Trade Names: | |
Synonyms: | |
Status: | Approved (2019) |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
ATC: | L01XX66 |
UNII: | 31TZ62FO8F |
InChI Key | DEVSOMFAQLZNKR-RJRFIUFISA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C17H11F6N7O |
Molecular Weight | 443.31 |
AlogP | 3.39 |
Hydrogen Bond Acceptor | 7.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 5.0 |
Polar Surface Area | 97.62 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 31.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Exportin-1 inhibitor | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Unclassified protein
|
- | - | 19 | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Neoplasms | 4 | D009369 | ClinicalTrials |
Neoplasms | 4 | D009369 | ClinicalTrials |
Endometrial Neoplasms | 3 | D016889 | ClinicalTrials |
Carcinoma, Squamous Cell | 2 | D002294 | ClinicalTrials |
Melanoma | 2 | D008545 | ClinicalTrials |
Glioblastoma | 2 | D005909 | ClinicalTrials |
Primary Myelofibrosis | 2 | D055728 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 2 | D045169 | ClinicalTrials |
Lymphoma | 2 | D008223 | ClinicalTrials |
Liposarcoma | 2 | D008080 | ClinicalTrials |
Melanoma | 2 | D008545 | ClinicalTrials |
Thymoma | 2 | D013945 | ClinicalTrials |
Carcinoma, Squamous Cell | 2 | D002294 | ClinicalTrials |
Leukemia, Myeloid, Acute | 2 | D015470 | ClinicalTrials |
Small Cell Lung Carcinoma | 2 | D055752 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Lymphoma, Follicular | 2 | D008224 | ClinicalTrials |
Prostatic Neoplasms, Castration-Resistant | 2 | D064129 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Melanoma | 2 | D008545 | ClinicalTrials |
Myelodysplastic Syndromes | 2 | D009190 | ClinicalTrials |
Leukemia, Biphenotypic, Acute | 1 | D015456 | ClinicalTrials |
Diabetic Foot | 1 | D017719 | ClinicalTrials |
Lymphoma, T-Cell, Peripheral | 1 | D016411 | ClinicalTrials |
Hematologic Neoplasms | 1 | D019337 | ClinicalTrials |
Carcinoma, Non-Small-Cell Lung | 1 | D002289 | ClinicalTrials |
Colorectal Neoplasms | 1 | D015179 | ClinicalTrials |
Rectal Neoplasms | 1 | D012004 | ClinicalTrials |
Sarcoma | 1 | D012509 | ClinicalTrials |
Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1 | D054198 | ClinicalTrials |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 1 | D015464 | ClinicalTrials |
Gliosarcoma | 1 | D018316 | ClinicalTrials |
Carcinoma, Renal Cell | 1 | D002292 | ClinicalTrials |
Sarcoma | 1 | D012509 | ClinicalTrials |
Ovarian Neoplasms | 1 | D010051 | ClinicalTrials |
Fallopian Tube Neoplasms | 1 | D005185 | ClinicalTrials |
Urinary Bladder Neoplasms | 1 | D001749 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 1393477-72-9 |
ChEMBL | CHEMBL3545185 |
DrugBank | DB11942 |
DrugCentral | 5330 |
FDA SRS | 31TZ62FO8F |
Guide to Pharmacology | 10036 |
PubChem | 71481097 |
SureChEMBL | SCHEMBL14678327 |
ZINC | ZINC000096170454 |