorders Musculoskeletal pain 20.0
Blood and lymphatic system disorders Neutropenia 20.0
Skin and subcutaneous tissue disorders Rash 20.0
Investigations Weight decreased 20.0
General disorders and administration site conditions Decreased appetite
Psychiatric disorders Depression 19.0
Gastrointestinal disorders Diarrhoea 19.0
Cardiac disorders Dizziness
Cardiac disorders Dyspnoea 19.0
General disorders and administration site conditions Injection site reaction 19.0
General disorders and administration site conditions Irritability
Blood and lymphatic system disorders Neutropenia 19.0
Skin and subcutaneous tissue disorders Pruritus 19.0
Investigations Weight decreased 19.0
General disorders and administration site conditions Asthenia 18.0
Cardiac disorders Dizziness 18.0
Cardiac disorders Dyspnoea 18.0
General disorders and administration site conditions Influenza like illness
General disorders and administration site conditions Influenza like illness 18.0
General disorders and administration site conditions Injection site inflammation 18.0
Gastrointestinal disorders Nausea 18.0
Blood and lymphatic system disorders Neutropenia 18.0
Skin and subcutaneous tissue disorders Pruritus 18.0
Skin and subcutaneous tissue disorders Alopecia 17.0
Blood and lymphatic system disorders Anaemia 17.0
Musculoskeletal and connective tissue disorders Arthralgia 17.0
General disorders and administration site conditions Asthenia 17.0
Respiratory, thoracic and mediastinal disorders Cough 17.0
Skin and subcutaneous tissue disorders Dermatitis 17.0
Gastrointestinal disorders Diarrhoea 17.0
Nervous system disorders Disturbance in attention 17.0
Cardiac disorders Dizziness 17.0
Skin and subcutaneous tissue disorders Dry skin 17.0
Cardiac disorders Dyspnoea 17.0
General disorders and administration site conditions Fatigue 17.0
General disorders and administration site conditions Injection site inflammation 17.0
Social circumstances Mental disability 17.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 17.0
Musculoskeletal and connective tissue disorders Myalgia 17.0
Skin and subcutaneous tissue disorders Rash 17.0
Blood and lymphatic system disorders Anaemia 16.3
Psychiatric disorders Affect lability 16.0
Respiratory, thoracic and mediastinal disorders Cough 16.0
General disorders and administration site conditions Decreased appetite
Gastrointestinal disorders Diarrhoea 16.0
Nervous system disorders Disturbance in attention 16.0
Cardiac disorders Dizziness 16.0
Gastrointestinal disorders Dyspepsia 16.0
General disorders and administration site conditions Influenza like illness 16.0
General disorders and administration site conditions Injection site reaction 16.0
Social circumstances Mental disability 16.0
Psychiatric disorders Mood swings 16.0
Investigations Weight decreased 16.0
Musculoskeletal and connective tissue disorders Arthralgia 15.0
General disorders and administration site conditions Asthenia 15.0
Respiratory, thoracic and mediastinal disorders Cough 15.0
Skin and subcutaneous tissue disorders Dermatitis 15.0
Gastrointestinal disorders Diarrhoea 15.0
Cardiac disorders Dizziness
General disorders and administration site conditions Influenza like illness 15.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 15.0
Skin and subcutaneous tissue disorders Pruritus 15.0
Skin and subcutaneous tissue disorders Rash 15.0
Blood and lymphatic system disorders Anaemia 14.0
Psychiatric disorders Anxiety 14.0
Infections and infestations Candida infection 14.0
Respiratory, thoracic and mediastinal disorders Cough 14.0
General disorders and administration site conditions Decreased appetite
Psychiatric disorders Depression
Gastrointestinal disorders Diarrhoea 14.0
Nervous system disorders Disturbance in attention
Nervous system disorders Disturbance in attention 14.0
Cardiac disorders Dizziness 14.0
Gastrointestinal disorders Dyspepsia 14.0
Cardiac disorders Dyspnoea 14.0
General disorders and administration site conditions Influenza like illness 14.0
General disorders and administration site conditions Injection site inflammation
General disorders and administration site conditions Injection site inflammation 14.0
