SEMAGLUTIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2017)
Entry Type: Protein
Molecule Category: UNKNOWN
ATC: A10BJ06
UNII: 53AXN4NNHX

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucagon-like peptide 1 receptor agonist PubMed PubMed
Primary Target
GLP-1 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Glucagon-like receptor Glucagon-like peptide receptor
0 0-357 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Non-alcoholic Fatty Liver Disease 3 D065626 ClinicalTrials
Alzheimer Disease 3 D000544 ClinicalTrials
Non-alcoholic Fatty Liver Disease 3 D065626 ClinicalTrials
Obesity 3 D009765 ClinicalTrials
Depressive Disorder, Major 2 D003865 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Parkinson Disease 2 D010300 ClinicalTrials
Bone Diseases, Metabolic 1 D001851 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
29.88
Injury, poisoning and procedural complications
14.47
Investigations
8.7
General disorders and administration site conditions
8.32
Nervous system disorders
5.75
Metabolism and nutrition disorders
4.69
Vascular disorders
3.31
Cardiac disorders
3.15
Skin and subcutaneous tissue disorders
2.82
Psychiatric disorders
2.27
Eye disorders
2.17
Respiratory, thoracic and mediastinal disorders
2.13
Musculoskeletal and connective tissue disorders
2.09

Cross References

Resources Reference
CAS NUMBER 910463-68-2
ChEMBL CHEMBL2108724
FDA SRS 53AXN4NNHX
Guide to Pharmacology 9724
PubChem 56843331
CONTENTS