RILPIVIRINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2011)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 212WAX8KDD
Parent Compound: RILPIVIRINE

Structure
InChI Key KZVVGZKAVZUACK-BJILWQEISA-N
Smile Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Nc2ccc(C#N)cc2)n1.Cl
InChI
InChI=1S/C22H18N6.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19;/h3-9,11-13H,1-2H3,(H2,25,26,27,28);1H/b4-3+;

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H19ClN6
Molecular Weight 402.89
AlogP 4.99
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 97.42
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Human immunodeficiency virus type 1 reverse transcriptase inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Parent
Mixture
Mixture
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
10.45
Injury, poisoning and procedural complications
8.87
General disorders and administration site conditions
8.55
Gastrointestinal disorders
7.07
Metabolism and nutrition disorders
6.02
Pregnancy, puerperium and perinatal conditions
5.81
Psychiatric disorders
5.81
Vascular disorders
5.39
Investigations
5.17
Hepatobiliary disorders
4.33
Renal and urinary disorders
4.22
Infections and infestations
3.59
Skin and subcutaneous tissue disorders
3.59
Respiratory, thoracic and mediastinal disorders
3.48
Musculoskeletal and connective tissue disorders
2.85
Cardiac disorders
2.64
Endocrine disorders
2.22
Surgical and medical procedures
2.22

Cross References

Resources Reference
ChEBI 68602
ChEMBL CHEMBL1628504
EPA CompTox DTXSID80220320
FDA SRS 212WAX8KDD
PubChem 11711114
SureChEMBL SCHEMBL1831067
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