SULFADIAZINE

Search structure
Trade Names:
Synonyms:
SSD
Status: Approved (1941)
Entry Type: Small molecule
Molecule Category: Parent
ATC: J01EC02
UNII: 0N7609K889

Structure
InChI Key SEEPANYCNGTZFQ-UHFFFAOYSA-N
Smile Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1
InChI
InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H10N4O2S
Molecular Weight 250.28
AlogP 0.86
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 97.97
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial dihydropteroate synthase inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9
- - - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family
- 21000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 74

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Toxoplasmosis, Congenital 3 D014125 ClinicalTrials
Chorioretinitis 3 D002825 ClinicalTrials
Toxoplasmosis, Cerebral 2 D016781 ClinicalTrials
Burns 2 D002056 ClinicalTrials
Osteomyelitis 0 D010019 ClinicalTrials

Related Entries

MCS

Scaffolds

Salt
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Immune system disorders
16.94
Blood and lymphatic system disorders
11.29
General disorders and administration site conditions
11.29
Gastrointestinal disorders
10.48
Skin and subcutaneous tissue disorders
8.06
Hepatobiliary disorders
6.45
Investigations
6.45
Renal and urinary disorders
6.45
Metabolism and nutrition disorders
5.65
Vascular disorders
4.03
Infections and infestations
2.42
Nervous system disorders
2.42

Cross References

Resources Reference
CAS NUMBER 68-35-9
ChEBI 9328
ChEMBL CHEMBL439
DrugBank DB00359
DrugCentral 2500
EPA CompTox DTXSID7044130
FDA SRS 0N7609K889
Human Metabolome Database HMDB0014503
KEGG C07658
PharmGKB PA451539
PubChem 5215
SureChEMBL SCHEMBL24176
ZINC ZINC000000120319
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