DrugMapper


Trade Names:	PERSERIS KIT RISPERDAL RISPERDAL CONSTA RISPERIDONE
Synonyms:	LY-03004 LY03004 N05AX08 NSC-759895 Perseris Perseris kit R 64 766 R-64,766 R-64-766 R-64766 RCN-3028 RCN3028 Risperdal Risperdal consta Risperdal Consta Long Acting Risperdal M Risperdal M-Tab Risperdal quicklet Risperidone
Status:	Approved (1993)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	N05AX08
UNII:	L6UH7ZF8HC


InChI Key	RAPZEAPATHNIPO-UHFFFAOYSA-N
Smile	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2
InChI	InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

Property Name	Value
Molecular Formula	C23H27FN4O2
Molecular Weight	410.49
AlogP	3.59
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	4.0
Polar Surface Area	64.16
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	30.0

Action	Mechanism of Action	Reference
ANTAGONIST	Dopamine D2 receptor antagonist	FDA

	Primary Target
5-HT_1B receptor
5-HT_1D receptor
5-HT_2A receptor
D₂ receptor

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel Glycine receptor	320	-	-	-	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	148-1330	-	920	-
Ion channel Voltage-gated ion channel Voltage-gated calcium channel	-	73000-73000	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	-	-	2800	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	10-11	-	1-58	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	4-38	-	2-19	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	454-868	-	8-46	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	2-7	398	0-1	-
Membrane receptor	-	4-38	398	2-19	-
Secreted protein	-	-	43800	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	-	-	1400	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	11000	-	-	39
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters	-	1600	-	-	-

Mesh Heading	Maximum Phase	Mesh ID	Reference
Psychotic Disorders	4	D011618	ClinicalTrials
Developmental Disabilities	3	D002658	ClinicalTrials
Neurodevelopmental Disorders	3	D065886	ClinicalTrials
Asperger Syndrome	3	D020817	ClinicalTrials
Depressive Disorder, Major	3	D003865	ClinicalTrials
Anxiety	3	D001007	ClinicalTrials
Depressive Disorder	3	D003866	ClinicalTrials
Depressive Disorder	3	D003866	ClinicalTrials
Dementia	3	D003704	ClinicalTrials
Attention Deficit and Disruptive Behavior Disorders	3	D019958	ClinicalTrials
Rett Syndrome	3	D015518	ClinicalTrials
Dementia, Vascular	3	D015140	ClinicalTrials
Conduct Disorder	3	D019955	ClinicalTrials
Alzheimer Disease	3	D000544	ClinicalTrials
Intellectual Disability	3	D008607	ClinicalTrials
Amphetamine-Related Disorders	2	D019969	ClinicalTrials
Stress Disorders, Post-Traumatic	2	D013313	ClinicalTrials
Child Development Disorders, Pervasive	2	D002659	ClinicalTrials
Tourette Syndrome	2	D005879	ClinicalTrials
Cocaine-Related Disorders	2	D019970	ClinicalTrials
Huntington Disease	1	D006816	ClinicalTrials
Lecithin Cholesterol Acyltransferase Deficiency	1	D007863	ClinicalTrials
Dyskinesia, Drug-Induced	1	D004409	ClinicalTrials
Schizotypal Personality Disorder	1	D012569	ClinicalTrials
Substance-Related Disorders	0	D019966	ClinicalTrials
Opioid-Related Disorders	0	D009293	ClinicalTrials

Side Effects (PT)