Nervous system disorders Insomnia 14.0
General disorders and administration site conditions Irritability
General disorders and administration site conditions Irritability 14.0
Blood and lymphatic system disorders Lymphopenia 14.0
Social circumstances Mental disability
Social circumstances Mental disability 14.0
Blood and lymphatic system disorders Neutropenia 14.0
Gastrointestinal disorders Oral candidiasis 14.0
Infections and infestations Sinusitis
Ear and labyrinth disorders Vertigo 14.0
Gastrointestinal disorders Vomiting 14.0
Gastrointestinal disorders Abdominal pain 13.0
Psychiatric disorders Depression 13.0
Skin and subcutaneous tissue disorders Dermatitis 13.0
Gastrointestinal disorders Diarrhoea 13.0
Nervous system disorders Disturbance in attention 13.0
Cardiac disorders Dizziness 13.0
Skin and subcutaneous tissue disorders Dry skin 13.0
Gastrointestinal disorders Gastrointestinal pain 13.0
Endocrine disorders Hypothyroidism 13.0
General disorders and administration site conditions Influenza like illness
General disorders and administration site conditions Influenza like illness 13.0
General disorders and administration site conditions Injection site inflammation 13.0
Metabolism and nutrition disorders Lipodystrophy acquired 13.0
Social circumstances Mental disability 13.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain 13.0
General disorders and administration site conditions Pain 13.0
Skin and subcutaneous tissue disorders Pruritus 13.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 13.0
Investigations Weight decreased 13.0
Gastrointestinal disorders Abdominal pain upper 12.0
Psychiatric disorders Affect lability 12.0
Blood and lymphatic system disorders Anaemia 12.0
Cardiac disorders Chest pain 12.0
Nervous system disorders Disturbance in attention
Gastrointestinal disorders Dry mouth 12.0
Skin and subcutaneous tissue disorders Dry skin 12.0
Cardiac disorders Dyspnoea
Endocrine disorders Hypothyroidism 12.0
General disorders and administration site conditions Injection site inflammation 12.0
Nervous system disorders Insomnia
Blood and lymphatic system disorders Lymphopenia 12.0
Social circumstances Mental disability
Psychiatric disorders Mood swings 12.0
General disorders and administration site conditions Pain 12.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Pruritus 12.0
Infections and infestations Sinusitis 12.0
Gastrointestinal disorders Vomiting 12.0
Psychiatric disorders Affect lability 11.0
Blood and lymphatic system disorders Anaemia 11.0
Psychiatric disorders Anxiety 11.0
Respiratory, thoracic and mediastinal disorders Cough 11.0
General disorders and administration site conditions Decreased appetite 11.0
Gastrointestinal disorders Diarrhoea 11.0
Nervous system disorders Disturbance in attention 11.0
Gastrointestinal disorders Dry mouth 11.0
Skin and subcutaneous tissue disorders Dry skin 11.0
General disorders and administration site conditions Hyperhidrosis 11.0
Social circumstances Mental disability 11.0
Psychiatric disorders Mood swings 11.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain 11.0
Skin and subcutaneous tissue disorders Pruritus 11.0
Gastrointestinal disorders Vomiting 11.0
Gastrointestinal disorders Abdominal pain 10.0
Psychiatric disorders Affect lability 10.0
Psychiatric disorders Anxiety 10.0
General disorders and administration site conditions Asthenia 10.0
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Diarrhoea 10.0
Nervous system disorders Disturbance in attention 10.0
Cardiac disorders Dyspnoea
Gastrointestinal disorders Gastrointestinal pain 10.0
General disorders and administration site conditions Injection site inflammation
General disorders and administration site conditions Irritability 10.0
Blood and lymphatic system disorders Leukopenia 10.0
Social circumstances Mental disability 10.0
Psychiatric disorders Mood swings 10.0
General disorders and administration site conditions Pain 10.0
Skin and subcutaneous tissue disorders Rash
Infections and infestations Sinusitis 10.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 10.0
Investigations Weight decreased 10.0
