| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1971) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| UNII: | VJT6J7R4TR |
Structure
| InChI Key | JQXXHWHPUNPDRT-WLSIYKJHSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C43H58N4O12 |
| Molecular Weight | 822.95 |
| AlogP | 4.34 |
| Hydrogen Bond Acceptor | 15.0 |
| Hydrogen Bond Donor | 6.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 220.15 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 59.0 |
Pharmacology
Metabolites
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Tuberculosis, Pulmonary | 4 | D014397 | ClinicalTrials |
| Alzheimer Disease | 3 | D000544 | ClinicalTrials |
| Multiple System Atrophy | 3 | D019578 | ClinicalTrials |
| Arthritis, Reactive | 3 | D016918 | ClinicalTrials |
| Diarrhea | 3 | D003967 | ClinicalTrials |
| Leprosy | 3 | D007918 | ClinicalTrials |
| Endocarditis | 3 | D004696 | ClinicalTrials |
| Infections | 3 | D007239 | ClinicalTrials |
| Enterocolitis, Pseudomembranous | 3 | D004761 | ClinicalTrials |
| Acquired Immunodeficiency Syndrome | 2 | D000163 | ClinicalTrials |
| Mycobacterium avium-intracellulare Infection | 2 | D015270 | ClinicalTrials |
| Cystic Fibrosis | 2 | D003550 | ClinicalTrials |
| Sarcoidosis | 2 | D012507 | ClinicalTrials |
| Onchocerciasis | 2 | D009855 | ClinicalTrials |
| Meningitis | 2 | D008581 | ClinicalTrials |
| Multiple Sclerosis | 2 | D009103 | ClinicalTrials |
| Lymphoma, Non-Hodgkin | 1 | D008228 | ClinicalTrials |
| Nausea | 1 | D009325 | ClinicalTrials |
| Non-alcoholic Fatty Liver Disease | 1 | D065626 | ClinicalTrials |
| Essential Hypertension | 1 | D000075222 | ClinicalTrials |
| Sepsis | 1 | D018805 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
| Respiratory Syncytial Virus Infections | 1 | D018357 | ClinicalTrials |
| Hepatitis B, Chronic | 1 | D019694 | ClinicalTrials |
| Renal Insufficiency | 1 | D051437 | ClinicalTrials |
| Mycoses | 1 | D009181 | ClinicalTrials |
| Coronary Disease | 1 | D003327 | ClinicalTrials |
| Renal Insufficiency, Chronic | 1 | D051436 | ClinicalTrials |
| Thrombosis | 1 | D013927 | ClinicalTrials |
| Melanoma | 1 | D008545 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 1 | D002289 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Constipation | 1 | D003248 | ClinicalTrials |
| Lymphoma | 1 | D008223 | ClinicalTrials |
| Leukemia, Lymphocytic, Chronic, B-Cell | 1 | D015451 | ClinicalTrials |
| Hodgkin Disease | 1 | D006689 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Diabetes Mellitus | 1 | D003920 | ClinicalTrials |
| Arthritis, Rheumatoid | 1 | D001172 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
| Endometriosis | 1 | D004715 | ClinicalTrials |
| Diabetes Mellitus, Type 2 | 1 | D003924 | ClinicalTrials |
| Hypertension, Pulmonary | 1 | D006976 | ClinicalTrials |
| Parkinson Disease | 1 | D010300 | ClinicalTrials |
| Melanoma | 1 | D008545 | ClinicalTrials |
| Rhinoscleroma | 0 | D012226 | ClinicalTrials |
| Osteomyelitis | 0 | D010019 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 13292-46-1 |
| ChEBI | 28077 |
| ChEMBL | CHEMBL374478 |
| DrugBank | DB01045 |
| EPA CompTox | DTXSID6021244 |
| FDA SRS | VJT6J7R4TR |
| Guide to Pharmacology | 2765 |
| KEGG | C06688 |
| PDB | RFP |
| PubChem | 135398735 |
| SureChEMBL | SCHEMBL23490 |
| ZINC | ZINC000169621223 |
CONTENTS