Side effects	Relative Frequency (%)	Labels
Nervous system disorders Somnolence	67.0
Vascular disorders Angiopathy
Nervous system disorders Somnolence	56.0
Vascular disorders Angiopathy	55.0
Vascular disorders Angiopathy	54.0
Skin and subcutaneous tissue disorders Skin disorder
Skin and subcutaneous tissue disorders Skin disorder	52.0
Skin and subcutaneous tissue disorders Skin disorder	51.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder
General disorders and administration site conditions Increased appetite	49.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder	49.0
Nervous system disorders Somnolence	49.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder	48.0
Reproductive system and breast disorders Breast disorder
General disorders and administration site conditions Increased appetite	47.0
Nervous system disorders Neuropathy peripheral	46.1
Reproductive system and breast disorders Breast disorder	46.0
Reproductive system and breast disorders Breast disorder	45.0
General disorders and administration site conditions Increased appetite	44.0
Metabolism and nutrition disorders Malnutrition	44.0
Renal and urinary disorders Urethral disorder
Renal and urinary disorders Urinary tract disorder
Renal and urinary disorders Urethral disorder	43.0
Renal and urinary disorders Urinary tract disorder	43.0
General disorders and administration site conditions Asthenia	42.0
General disorders and administration site conditions Fatigue	42.0
Nervous system disorders Somnolence	42.0
Renal and urinary disorders Urethral disorder	42.0
Renal and urinary disorders Urinary tract disorder	42.0
Psychiatric disorders Mental disorder
Psychiatric disorders Mental disorder	40.0
Psychiatric disorders Mental disorder	39.0
Nervous system disorders Nervous system disorder
Nervous system disorders Insomnia
Nervous system disorders Nervous system disorder	37.0
Nervous system disorders Nervous system disorder	36.0
Infections and infestations Rhinitis	36.0
Musculoskeletal and connective tissue disorders Connective tissue disorder
Musculoskeletal and connective tissue disorders Connective tissue disorder	34.0
Nervous system disorders Extrapyramidal disorder	34.0
Infections and infestations Upper respiratory tract infection	34.0
Musculoskeletal and connective tissue disorders Connective tissue disorder	33.0
Nervous system disorders Insomnia	32.0
Metabolism and nutrition disorders Malnutrition
General disorders and administration site conditions Asthenia	31.0
General disorders and administration site conditions Fatigue	31.0
Metabolism and nutrition disorders Malnutrition	31.0
General disorders and administration site conditions Asthenia	30.0
General disorders and administration site conditions Fatigue	30.0
Metabolism and nutrition disorders Malnutrition	30.0
Nervous system disorders Somnolence	30.0
Nervous system disorders Parkinsonism	28.0
Nervous system disorders Somnolence	28.0
Nervous system disorders Insomnia
Nervous system disorders Somnolence	27.0
Nervous system disorders Somnolence	26.5
Nervous system disorders Agitation	26.0
Infections and infestations Infection
Infections and infestations Infestation
Nervous system disorders Insomnia	26.0
Nervous system disorders Parkinsonism	26.0
Nervous system disorders Insomnia	25.3
Infections and infestations Infection	25.0
Infections and infestations Infestation	25.0
Nervous system disorders Insomnia	25.0
Nervous system disorders Parkinsonism	25.0
Nervous system disorders Somnolence	25.0
Gastrointestinal disorders Vomiting	25.0
Nervous system disorders Neuropathy peripheral
Respiratory, thoracic and mediastinal disorders Cough	24.0
Infections and infestations Infection	24.0
Infections and infestations Infestation	24.0
Nervous system disorders Somnolence	24.0
Nervous system disorders Tremor	24.0
Psychiatric disorders Mental disorder	23.7
Immune system disorders Immune system disorder
Nervous system disorders Insomnia	23.0
Infections and infestations Rhinitis
Nervous system disorders Somnolence
Nervous system disorders Tremor	23.0
Nervous system disorders Headache	22.4
Nervous system disorders Agitation	22.0
Nervous system disorders Extrapyramidal disorder	22.0
Immune system disorders Immune system disorder	22.0
Gastrointestinal disorders Salivary hypersecretion	22.0
Nervous system disorders Somnolence	22.0
Nervous system disorders Urinary incontinence	22.0
Nervous system disorders Headache	21.1
Gastrointestinal disorders Constipation	21.0
Nervous system disorders Headache	21.0
Immune system disorders Immune system disorder	21.0
Infections and infestations Nasopharyngitis	21.0
Gastrointestinal disorders Vomiting
Nervous system disorders Agitation
Psychiatric disorders Anxiety	20.0
General disorders and administration site conditions Asthenia	20.0
Investigations Body temperature increased	20.0
General disorders and administration site conditions Fatigue	20.0
Nervous system disorders Parkinsonism	20.0
Nervous system disorders Urinary incontinence
Gastrointestinal disorders Vomiting	20.0
Nervous system disorders Extrapyramidal disorder	19.6
Nervous system disorders Parkinsonism	19.3
General disorders and administration site conditions Asthenia	19.2
General disorders and administration site conditions Fatigue	19.2
Psychiatric disorders Mental disorder
General disorders and administration site conditions Asthenia
Investigations Body temperature increased
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Increased appetite
Nervous system disorders Insomnia
Infections and infestations Nasopharyngitis	19.0
Nervous system disorders Somnolence
General disorders and administration site conditions Asthenia	18.9
General disorders and administration site conditions Fatigue	18.9
Gastrointestinal disorders Abdominal pain	18.0
General disorders and administration site conditions Asthenia	18.0
Respiratory, thoracic and mediastinal disorders Cough
General disorders and administration site conditions Fatigue	18.0
Gastrointestinal disorders Gastrointestinal pain	18.0
Cardiac disorders Oedema peripheral	18.0
Nervous system disorders Somnolence
General disorders and administration site conditions Increased appetite	17.2
Nervous system disorders Parkinsonism	17.2
Gastrointestinal disorders Constipation	17.0
Respiratory, thoracic and mediastinal disorders Cough	17.0
Nervous system disorders Extrapyramidal disorder	17.0
Gastrointestinal disorders Gastrointestinal disorder
Nervous system disorders Nervous system disorder	17.0
Nervous system disorders Parkinsonism	17.0
Nervous system disorders Somnolence	17.0
Gastrointestinal disorders Vomiting
Nervous system disorders Insomnia	16.2
Gastrointestinal disorders Abdominal pain upper	16.0
Nervous system disorders Agitation
Nervous system disorders Akathisia	16.0
Psychiatric disorders Anxiety	16.0
Investigations Body temperature increased	16.0
Cardiac disorders Dizziness	16.0
Nervous system disorders Drooling	16.0
Gastrointestinal disorders Dyspepsia	16.0
Psychiatric disorders Enuresis	16.0
Nervous system disorders Extrapyramidal disorder
Gastrointestinal disorders Gastrointestinal disorder	16.0
Infections and infestations Nasopharyngitis	16.0
Gastrointestinal disorders Nausea	16.0
Cardiac disorders Oedema peripheral	16.0
Nervous system disorders Parkinsonism	16.0
Respiratory, thoracic and mediastinal disorders Rhinorrhoea	16.0
Nervous system disorders Tremor
Renal and urinary disorders Urethral disorder	16.0
Renal and urinary disorders Urinary tract disorder	16.0
Nervous system disorders Somnolence	15.8
Gastrointestinal disorders Abdominal pain	15.0
Psychiatric disorders Anxiety
Gastrointestinal disorders Dry mouth	15.0
Gastrointestinal disorders Gastrointestinal disorder	15.0
Gastrointestinal disorders Gastrointestinal pain	15.0
Nervous system disorders Headache
Nervous system disorders Headache	15.0
General disorders and administration site conditions Increased appetite
Metabolism and nutrition disorders Malnutrition
Nervous system disorders Parkinsonism	15.0
Infections and infestations Upper respiratory tract infection
Nervous system disorders Headache
Cardiac disorders Dizziness	14.0
Eye disorders Eye disorder
Nervous system disorders Headache	14.0