Blood and lymphatic system disorders Anaemia 9.79
Gastrointestinal disorders Abdominal pain 9.0
Blood and lymphatic system disorders Anaemia 9.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 9.0
Blood and lymphatic system disorders Blood disorder 9.0
Cardiac disorders Chest pain 9.0
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia 9.0
Cardiac disorders Dyspnoea
Investigations Gamma-glutamyltransferase increased 9.0
Gastrointestinal disorders Gastrointestinal pain 9.0
General disorders and administration site conditions Hyperhidrosis 9.0
General disorders and administration site conditions Injection site reaction
Nervous system disorders Insomnia 9.0
Blood and lymphatic system disorders Leukopenia 9.0
Psychiatric disorders Mood swings 9.0
General disorders and administration site conditions Pain 9.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Rash
Infections and infestations Sinusitis 9.0
Gastrointestinal disorders Vomiting 9.0
Gastrointestinal disorders Abdominal pain 8.0
Psychiatric disorders Affect lability
Investigations CD4 lymphocytes decreased 8.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain 8.0
General disorders and administration site conditions Decreased appetite 8.0
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Dry mouth 8.0
Gastrointestinal disorders Dysgeusia 8.0
Gastrointestinal disorders Dyspepsia 8.0
Gastrointestinal disorders Gastrointestinal pain 8.0
Nervous system disorders Headache 8.0
General disorders and administration site conditions Injection site inflammation
General disorders and administration site conditions Injection site reaction 8.0
Psychiatric disorders Mood swings
Psychiatric disorders Nervousness 8.0
Blood and lymphatic system disorders Neutropenia 8.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Rash
Psychiatric disorders Tension 8.0
Blood and lymphatic system disorders Thrombocytopenia 8.0
Gastrointestinal disorders Vomiting
Blood and lymphatic system disorders Anaemia 7.69
Psychiatric disorders Affect lability 7.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain 7.0
Respiratory, thoracic and mediastinal disorders Cough 7.0
Gastrointestinal disorders Dry mouth 7.0
Gastrointestinal disorders Dysgeusia 7.0
Cardiac disorders Dyspnoea exertional 7.0
General disorders and administration site conditions Hyperhidrosis 7.0
General disorders and administration site conditions Injection site reaction 7.0
Blood and lymphatic system disorders Leukopenia 7.0
Psychiatric disorders Mood swings 7.0
Infections and infestations Sinusitis
Investigations Weight decreased 7.0
Gastrointestinal disorders Abdominal pain upper 6.0
Psychiatric disorders Affect lability
Investigations Amylase increased 6.0
Blood and lymphatic system disorders Anaemia 6.0
Cardiac disorders Chest pain 6.0
General disorders and administration site conditions Chills 6.0
General disorders and administration site conditions Discomfort 6.0
Gastrointestinal disorders Dysgeusia 6.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia 6.0
General disorders and administration site conditions Feeling abnormal 6.0
Hepatobiliary disorders Hepatitis 6.0
General disorders and administration site conditions Ill-defined disorder 6.0
General disorders and administration site conditions Injection site inflammation 6.0
Blood and lymphatic system disorders Leukopenia 6.0
Investigations Lipase increased 6.0
General disorders and administration site conditions Malaise 6.0
Psychiatric disorders Mood swings
Psychiatric disorders Mood swings 6.0
Gastrointestinal disorders Nausea 6.0
Musculoskeletal and connective tissue disorders Pain in extremity 6.0
Investigations Weight decreased 6.0
Blood and lymphatic system disorders Anaemia 5.0
General disorders and administration site conditions Asthenia 5.0
Musculoskeletal and connective tissue disorders Back pain 5.0
Cardiac disorders Chest pain 5.0
Gastrointestinal disorders Constipation 5.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis 5.0
Nervous system disorders Disturbance in attention 5.0
Gastrointestinal disorders Dysgeusia
Gastrointestinal disorders Dyspepsia 5.0
Cardiac disorders Dyspnoea 5.0
Nervous system disorders Headache 5.0
