TAVABOROLE

Search structure
Trade Names:
Synonyms:
Status: Approved (2014)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: D01AE24
UNII: K124A4EUQ3

Structure
InChI Key LFQDNHWZDQTITF-UHFFFAOYSA-N
Smile OB1OCc2cc(F)ccc21
InChI
InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H6BFO2
Molecular Weight 151.93
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Leucine-tRNA ligase inhibitor FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Ligase
- 2100 20800 1850-31400 -
Enzyme Lyase
- - - 462-462 -
Enzyme
- 2100 20800 1850-31400 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
29.68
General disorders and administration site conditions
26.85
Injury, poisoning and procedural complications
21.97
Nervous system disorders
3.24
Infections and infestations
3.04
Immune system disorders
2.68

Cross References

Resources Reference
CAS NUMBER 174671-46-6
ChEBI 77942
ChEMBL CHEMBL443052
DrugBank DB09041
DrugCentral 4877
EPA CompTox DTXSID00169888
FDA SRS K124A4EUQ3
KEGG D10169
PubChem 11499245
SureChEMBL SCHEMBL500016
ZINC ZINC000169990691
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