Nervous system disorders Insomnia
Nervous system disorders Nervous system disorder	14.0
Nervous system disorders Parkinsonism	14.0
Infections and infestations Rhinitis	14.0
Nervous system disorders Somnolence	14.0
Cardiac disorders Dizziness	13.7
Gastrointestinal disorders Vomiting	13.7
Nervous system disorders Insomnia
Gastrointestinal disorders Abdominal pain upper	13.0
General disorders and administration site conditions Asthenia
Investigations Body temperature increased
Gastrointestinal disorders Constipation	13.0
Cardiac disorders Dizziness	13.0
Gastrointestinal disorders Dry mouth	13.0
Nervous system disorders Extrapyramidal disorder	13.0
Eye disorders Eye disorder	13.0
General disorders and administration site conditions Fatigue
Respiratory, thoracic and mediastinal disorders Nasal congestion	13.0
Infections and infestations Nasopharyngitis
Gastrointestinal disorders Nausea	13.0
Cardiac disorders Oedema peripheral	13.0
Nervous system disorders Parkinsonism	13.0
Infections and infestations Rhinitis	13.0
Respiratory, thoracic and mediastinal disorders Rhinorrhoea
Infections and infestations Urinary tract infection	12.9
Nervous system disorders Somnolence	12.2
Psychiatric disorders Anxiety	12.0
Respiratory, thoracic and mediastinal disorders Cough
Nervous system disorders Drooling	12.0
Eye disorders Eye disorder	12.0
Nervous system disorders Headache
Nervous system disorders Headache	12.0
Infections and infestations Nasopharyngitis	12.0
Nervous system disorders Parkinsonism	12.0
Respiratory, thoracic and mediastinal disorders Rhinorrhoea	12.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	12.0
Nervous system disorders Tremor	12.0
Gastrointestinal disorders Vomiting	12.0
Psychiatric disorders Anxiety	11.1
Nervous system disorders Akathisia	11.0
Psychiatric disorders Anxiety
Psychiatric disorders Anxiety	11.0
Skin and subcutaneous tissue disorders Dermatitis	11.0
Cardiac disorders Dizziness	11.0
Gastrointestinal disorders Dyspepsia	11.0
Musculoskeletal and connective tissue disorders Muscle rigidity	11.0
Gastrointestinal disorders Nausea	11.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	11.0
Skin and subcutaneous tissue disorders Rash	11.0
Infections and infestations Rhinitis	11.0
Nervous system disorders Somnolence	11.0
Nervous system disorders Tremor	11.0
Infections and infestations Urinary tract infection
Nervous system disorders Akathisia	10.1
Nervous system disorders Akathisia	10.0
Cardiac disorders Dizziness	10.0
Gastrointestinal disorders Dry mouth	10.0
Gastrointestinal disorders Dyspepsia	10.0
Psychiatric disorders Enuresis
Psychiatric disorders Erectile dysfunction	10.0
Gastrointestinal disorders Gastrointestinal disorder	10.0
Nervous system disorders Headache
Respiratory, thoracic and mediastinal disorders Laryngeal pain	10.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder	10.0
Respiratory, thoracic and mediastinal disorders Nasal congestion	10.0
Infections and infestations Nasopharyngitis
General disorders and administration site conditions Pain	10.0
Nervous system disorders Parkinsonism	10.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	10.0
Respiratory, thoracic and mediastinal disorders Rhinorrhoea
Gastrointestinal disorders Salivary hypersecretion	10.0
Nervous system disorders Somnolence	10.0
Nervous system disorders Tremor	10.0
Renal and urinary disorders Urethral disorder
Renal and urinary disorders Urinary tract disorder
Gastrointestinal disorders Vomiting	10.0
Nervous system disorders Akathisia	9.8
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Constipation	9.1
Nervous system disorders Agitation	9.0
Nervous system disorders Akathisia	9.0
Psychiatric disorders Anxiety
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia	9.0
Gastrointestinal disorders Constipation	9.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	9.0
Gastrointestinal disorders Dyspepsia	9.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue	9.0
Infections and infestations Nasopharyngitis
Gastrointestinal disorders Nausea	9.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	9.0
Infections and infestations Rhinitis	9.0
Gastrointestinal disorders Salivary hypersecretion	9.0
Nervous system disorders Headache	8.99
Respiratory, thoracic and mediastinal disorders Cough	8.7
Nervous system disorders Agitation	8.53
Nervous system disorders Hyperkinesia	8.53
Gastrointestinal disorders Abdominal pain upper	8.4
Investigations Body temperature increased	8.4
Nervous system disorders Tremor	8.4
Gastrointestinal disorders Vomiting	8.4
Cardiac disorders Dizziness	8.1
Nervous system disorders Agitation	8.0
Nervous system disorders Akathisia	8.0
Psychiatric disorders Anxiety	8.0
Cardiac disorders Cardiac disorder
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation	8.0
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite	8.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis	8.0
Gastrointestinal disorders Diarrhoea	8.0
Cardiac disorders Dizziness	8.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	8.0
Nervous system disorders Extrapyramidal disorder
Nervous system disorders Insomnia
Psychiatric disorders Mania	8.0
Psychiatric disorders Mental disorder	8.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	8.0
Nervous system disorders Nervous system disorder
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	8.0
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash	8.0
Infections and infestations Respiratory tract infection	8.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	8.0
Skin and subcutaneous tissue disorders Skin disorder	8.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	8.0
Nervous system disorders Tremor	8.0
Infections and infestations Upper respiratory tract infection	8.0
Investigations Weight increased	8.0
Nervous system disorders Parkinsonism
Psychiatric disorders Anxiety	7.7
Cardiac disorders Oedema peripheral	7.7
Nervous system disorders Somnolence
Psychiatric disorders Erectile dysfunction	7.69
General disorders and administration site conditions Lethargy	7.6
Nervous system disorders Headache
General disorders and administration site conditions Increased appetite
Endocrine disorders Amenorrhoea
Psychiatric disorders Erectile dysfunction
Endocrine disorders Gynaecomastia
Nervous system disorders Agitation	7.0
Nervous system disorders Akathisia	7.0
Psychiatric disorders Anxiety
Psychiatric disorders Anxiety	7.0
General disorders and administration site conditions Asthenia	7.0
Psychiatric disorders Automatism	7.0
Cardiac disorders Cardiac disorder	7.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation	7.0
Skin and subcutaneous tissue disorders Dermatitis	7.0
Gastrointestinal disorders Diarrhoea	7.0
Cardiac disorders Dizziness	7.0
Gastrointestinal disorders Dry mouth	7.0
Nervous system disorders Dyskinesia	7.0
Gastrointestinal disorders Dyspepsia	7.0
Nervous system disorders Extrapyramidal disorder
Nervous system disorders Extrapyramidal disorder	7.0
Eye disorders Eye disorder	7.0
General disorders and administration site conditions Fatigue	7.0
Nervous system disorders Hypokinesia	7.0
General disorders and administration site conditions Increased appetite	7.0
Metabolism and nutrition disorders Malnutrition	7.0
Psychiatric disorders Mental disorder	7.0
Gastrointestinal disorders Nausea
Nervous system disorders Parkinsonism	7.0
Skin and subcutaneous tissue disorders Rash	7.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	7.0
Gastrointestinal disorders Salivary hypersecretion	7.0
Skin and subcutaneous tissue disorders Skin disorder	7.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	7.0
Cardiac disorders Tachycardia	7.0
General disorders and administration site conditions Thirst	7.0
Eye disorders Vision blurred	7.0
Eye disorders Visual impairment	7.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting	7.0
Investigations Weight increased	7.0
Nervous system disorders Somnolence	6.8
Gastrointestinal disorders Diarrhoea	6.7
Respiratory, thoracic and mediastinal disorders Cough
Nervous system disorders Tremor	6.45
Endocrine disorders Amenorrhoea	6.41
Psychiatric disorders Enuresis	6.4
Gastrointestinal disorders Nausea	6.4
