Structure

InChI Key BPEGJWRSRHCHSN-UHFFFAOYSA-N
Smile Cn1nnc2c(C(N)=O)ncn2c1=O
InChI
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

Physicochemical Descriptors

Property Name Value
Molecular Formula C6H6N6O2
Molecular Weight 194.15
AlogP -2.08
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 108.17
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Glioblastoma 4 D005909 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Sarcoma, Ewing 3 D012512 ClinicalTrials
Astrocytoma 3 D001254 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Gliosarcoma 3 D018316 ClinicalTrials
Oligodendroglioma 3 D009837 ClinicalTrials
Oligodendroglioma 3 D009837 ClinicalTrials
Astrocytoma 3 D001254 ClinicalTrials
Oligodendroglioma 3 D009837 ClinicalTrials
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Optic Nerve Glioma 3 D020339 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 3 D000080443 ClinicalTrials
Central Nervous System Neoplasms 3 D016543 ClinicalTrials
Choroid Plexus Neoplasms 3 D016545 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Neoplasm Metastasis 3 D009362 ClinicalTrials
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Rhabdomyosarcoma, Alveolar 2 D018232 ClinicalTrials
Rhabdomyosarcoma, Embryonal 2 D018233 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Brain Diseases 2 D001927 ClinicalTrials
Retinoblastoma 2 D012175 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Neuroectodermal Tumors, Primitive, Peripheral 2 D018241 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Rhabdomyosarcoma 2 D012208 ClinicalTrials
Spinal Cord Neoplasms 2 D013120 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Pinealoma 2 D010871 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Hereditary Breast and Ovarian Cancer Syndrome 2 D061325 ClinicalTrials
Neurofibromatosis 1 2 D009456 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Ganglioneuroblastoma 2 D018305 ClinicalTrials
Carcinoma, Islet Cell 2 D018273 ClinicalTrials
Skin Neoplasms 2 D012878 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Pituitary Neoplasms 2 D010911 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Neuroblastoma 2 D009447 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Medulloblastoma 2 D008527 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Brain Stem Neoplasms 2 D020295 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Cytomegalovirus Infections 1 D003586 ClinicalTrials
Ependymoma 1 D004806 ClinicalTrials
Prostatic Neoplasms 1 D011471 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 1 D064129 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Meningitis, Aseptic 1 D008582 ClinicalTrials
Desmoplastic Small Round Cell Tumor 0 D058405 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Skin and subcutaneous tissue disorders Alopecia 69.1
Skin and subcutaneous tissue disorders Alopecia 69.0
Skin and subcutaneous tissue disorders Alopecia 63.0
Skin and subcutaneous tissue disorders Alopecia 62.8
General disorders and administration site conditions Asthenia 61.2
General disorders and administration site conditions Fatigue 61.2
General disorders and administration site conditions Asthenia 61.0
General disorders and administration site conditions Fatigue 61.0
Skin and subcutaneous tissue disorders Alopecia 55.4
Skin and subcutaneous tissue disorders Alopecia 55.0
General disorders and administration site conditions Asthenia 54.2
General disorders and administration site conditions Fatigue 54.2
General disorders and administration site conditions Asthenia 54.0
General disorders and administration site conditions Fatigue 54.0
Gastrointestinal disorders Nausea 53.2
Gastrointestinal disorders Nausea 49.1
General disorders and administration site conditions Asthenia 49.0
General disorders and administration site conditions Fatigue 49.0
Gastrointestinal disorders Nausea 49.0
General disorders and administration site conditions Asthenia 48.8
General disorders and administration site conditions Fatigue 48.8
Gastrointestinal disorders Nausea 43.0
Gastrointestinal disorders Nausea 42.0
Gastrointestinal disorders Vomiting 41.8
Nervous system disorders Headache 41.1
Gastrointestinal disorders Nausea 41.0
Gastrointestinal disorders Nausea 36.5
Gastrointestinal disorders Nausea 36.0
Gastrointestinal disorders Vomiting 36.0
Gastrointestinal disorders Vomiting 35.0
General disorders and administration site conditions Asthenia 34.2
General disorders and administration site conditions Fatigue 34.2
Gastrointestinal disorders Vomiting 34.0
Gastrointestinal disorders Constipation 32.9
Gastrointestinal disorders Vomiting 29.5
Gastrointestinal disorders Vomiting 29.0
General disorders and administration site conditions Decreased appetite 27.2
General disorders and administration site conditions Decreased appetite 27.0
General disorders and administration site conditions Asthenia 23.0
General disorders and administration site conditions Fatigue 23.0
Nervous system disorders Headache 23.0
Convulsion 22.8
Nervous system disorders Headache 22.8
General disorders and administration site conditions Asthenia 22.0
Gastrointestinal disorders Constipation 22.0
General disorders and administration site conditions Fatigue 22.0
Gastrointestinal disorders Constipation 21.9
Gastrointestinal disorders Vomiting 20.0
Gastrointestinal disorders Vomiting 19.8
General disorders and administration site conditions Decreased appetite 19.4
Skin and subcutaneous tissue disorders Dermatitis 19.4