General disorders and administration site conditions Hyperhidrosis 5.0
Metabolism and nutrition disorders Hyperlactacidaemia 5.0
Endocrine disorders Hypothyroidism 5.0
General disorders and administration site conditions Injection site reaction 5.0
Blood and lymphatic system disorders Leukopenia 5.0
Nervous system disorders Memory impairment 5.0
Social circumstances Mental disability 5.0
Gastrointestinal disorders Nausea 5.0
Psychiatric disorders Nervousness 5.0
Nervous system disorders Paraesthesia 5.0
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash 5.0
Infections and infestations Rhinitis 5.0
Psychiatric disorders Tension 5.0
Blood and lymphatic system disorders Thrombocytopenia 5.0
Blood and lymphatic system disorders Thrombocytopenia 4.65
Blood and lymphatic system disorders Thrombocytopenia 4.64
Blood and lymphatic system disorders Anaemia 4.23
General disorders and administration site conditions Asthenia
Blood and lymphatic system disorders Blood disorder 4.0
Investigations Body temperature increased 4.0
Cardiac disorders Chest pain
Psychiatric disorders Depressed mood 4.0
General disorders and administration site conditions Discomfort 4.0
Gastrointestinal disorders Dry mouth 4.0
Gastrointestinal disorders Dysgeusia
Skin and subcutaneous tissue disorders Eczema 4.0
General disorders and administration site conditions Feeling abnormal 4.0
General disorders and administration site conditions Flushing 4.0
Hepatobiliary disorders Hepatomegaly 4.0
Endocrine disorders Hypothyroidism 4.0
General disorders and administration site conditions Ill-defined disorder 4.0
Blood and lymphatic system disorders Leukopenia 4.0
General disorders and administration site conditions Malaise 4.0
Psychiatric disorders Nervousness
Psychiatric disorders Nervousness 4.0
Skin and subcutaneous tissue disorders Pruritus
Psychiatric disorders Tension
Psychiatric disorders Tension 4.0
Blood and lymphatic system disorders Thrombocytopenia 4.0
Blood and lymphatic system disorders Thrombocytopenia 3.85
Psychiatric disorders Aggression 3.0
General disorders and administration site conditions Flushing 3.0
Endocrine disorders Hypothyroidism 3.0
General disorders and administration site conditions Injection site reaction
Psychiatric disorders Nervousness 3.0
Psychiatric disorders Tension 3.0
Psychiatric disorders Anger 2.0
Psychiatric disorders Nervousness
Psychiatric disorders Tension
Blood and lymphatic system disorders Thrombocytopenia 2.0
Eye disorders Vision blurred 2.0
General disorders and administration site conditions Discomfort 1.0
Gastrointestinal disorders Dysgeusia 1.0
Gastrointestinal disorders Dyspepsia 1.0
General disorders and administration site conditions Feeling abnormal 1.0
Nervous system disorders Headache 1.0
General disorders and administration site conditions Ill-defined disorder 1.0
General disorders and administration site conditions Injection site pain 1.0
General disorders and administration site conditions Malaise 1.0
Blood and lymphatic system disorders Neutropenia 1.0
Musculoskeletal and connective tissue disorders Pain in extremity 1.0
Infections and infestations Sinusitis 1.0
Blood and lymphatic system disorders Thrombocytopenia 1.0
Blood and lymphatic system disorders Thrombocytopenia 0.529

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
14.96
Gastrointestinal disorders
9.7
Nervous system disorders
8.52
Investigations
8.16
Skin and subcutaneous tissue disorders
7.42
Psychiatric disorders
6.4
Blood and lymphatic system disorders
6.14
Vascular disorders
4.38
Respiratory, thoracic and mediastinal disorders
4.33
Hepatobiliary disorders
4.32
Cardiac disorders
4.1
Infections and infestations
4.06
Musculoskeletal and connective tissue disorders
3.66
Injury, poisoning and procedural complications
3.22
Metabolism and nutrition disorders
3.09

Cross References

Resources Reference
CAS NUMBER 36791-04-5
ChEBI 63580
ChEMBL CHEMBL1643
DrugBank DB00811
DrugCentral 2373
EPA CompTox DTXSID8023557
FDA SRS 49717AWG6K
Human Metabolome Database HMDB0014949
Guide to Pharmacology 6842
PDB RBV
PharmGKB PA451241
PubChem 37542
SureChEMBL SCHEMBL3727
ZINC ZINC000001035331
CONTENTS