Gastrointestinal disorders Abdominal pain upper	6.3
Investigations Body temperature increased
Cardiac disorders Dizziness	6.3
Gastrointestinal disorders Salivary hypersecretion	6.3
Endocrine disorders Amenorrhoea	6.12
Psychiatric disorders Erectile dysfunction	6.12
Nervous system disorders Extrapyramidal disorder
Gastrointestinal disorders Dyspepsia	6.1
Respiratory, thoracic and mediastinal disorders Nasal congestion	6.1
Nervous system disorders Tremor	6.1
Gastrointestinal disorders Abdominal discomfort	6.0
Gastrointestinal disorders Abdominal pain	6.0
Nervous system disorders Agitation
Nervous system disorders Agitation	6.0
Nervous system disorders Akathisia
Nervous system disorders Akathisia	6.0
Psychiatric disorders Anxiety	6.0
General disorders and administration site conditions Asthenia	6.0
Investigations Body temperature increased	6.0
Cardiac disorders Cardiac disorder	6.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation	6.0
General disorders and administration site conditions Decreased appetite	6.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea	6.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	6.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth	6.0
Nervous system disorders Dyskinesia	6.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	6.0
Respiratory, thoracic and mediastinal disorders Epistaxis	6.0
General disorders and administration site conditions Fatigue	6.0
Gastrointestinal disorders Gastrointestinal pain	6.0
Nervous system disorders Headache	6.0
Psychiatric disorders Mania
Psychiatric disorders Mania	6.0
Psychiatric disorders Mental disorder	6.0
Musculoskeletal and connective tissue disorders Muscle rigidity	6.0
Respiratory, thoracic and mediastinal disorders Nasal congestion	6.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	6.0
Cardiac disorders Oedema peripheral
Musculoskeletal and connective tissue disorders Pain in extremity	6.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	6.0
Gastrointestinal disorders Pharyngitis	6.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	6.0
Gastrointestinal disorders Salivary hypersecretion
Gastrointestinal disorders Salivary hypersecretion	6.0
Nervous system disorders Tremor
Nervous system disorders Tremor	6.0
Infections and infestations Upper respiratory tract infection	6.0
Nervous system disorders Urinary incontinence	6.0
Gastrointestinal disorders Vomiting
Cardiac disorders Dizziness	5.53
Psychiatric disorders Enuresis
Infections and infestations Infection	5.2
Infections and infestations Upper respiratory tract infection	5.2
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Abdominal pain upper
Nervous system disorders Akathisia	5.0
Nervous system disorders Confusional state	5.0
Gastrointestinal disorders Constipation	5.0
Respiratory, thoracic and mediastinal disorders Cough	5.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis	5.0
Gastrointestinal disorders Diarrhoea	5.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	5.0
Nervous system disorders Drooling
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	5.0
Cardiac disorders Dyspnoea	5.0
General disorders and administration site conditions Feeling abnormal	5.0
Endocrine disorders Galactorrhoea	5.0
Gastrointestinal disorders Gastrointestinal pain
Psychiatric disorders Hallucination
Vascular disorders Hypotension	5.0
Respiratory, thoracic and mediastinal disorders Laryngeal pain
Respiratory, thoracic and mediastinal disorders Laryngeal pain	5.0
General disorders and administration site conditions Lethargy	5.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	5.0
Musculoskeletal and connective tissue disorders Myalgia	5.0
Respiratory, thoracic and mediastinal disorders Nasal congestion
Respiratory, thoracic and mediastinal disorders Nasal congestion	5.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	5.0
General disorders and administration site conditions Pain	5.0
Gastrointestinal disorders Pharyngitis	5.0
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash	5.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	5.0
Gastrointestinal disorders Salivary hypersecretion	5.0
Skin and subcutaneous tissue disorders Skin disorder
Nervous system disorders Somnolence
Nervous system disorders Somnolence	5.0
Cardiac disorders Tachycardia	5.0
Nervous system disorders Tremor	5.0
Nervous system disorders Urinary incontinence	5.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting	5.0
Investigations Weight increased	5.0
General disorders and administration site conditions Asthenia
Nervous system disorders Drooling	4.9
General disorders and administration site conditions Fatigue
Infections and infestations Nasopharyngitis	4.9
Respiratory, thoracic and mediastinal disorders Rhinorrhoea	4.9
Investigations Weight increased	4.9
Cardiac disorders Dizziness
Nervous system disorders Somnolence	4.8
Gastrointestinal disorders Abdominal pain upper
Gastrointestinal disorders Constipation	4.6
Respiratory, thoracic and mediastinal disorders Cough	4.6
Skin and subcutaneous tissue disorders Erythema
Gastrointestinal disorders Vomiting	4.5
Endocrine disorders Amenorrhoea	4.44
Psychiatric disorders Anxiety
Gastrointestinal disorders Dyspepsia	4.3
Respiratory, thoracic and mediastinal disorders Epistaxis	4.2
Nervous system disorders Tremor	4.2
Gastrointestinal disorders Nausea	4.15
Nervous system disorders Parkinsonism	4.1
Gastrointestinal disorders Abdominal pain	4.0
Nervous system disorders Akathisia
Nervous system disorders Akathisia	4.0
Endocrine disorders Amenorrhoea	4.0
Psychiatric disorders Anxiety	4.0
Musculoskeletal and connective tissue disorders Arthralgia	4.0
General disorders and administration site conditions Asthenia	4.0
Musculoskeletal and connective tissue disorders Back pain	4.0
Investigations Body temperature increased	4.0
Nervous system disorders Confusional state	4.0
Gastrointestinal disorders Constipation	4.0
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough	4.0
Skin and subcutaneous tissue disorders Dermatitis	4.0
Gastrointestinal disorders Diarrhoea
Nervous system disorders Disturbance in attention	4.0
Cardiac disorders Dizziness	4.0
Nervous system disorders Drooling
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth	4.0
Skin and subcutaneous tissue disorders Dry skin	4.0
Nervous system disorders Dyskinesia	4.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	4.0
Psychiatric disorders Erectile dysfunction	4.0
Skin and subcutaneous tissue disorders Erythema	4.0
Eye disorders Eye disorder	4.0
General disorders and administration site conditions Fatigue	4.0
General disorders and administration site conditions Feeling abnormal	4.0
General disorders and administration site conditions Gait disturbance	4.0
Gastrointestinal disorders Gastrointestinal pain	4.0
General disorders and administration site conditions Increased appetite	4.0
Nervous system disorders Insomnia	4.0
Metabolism and nutrition disorders Malnutrition	4.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	4.0
Respiratory, thoracic and mediastinal disorders Nasal congestion
Respiratory, thoracic and mediastinal disorders Nasal congestion	4.0
Infections and infestations Nasopharyngitis	4.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	4.0
General disorders and administration site conditions Pain
General disorders and administration site conditions Pain	4.0
Musculoskeletal and connective tissue disorders Pain in extremity	4.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	4.0
Gastrointestinal disorders Pharyngitis	4.0
Skin and subcutaneous tissue disorders Rash	4.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	4.0
Gastrointestinal disorders Salivary hypersecretion	4.0
Infections and infestations Sinusitis	4.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	4.0
Cardiac disorders Tachycardia	4.0
General disorders and administration site conditions Thirst
Gastrointestinal disorders Toothache	4.0
Gastrointestinal disorders Tooth disorder	4.0
Nervous system disorders Tremor
Eye disorders Vision blurred	4.0
Eye disorders Visual impairment	4.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting	4.0
Investigations Weight decreased	4.0
Investigations Weight increased	4.0
Cardiac disorders Dizziness
Cardiac disorders Oedema peripheral
Gastrointestinal disorders Vomiting	3.9
Investigations Blood prolactin increased	3.8
Respiratory, thoracic and mediastinal disorders Epistaxis	3.8
Respiratory, thoracic and mediastinal disorders Laryngeal pain	3.8
Gastrointestinal disorders Vomiting
Nervous system disorders Agitation	3.7
Nervous system disorders Extrapyramidal disorder	3.7
Gastrointestinal disorders Dyspepsia	3.69
Musculoskeletal and connective tissue disorders Hypertonia	3.69
Nervous system disorders Somnolence
Nervous system disorders Tremor
Gastrointestinal disorders Constipation
Skin and subcutaneous tissue disorders Dermatitis	3.5
Cardiac disorders Dizziness	3.5
General disorders and administration site conditions Gait disturbance	3.5
Skin and subcutaneous tissue disorders Rash	3.5
Infections and infestations Rhinitis	3.5
Gastrointestinal disorders Salivary hypersecretion	3.5
Nervous system disorders Extrapyramidal disorder	3.4
Infections and infestations Infection
Infections and infestations Nasopharyngitis
Respiratory, thoracic and mediastinal disorders Rhinorrhoea
Infections and infestations Upper respiratory tract infection
Cardiac disorders Cardiovascular disorder	3.23
Investigations Body temperature increased	3.2
Respiratory, thoracic and mediastinal disorders Cough	3.2
General disorders and administration site conditions Increased appetite	3.2
Infections and infestations Rhinitis
Respiratory, thoracic and mediastinal disorders Cough
Infections and infestations Pneumonia	3.1
Gastrointestinal disorders Abdominal discomfort	3.0
Gastrointestinal disorders Abdominal pain	3.0
Psychiatric disorders Aggression
Psychiatric disorders Aggression	3.0
Nervous system disorders Agitation	3.0
Nervous system disorders Akathisia
Nervous system disorders Akathisia	3.0
Psychiatric disorders Anxiety
Psychiatric disorders Anxiety	3.0
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Arthralgia	3.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia	3.0
Musculoskeletal and connective tissue disorders Back pain	3.0
Investigations Body temperature increased	3.0
Nervous system disorders Bradykinesia	3.0
Cardiac disorders Cardiac disorder	3.0
Cardiac disorders Chest pain	3.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation	3.0
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough	3.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea	3.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	3.0
Gastrointestinal disorders Dry mouth	3.0
Skin and subcutaneous tissue disorders Dry skin	3.0
Nervous system disorders Dyskinesia
Nervous system disorders Dyskinesia	3.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	3.0
Psychiatric disorders Erectile dysfunction	3.0
Eye disorders Eye disorder	3.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue	3.0
Gastrointestinal disorders Gastrointestinal pain	3.0
Nervous system disorders Headache	3.0
Nervous system disorders Hyperkinesia	3.0
Vascular disorders Hypertension	3.0
Vascular disorders Hypotension
Vascular disorders Hypotension	3.0
Respiratory, thoracic and mediastinal disorders Laryngeal pain	3.0
General disorders and administration site conditions Lethargy
Psychiatric disorders Mania	3.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder	3.0
Psychiatric disorders Mental disorder
Psychiatric disorders Mental disorder	3.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	3.0
Infections and infestations Nasopharyngitis
Infections and infestations Nasopharyngitis	3.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	3.0
Psychiatric disorders Nervousness
Cardiac disorders Oedema peripheral	3.0
Nervous system disorders Orthostatic hypotension	3.0
General disorders and administration site conditions Pain
General disorders and administration site conditions Pain	3.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	3.0
Gastrointestinal disorders Pharyngitis	3.0
Infections and infestations Respiratory tract infection
Infections and infestations Rhinitis
Infections and infestations Rhinitis	3.0
Gastrointestinal disorders Salivary hypersecretion	3.0
Infections and infestations Sinusitis	3.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	3.0
Psychiatric disorders Suicide attempt
Cardiac disorders Tachycardia	3.0
Psychiatric disorders Tension
Gastrointestinal disorders Toothache	3.0
Nervous system disorders Tremor
Nervous system disorders Tremor	3.0
Infections and infestations Upper respiratory tract infection
Infections and infestations Upper respiratory tract infection	3.0
Infections and infestations Urinary tract infection	3.0
Eye disorders Vision blurred	3.0
Eye disorders Visual acuity reduced	3.0
Eye disorders Visual impairment	3.0
Gastrointestinal disorders Vomiting
Cardiac disorders Cardiovascular disorder
Gastrointestinal disorders Abdominal discomfort	2.9
Nervous system disorders Parkinsonism	2.9
Nervous system disorders Akathisia
Nervous system disorders Confusional state	2.7
Eye disorders Conjunctivitis	2.7
General disorders and administration site conditions Feeling abnormal	2.7
Psychiatric disorders Mania
Investigations Body temperature increased	2.6
Gastrointestinal disorders Dyspepsia
General disorders and administration site conditions Lethargy	2.6
Gastrointestinal disorders Nausea
Nervous system disorders Parkinsonism	2.6
Endocrine disorders Gynaecomastia	2.56
Eye disorders Visual impairment	2.53
Nervous system disorders Agitation
Musculoskeletal and connective tissue disorders Arthralgia	2.5
Musculoskeletal and connective tissue disorders Back pain	2.5
Skin and subcutaneous tissue disorders Dry skin	2.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	2.5
Cardiac disorders Tachycardia	2.5
Nervous system disorders Tremor
Nervous system disorders Tremor	2.5
Infections and infestations Upper respiratory tract infection	2.5
Infections and infestations Urinary tract infection	2.5
Nervous system disorders Agitation
Nervous system disorders Hyperkinesia
Nervous system disorders Parkinsonism	2.4
Infections and infestations Pneumonia
Gastrointestinal disorders Abdominal pain	2.3
General disorders and administration site conditions Asthenia	2.3
General disorders and administration site conditions Decreased appetite	2.3
Gastrointestinal disorders Diarrhoea	2.3
Cardiac disorders Dizziness
General disorders and administration site conditions Fatigue	2.3
Gastrointestinal disorders Gastrointestinal pain	2.3
Gastrointestinal disorders Salivary hypersecretion	2.3
Endocrine disorders Galactorrhoea	2.22
Gastrointestinal disorders Dyspepsia
Vascular disorders Hypotension	2.2
General disorders and administration site conditions Lethargy
Musculoskeletal and connective tissue disorders Pain in extremity
Gastrointestinal disorders Abdominal pain	2.1
Gastrointestinal disorders Diarrhoea	2.1
Nervous system disorders Drooling	2.1
Gastrointestinal disorders Dry mouth	2.1
Nervous system disorders Extrapyramidal disorder	2.1
Endocrine disorders Galactorrhoea	2.1
Gastrointestinal disorders Gastrointestinal pain	2.1
Infections and infestations Infection	2.1
Respiratory, thoracic and mediastinal disorders Laryngeal pain	2.1
Infections and infestations Nasopharyngitis	2.1
Cardiac disorders Palpitations	2.1
Respiratory, thoracic and mediastinal disorders Rhinorrhoea	2.1
Infections and infestations Upper respiratory tract infection	2.1
Eye disorders Vision blurred	2.1
Investigations Weight increased	2.1
Vascular disorders Hypertension	2.07
Endocrine disorders Galactorrhoea	2.04
Gastrointestinal disorders Abdominal discomfort
Gastrointestinal disorders Abdominal discomfort	2.0
Gastrointestinal disorders Abdominal pain	2.0
Skin and subcutaneous tissue disorders Acne	2.0
Nervous system disorders Agitation
Nervous system disorders Agitation	2.0
Nervous system disorders Akathisia
Nervous system disorders Akathisia	2.0
Vascular disorders Angiopathy	2.0
Psychiatric disorders Anxiety
Psychiatric disorders Anxiety	2.0
Musculoskeletal and connective tissue disorders Arthralgia	2.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia	2.0
Musculoskeletal and connective tissue disorders Back pain	2.0
Investigations Blood creatine phosphokinase increased	2.0
Investigations Body temperature increased	2.0
Musculoskeletal and connective tissue disorders Bone pain	2.0
Cardiac disorders Cardiac disorder	2.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain	2.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation	2.0
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough	2.0
General disorders and administration site conditions Decreased appetite	2.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis	2.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea	2.0
Nervous system disorders Disturbance in attention	2.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	2.0
Cardiac disorders Dizziness postural	2.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth	2.0
Skin and subcutaneous tissue disorders Dry skin	2.0
Nervous system disorders Dyskinesia
Nervous system disorders Dyskinesia	2.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	2.0
Cardiac disorders Dyspnoea	2.0
Respiratory, thoracic and mediastinal disorders Epistaxis	2.0
Psychiatric disorders Erectile dysfunction	2.0
Eye disorders Eye disorder	2.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue	2.0
Endocrine disorders Galactorrhoea	2.0
Gastrointestinal disorders Gastrointestinal disorder
Gastrointestinal disorders Gastrointestinal pain	2.0
Nervous system disorders Hyperkinesia
Nervous system disorders Hyperkinesia	2.0
Vascular disorders Hypertension
Vascular disorders Hypertension	2.0
Nervous system disorders Hypoaesthesia	2.0
Vascular disorders Hypotension	2.0
General disorders and administration site conditions Increased appetite
Infections and infestations Infection	2.0
Infections and infestations Infestation	2.0
Respiratory, thoracic and mediastinal disorders Laryngeal pain
General disorders and administration site conditions Lethargy	2.0
Nervous system disorders Loss of consciousness	2.0
Metabolism and nutrition disorders Malnutrition
Social circumstances Mental disability
Social circumstances Mental disability	2.0
Psychiatric disorders Mental disorder
Musculoskeletal and connective tissue disorders Muscle rigidity
Musculoskeletal and connective tissue disorders Muscle rigidity	2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	2.0
Musculoskeletal and connective tissue disorders Myalgia
Musculoskeletal and connective tissue disorders Myalgia	2.0
Respiratory, thoracic and mediastinal disorders Nasal congestion
Respiratory, thoracic and mediastinal disorders Nasal congestion	2.0
Infections and infestations Nasopharyngitis	2.0
Gastrointestinal disorders Nausea
Psychiatric disorders Nervousness	2.0
Cardiac disorders Oedema peripheral	2.0
Nervous system disorders Orthostatic hypotension	2.0
General disorders and administration site conditions Pain
Musculoskeletal and connective tissue disorders Pain in extremity	2.0
Cardiac disorders Palpitations	2.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	2.0
Gastrointestinal disorders Pharyngitis
Gastrointestinal disorders Pharyngitis	2.0
Skin and subcutaneous tissue disorders Pruritus	2.0
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash	2.0
Infections and infestations Rhinitis
Infections and infestations Rhinitis	2.0
Gastrointestinal disorders Salivary hypersecretion
Gastrointestinal disorders Salivary hypersecretion	2.0
Skin and subcutaneous tissue disorders Seborrhoeic dermatitis	2.0
Vascular disorders Shock	2.0
Respiratory, thoracic and mediastinal disorders Sinus congestion	2.0
Infections and infestations Sinusitis	2.0
Skin and subcutaneous tissue disorders Skin disorder
Nervous system disorders Somnolence
Nervous system disorders Somnolence	2.0
Psychiatric disorders Suicide attempt	2.0
Cardiac disorders Syncope	2.0
Cardiac disorders Tachycardia
Cardiac disorders Tachycardia	2.0
Psychiatric disorders Tension	2.0
Nervous system disorders Thinking abnormal
Gastrointestinal disorders Toothache	2.0
Gastrointestinal disorders Tooth disorder	2.0
Nervous system disorders Tremor
Nervous system disorders Tremor	2.0
Infections and infestations Upper respiratory tract infection	2.0
Nervous system disorders Urinary incontinence	2.0
Infections and infestations Urinary tract infection	2.0
Infections and infestations Viral infection	2.0
Eye disorders Vision blurred	2.0
Eye disorders Visual impairment	2.0
Gastrointestinal disorders Vomiting	2.0
Investigations Weight increased
Investigations Weight increased	2.0
Vascular disorders Hypertension
Gastrointestinal disorders Diarrhoea
Nervous system disorders Somnolence
General disorders and administration site conditions Asthenia	1.84
General disorders and administration site conditions Fatigue	1.84
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	1.84
Musculoskeletal and connective tissue disorders Myalgia	1.84
General disorders and administration site conditions Pain	1.84
Eye disorders Visual impairment	1.84
Investigations Body temperature increased
Nervous system disorders Parkinsonism	1.8
Musculoskeletal and connective tissue disorders Posture abnormal	1.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Respiratory, thoracic and mediastinal disorders Epistaxis
Infections and infestations Influenza
Infections and infestations Influenza	1.7
Respiratory, thoracic and mediastinal disorders Laryngeal pain
Nervous system disorders Middle insomnia	1.7
Infections and infestations Nasopharyngitis
Nervous system disorders Parkinsonism	1.7
Musculoskeletal and connective tissue disorders Back pain
Nervous system disorders Transient ischaemic attack	1.6
Gastrointestinal disorders Abdominal discomfort	1.5
Musculoskeletal and connective tissue disorders Arthralgia	1.5
Investigations Blood creatine phosphokinase increased	1.5
Cardiac disorders Chest pain	1.5
Nervous system disorders Dysarthria	1.5
Gastrointestinal disorders Dysphagia	1.5
Respiratory, thoracic and mediastinal disorders Epistaxis	1.5
General disorders and administration site conditions Gait disturbance
Musculoskeletal and connective tissue disorders Joint swelling	1.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	1.5
Infections and infestations Nasopharyngitis	1.5
General disorders and administration site conditions Oedema	1.5
Musculoskeletal and connective tissue disorders Osteoarthritis	1.5
Renal and urinary disorders Pollakiuria	1.5
Respiratory, thoracic and mediastinal disorders Rhinorrhoea	1.5
Infections and infestations Sinusitis	1.5
Nervous system disorders Somnolence	1.5
Cardiac disorders Tachycardia	1.5
Infections and infestations Upper respiratory tract infection
Infections and infestations Upper respiratory tract infection	1.5
General disorders and administration site conditions Pain
Eye disorders Visual impairment
Gastrointestinal disorders Abdominal discomfort
Nervous system disorders Agitation	1.4
General disorders and administration site conditions Decreased appetite
Cardiac disorders Dizziness	1.4
Nervous system disorders Extrapyramidal disorder	1.4
Vascular disorders Hypotension
Gastrointestinal disorders Nausea	1.4
Nervous system disorders Urinary incontinence
Investigations Body temperature increased	1.38
Infections and infestations Rhinitis	1.38
Infections and infestations Sinusitis	1.38
Cardiac disorders Tachycardia	1.38
Nervous system disorders Altered state of consciousness	1.3
General disorders and administration site conditions Asthenia	1.3
Investigations Body temperature increased	1.3
Infections and infestations Cellulitis
Nervous system disorders Depressed level of consciousness	1.3
Nervous system disorders Drooling	1.3
Gastrointestinal disorders Dysphagia
General disorders and administration site conditions Lethargy
Respiratory, thoracic and mediastinal disorders Nasal congestion
Nervous system disorders Orthostatic hypotension	1.3
Endocrine disorders Galactorrhoea	1.28
Infections and infestations Rhinitis
Cardiac disorders Dizziness postural	1.2
Nervous system disorders Dyskinesia	1.2
Nervous system disorders Extrapyramidal disorder
General disorders and administration site conditions Feeling abnormal	1.2
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	1.2
Musculoskeletal and connective tissue disorders Myalgia	1.2
Musculoskeletal and connective tissue disorders Pain in extremity	1.2
Nervous system disorders Parkinsonism
Skin and subcutaneous tissue disorders Pruritus	1.2
Skin and subcutaneous tissue disorders Acne	1.15
Investigations Aspartate aminotransferase increased	1.15
General disorders and administration site conditions Asthenia	1.15
Gastrointestinal disorders Dry mouth	1.15
Endocrine disorders Galactorrhoea	1.15
Musculoskeletal and connective tissue disorders Muscle contractions involuntary	1.15
General disorders and administration site conditions Oedema	1.15
Gastrointestinal disorders Abdominal discomfort	1.1
Gastrointestinal disorders Abdominal pain	1.1
Skin and subcutaneous tissue disorders Acne	1.1
Nervous system disorders Agitation	1.1
Psychiatric disorders Apathy	1.1
General disorders and administration site conditions Balance disorder	1.1
Infections and infestations Cellulitis	1.1
Nervous system disorders Cerebrovascular accident	1.1
Cardiac disorders Chest discomfort	1.1
Cardiac disorders Chest pain	1.1
Eye disorders Conjunctivitis
Nervous system disorders Disturbance in attention	1.1
Nervous system disorders Drooling
Nervous system disorders Dysarthria	1.1
Psychiatric disorders Enuresis	1.1
Psychiatric disorders Flat affect	1.1
Gastrointestinal disorders Gastrointestinal pain	1.1
Nervous system disorders Hypersomnia	1.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	1.1
Musculoskeletal and connective tissue disorders Myalgia	1.1
Musculoskeletal and connective tissue disorders Neck pain	1.1
Musculoskeletal and connective tissue disorders Osteoarthritis	1.1
Renal and urinary disorders Pollakiuria	1.1
Cardiac disorders Pulmonary congestion	1.1
Respiratory, thoracic and mediastinal disorders Respiratory tract congestion	1.1
Infections and infestations Rhinitis	1.1
General disorders and administration site conditions Sluggishness	1.1
Cardiac disorders Tachycardia	1.1
Nervous system disorders Tremor
Endocrine disorders Gynaecomastia	1.02
Gastrointestinal disorders Abdominal discomfort
Gastrointestinal disorders Abdominal discomfort	1.0
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Abdominal pain	1.0
Gastrointestinal disorders Abdominal pain upper	1.0
Skin and subcutaneous tissue disorders Acne	1.0
Psychiatric disorders Aggression
Psychiatric disorders Aggression	1.0
Nervous system disorders Agitation	1.0
Nervous system disorders Akathisia	1.0
Endocrine disorders Amenorrhoea
Endocrine disorders Amenorrhoea	1.0
Blood and lymphatic system disorders Anaemia	1.0
Vascular disorders Angiopathy	1.0
Psychiatric disorders Anxiety	1.0
Cardiac disorders Arrhythmia	1.0
Musculoskeletal and connective tissue disorders Arthralgia
Investigations Aspartate aminotransferase increased
Investigations Aspartate aminotransferase increased	1.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia	1.0
Nervous system disorders Ataxia	1.0
Psychiatric disorders Automatism
Musculoskeletal and connective tissue disorders Back pain
Musculoskeletal and connective tissue disorders Back pain	1.0
General disorders and administration site conditions Balance disorder	1.0
Investigations Blood creatine phosphokinase increased
Investigations Blood creatine phosphokinase increased	1.0
Investigations Body temperature increased
Investigations Body temperature increased	1.0
Musculoskeletal and connective tissue disorders Bone pain
Musculoskeletal and connective tissue disorders Bone pain	1.0
Cardiac disorders Bundle branch block right	1.0
Cardiac disorders Cardiac disorder	1.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain	1.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation	1.0
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough	1.0
Skin and subcutaneous tissue disorders Dandruff	1.0
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite	1.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis	1.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea	1.0
Nervous system disorders Disturbance in attention
Nervous system disorders Disturbance in attention	1.0
Psychiatric disorders Disturbance in sexual arousal	1.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	1.0
Nervous system disorders Drooling	1.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth	1.0
Skin and subcutaneous tissue disorders Dry skin	1.0
Nervous system disorders Dyskinesia
Nervous system disorders Dyskinesia	1.0
Gastrointestinal disorders Dyspepsia	1.0
Cardiac disorders Dyspnoea
Cardiac disorders Dyspnoea	1.0
Ear and labyrinth disorders Ear pain	1.0
Reproductive system and breast disorders Ejaculation failure	1.0
Investigations Electrocardiogram QT prolonged	1.0
Respiratory, thoracic and mediastinal disorders Epistaxis	1.0
Psychiatric disorders Erectile dysfunction
Psychiatric disorders Erectile dysfunction	1.0
Eye disorders Eye disorder
Eye disorders Eye disorder	1.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue	1.0
Endocrine disorders Galactorrhoea	1.0
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Gastrointestinal pain	1.0
Endocrine disorders Gynaecomastia
Endocrine disorders Gynaecomastia	1.0
Endocrine disorders Hyperglycaemia	1.0
Skin and subcutaneous tissue disorders Hyperkeratosis
Skin and subcutaneous tissue disorders Hyperkeratosis	1.0
Immune system disorders Hypersensitivity	1.0
Vascular disorders Hypertension
Vascular disorders Hypertension	1.0
Nervous system disorders Hypoaesthesia
Nervous system disorders Hypokinesia
Nervous system disorders Hypokinesia	1.0
Vascular disorders Hypotension	1.0
Infections and infestations Infection
Infections and infestations Infestation
Musculoskeletal and connective tissue disorders Joint stiffness	1.0
General disorders and administration site conditions Lethargy
General disorders and administration site conditions Lethargy	1.0
Psychiatric disorders Libido decreased	1.0
Nervous system disorders Loss of consciousness
Nervous system disorders Loss of consciousness	1.0
Reproductive system and breast disorders Menstrual disorder	1.0
Social circumstances Mental disability
Social circumstances Mental disability	1.0
Musculoskeletal and connective tissue disorders Muscle rigidity	1.0
Musculoskeletal and connective tissue disorders Muscle twitching	1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	1.0
Musculoskeletal and connective tissue disorders Myalgia
Musculoskeletal and connective tissue disorders Myalgia	1.0
Infections and infestations Nasopharyngitis
Infections and infestations Nasopharyngitis	1.0
Gastrointestinal disorders Nausea	1.0
Psychiatric disorders Nervousness
Psychiatric disorders Nervousness	1.0
Eye disorders Oculogyric crisis
Eye disorders Oculogyric crisis	1.0
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema	1.0
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral	1.0
Nervous system disorders Orthostatic hypotension	1.0
General disorders and administration site conditions Pain	1.0
Musculoskeletal and connective tissue disorders Pain in extremity
Musculoskeletal and connective tissue disorders Pain in extremity	1.0
Cardiac disorders Palpitations	1.0
Nervous system disorders Parkinsonism
Nervous system disorders Parkinsonism	1.0
Musculoskeletal and connective tissue disorders Posture abnormal	1.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Pruritus	1.0
Psychiatric disorders Psychotic disorder	1.0
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash	1.0
Infections and infestations Rhinitis	1.0
Gastrointestinal disorders Salivary hypersecretion
Gastrointestinal disorders Salivary hypersecretion	1.0
Skin and subcutaneous tissue disorders Seborrhoeic dermatitis	1.0
Psychiatric disorders Sexual dysfunction	1.0
Vascular disorders Shock
Vascular disorders Shock	1.0
Respiratory, thoracic and mediastinal disorders Sinus congestion	1.0
Infections and infestations Sinusitis
Infections and infestations Sinusitis	1.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	1.0
Psychiatric disorders Suicide attempt
Psychiatric disorders Suicide attempt	1.0
Cardiac disorders Syncope
Cardiac disorders Syncope	1.0
Cardiac disorders Tachycardia
Cardiac disorders Tachycardia	1.0
Nervous system disorders Tardive dyskinesia	1.0
Psychiatric disorders Tension
Psychiatric disorders Tension	1.0
Gastrointestinal disorders Toothache	1.0
Nervous system disorders Tremor
Nervous system disorders Tremor	1.0
Infections and infestations Upper respiratory tract infection
Infections and infestations Upper respiratory tract infection	1.0
Nervous system disorders Urinary incontinence
Nervous system disorders Urinary incontinence	1.0
Infections and infestations Urinary tract infection
Infections and infestations Urinary tract infection	1.0
Eye disorders Vision blurred
Eye disorders Vision blurred	1.0
Eye disorders Visual impairment
Eye disorders Visual impairment	1.0
Investigations Weight decreased
Investigations Weight decreased	1.0
Investigations Weight increased
Investigations Weight increased	1.0
Gastrointestinal disorders Dry mouth
Musculoskeletal and connective tissue disorders Hypertonia
Gastrointestinal disorders Nausea
Gastrointestinal disorders Abdominal discomfort
Skin and subcutaneous tissue disorders Acne	0.9
Psychiatric disorders Apathy	0.9
General disorders and administration site conditions Balance disorder	0.9
Skin and subcutaneous tissue disorders Dermatitis
Nervous system disorders Disturbance in attention	0.9
Nervous system disorders Dyskinesia
Psychiatric disorders Flat affect	0.9
Nervous system disorders Hypersomnia
Nervous system disorders Middle insomnia
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Nervous system disorders Parkinsonism	0.9
Skin and subcutaneous tissue disorders Rash
Gastrointestinal disorders Salivary hypersecretion
General disorders and administration site conditions Sluggishness	0.9
Investigations Weight increased
Investigations Body temperature increased
Cardiac disorders Chest pain	0.8
Skin and subcutaneous tissue disorders Dermatitis	0.8
Cardiac disorders Dyspnoea	0.8
Infections and infestations Nasopharyngitis
Nervous system disorders Parkinsonism	0.8
Musculoskeletal and connective tissue disorders Posture abnormal
Skin and subcutaneous tissue disorders Rash	0.8
Respiratory, thoracic and mediastinal disorders Rhinorrhoea
Nervous system disorders Somnolence	0.8
Gastrointestinal disorders Vomiting	0.8
General disorders and administration site conditions Asthenia
Investigations Body temperature increased
General disorders and administration site conditions Fatigue
Eye disorders Visual impairment
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Abdominal pain upper	0.7
Investigations Body temperature increased
Cardiac disorders Dizziness	0.7
Gastrointestinal disorders Gastrointestinal pain
Infections and infestations Sinusitis	0.7
Eye disorders Vision blurred
Gastrointestinal disorders Abdominal discomfort
Gastrointestinal disorders Abdominal pain
Nervous system disorders Agitation	0.6
Musculoskeletal and connective tissue disorders Arthralgia
General disorders and administration site conditions Asthenia
Nervous system disorders Disturbance in attention
Endocrine disorders Galactorrhoea	0.6
Gastrointestinal disorders Gastrointestinal pain
Nervous system disorders Hyperkinesia	0.6
Nervous system disorders Hypersomnia	0.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Cardiac disorders Palpitations	0.6
Nervous system disorders Parkinsonism	0.6
Respiratory, thoracic and mediastinal disorders Sinus congestion
Infections and infestations Sinusitis
Nervous system disorders Transient ischaemic attack
Gastrointestinal disorders Abdominal pain	0.5
Nervous system disorders Agitation	0.5
General disorders and administration site conditions Asthenia	0.5
Gastrointestinal disorders Diarrhoea	0.5
Skin and subcutaneous tissue disorders Dry skin	0.5
Respiratory, thoracic and mediastinal disorders Epistaxis	0.5
Gastrointestinal disorders Gastrointestinal pain	0.5
Psychiatric disorders Nervousness	0.5
Nervous system disorders Orthostatic hypotension	0.5
Respiratory, thoracic and mediastinal disorders Sinus congestion	0.5
Nervous system disorders Somnolence	0.5
Cardiac disorders Tachycardia	0.5
Psychiatric disorders Tension	0.5
Infections and infestations Urinary tract infection	0.5
Gastrointestinal disorders Salivary hypersecretion
Cardiac disorders Tachycardia
Investigations Blood creatine phosphokinase increased	0.4
Nervous system disorders Cerebrovascular accident
Cardiac disorders Chest pain
Cardiac disorders Dizziness	0.4
Reproductive system and breast disorders Ejaculation failure	0.4
Eye disorders Eye disorder	0.4
Nervous system disorders Loss of consciousness	0.4
Psychiatric disorders Nervousness	0.4
Nervous system disorders Parkinsonism	0.4
Gastrointestinal disorders Salivary hypersecretion
Vascular disorders Shock	0.4
Cardiac disorders Syncope	0.4
Psychiatric disorders Tension	0.4
Nervous system disorders Akathisia	0.3
Nervous system disorders Altered state of consciousness
Investigations Blood prolactin increased
Cardiac disorders Chest discomfort	0.3
Cardiac disorders Chest pain	0.3
Nervous system disorders Depressed level of consciousness
Skin and subcutaneous tissue disorders Dry skin
Ear and labyrinth disorders Ear pain
Skin and subcutaneous tissue disorders Hyperkeratosis
Vascular disorders Hypotension
Nervous system disorders Insomnia	0.3
Musculoskeletal and connective tissue disorders Joint swelling
Gastrointestinal disorders Nausea	0.3
Musculoskeletal and connective tissue disorders Neck pain
Musculoskeletal and connective tissue disorders Neck pain	0.3
General disorders and administration site conditions Oedema
Nervous system disorders Orthostatic hypotension	0.3
Renal and urinary disorders Pollakiuria
Cardiac disorders Pulmonary congestion
Cardiac disorders Pulmonary congestion	0.3
Respiratory, thoracic and mediastinal disorders Respiratory tract congestion
Respiratory, thoracic and mediastinal disorders Respiratory tract congestion	0.3
Cardiac disorders Tachycardia	0.3
Nervous system disorders Urinary incontinence
Investigations Aspartate aminotransferase increased
Musculoskeletal and connective tissue disorders Muscle contractions involuntary
General disorders and administration site conditions Oedema
Infections and infestations Sinusitis
Investigations Alanine aminotransferase increased
Investigations Alanine aminotransferase increased	0.2
Investigations Aspartate aminotransferase increased
Investigations Aspartate aminotransferase increased	0.2
Skin and subcutaneous tissue disorders Dandruff	0.2
Cardiac disorders Dizziness	0.2
Vascular disorders Hypotension	0.2
General disorders and administration site conditions Lethargy	0.2
Skin and subcutaneous tissue disorders Seborrhoeic dermatitis	0.2
Nervous system disorders Somnolence	0.2
Cardiac disorders Tachycardia	0.2
Nervous system disorders Urinary incontinence	0.2
Gastrointestinal disorders Abdominal pain upper
Blood and lymphatic system disorders Anaemia
Blood and lymphatic system disorders Anaemia	0.1
Investigations Blood creatine phosphokinase increased
Nervous system disorders Confusional state
Cardiac disorders Dizziness postural
Ear and labyrinth disorders Ear pain	0.1
Respiratory, thoracic and mediastinal disorders Epistaxis
General disorders and administration site conditions Feeling abnormal
Immune system disorders Hypersensitivity
Immune system disorders Hypersensitivity	0.1
Psychiatric disorders Nervousness
Nervous system disorders Orthostatic hypotension
Cardiac disorders Tachycardia
Psychiatric disorders Tension
Infections and infestations Urinary tract infection

Resources	Reference
CAS NUMBER	106266-06-2
ChEBI	8871
ChEMBL	CHEMBL85
DrugBank	DB00734
DrugCentral	2389
EPA CompTox	DTXSID8045193
FDA SRS	L6UH7ZF8HC
Human Metabolome Database	HMDB0005020
Guide to Pharmacology	96
KEGG	D00426
PDB	8NU
PharmGKB	PA451257
PubChem	5073
SureChEMBL	SCHEMBL27911
ZINC	ZINC000000538312

RISPERIDONE

Structure

Physicochemical Descriptors

Pharmacology

Indications

Related Entries

MCS

Scaffolds

Side Effects from Label

Adverse Reactions

Cross References

	Relative Frequency (%)
Endocrine disorders	19.73
Reproductive system and breast disorders	17.14
Injury, poisoning and procedural complications	15.8
Psychiatric disorders	12.41
Metabolism and nutrition disorders	8.76
Nervous system disorders	6.65
General disorders and administration site conditions	5.28
Investigations	4.15


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70