Nervous system disorders Headache 19.4
Skin and subcutaneous tissue disorders Rash 19.4
General disorders and administration site conditions Decreased appetite 19.0
Skin and subcutaneous tissue disorders Dermatitis 19.0
Nervous system disorders Headache 19.0
Skin and subcutaneous tissue disorders Rash 19.0
Gastrointestinal disorders Constipation 18.4
Nervous system disorders Hemiparesis 18.4
Gastrointestinal disorders Constipation 18.0
Nervous system disorders Headache 17.2
Gastrointestinal disorders Constipation 17.0
Nervous system disorders Headache 17.0
Gastrointestinal disorders Nausea 16.0
Gastrointestinal disorders Diarrhoea 15.8
Gastrointestinal disorders Nausea 15.8
Gastrointestinal disorders Constipation 15.0
Skin and subcutaneous tissue disorders Dermatitis 15.0
Skin and subcutaneous tissue disorders Rash 15.0
Skin and subcutaneous tissue disorders Dermatitis 14.7
Skin and subcutaneous tissue disorders Rash 14.7
Nervous system disorders Headache 14.0
Investigations Body temperature increased 13.3
General disorders and administration site conditions Asthenia 13.0
Skin and subcutaneous tissue disorders Dermatitis 13.0
General disorders and administration site conditions Fatigue 13.0
Skin and subcutaneous tissue disorders Rash 13.0
Skin and subcutaneous tissue disorders Dermatitis 12.9
Skin and subcutaneous tissue disorders Rash 12.9
General disorders and administration site conditions Asthenia 12.7
Cardiac disorders Dizziness 12.0
Convulsion 11.2
General disorders and administration site conditions Decreased appetite 11.0
Nervous system disorders Headache 11.0
Nervous system disorders Coordination abnormal 10.8
Cardiac disorders Oedema peripheral 10.8
Infections and infestations Viral infection 10.8
Gastrointestinal disorders Diarrhoea 10.3
Nervous system disorders Amnesia 10.1
Nervous system disorders Insomnia 10.1
Gastrointestinal disorders Nausea 10.1
Gastrointestinal disorders Diarrhoea 10.0
Nervous system disorders Paraesthesia 9.49
Nervous system disorders Somnolence 9.49
Eye disorders Vision blurred 9.03
Blood and lymphatic system disorders Coagulopathy 9.0
General disorders and administration site conditions Decreased appetite 9.0
Investigations Haemoglobin 9.0
Vascular disorders Haemorrhage 9.0
Psychiatric disorders Mental disorder 9.0
Gastrointestinal disorders Stomatitis 9.0
Blood and lymphatic system disorders Thrombocytopenia 9.0
General disorders and administration site conditions Asthenia 8.93
General disorders and administration site conditions Fatigue 8.93
Gastrointestinal disorders Stomatitis 8.93
Gastrointestinal disorders Abdominal pain 8.86
General disorders and administration site conditions Decreased appetite 8.86
Gastrointestinal disorders Gastrointestinal pain 8.86
General disorders and administration site conditions Decreased appetite 8.77
Eye disorders Vision blurred 8.77
Respiratory, thoracic and mediastinal disorders Cough 8.48
Blood and lymphatic system disorders Thrombocytopenia 8.48
Skin and subcutaneous tissue disorders Dermatitis 8.23
Endocrine disorders Hyperadrenocorticism 8.23
Nervous system disorders Paresis 8.23
Skin and subcutaneous tissue disorders Rash 8.23
Infections and infestations Upper respiratory tract infection 8.23
Nervous system disorders Urinary incontinence 8.23
Respiratory, thoracic and mediastinal disorders Cough 8.0
Gastrointestinal disorders Diarrhoea 8.0
Blood and lymphatic system disorders Thrombocytopenia 8.0
Nervous system disorders Ataxia 7.59
Musculoskeletal and connective tissue disorders Back pain 7.59
Gastrointestinal disorders Pharyngitis 7.59
Skin and subcutaneous tissue disorders Pruritus 7.59
Infections and infestations Urinary tract infection 7.59
Eye disorders Vision blurred 7.59
General disorders and administration site conditions Asthenia 7.14
Nervous system disorders Memory impairment 7.14
Convulsion 7.02
Gastrointestinal disorders Diarrhoea 7.0
Injury, poisoning and procedural complications Radiation injury 7.0
Gastrointestinal disorders Stomatitis 7.0
Psychiatric disorders Anxiety 6.96
Nervous system disorders Aphasia 6.96
Injury, poisoning and procedural complications Radiation injury 6.94
General disorders and administration site conditions Asthenia 6.6
General disorders and administration site conditions Fatigue 6.6
Gastrointestinal disorders Stomatitis 6.6
Psychiatric disorders Depression 6.33
Nervous system disorders Headache 6.33
Nervous system disorders Hemiparesis 6.33
Infections and infestations Sinusitis 6.33
Gastrointestinal disorders Vomiting 6.33
Gastrointestinal disorders Constipation 6.32
Musculoskeletal and connective tissue disorders Arthralgia 6.25
Gastrointestinal disorders Diarrhoea 6.25
Gastrointestinal disorders Dysgeusia 6.25
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.25
Musculoskeletal and connective tissue disorders Arthralgia 6.0
Gastrointestinal disorders Constipation 6.0
Convulsion 6.0
Gastrointestinal disorders Diarrhoea 6.0
Gastrointestinal disorders Dysgeusia 6.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.0
Gastrointestinal disorders Vomiting 6.0
Convulsion 5.9
General disorders and administration site conditions Asthenia 5.7
General disorders and administration site conditions Gait disturbance 5.7
Nervous system disorders Partial seizures 5.7
Gastrointestinal disorders Vomiting 5.61
Nervous system disorders Confusional state 5.36
Cardiac disorders Dizziness 5.36
Cardiac disorders Dyspnoea 5.36
General disorders and administration site conditions Feeling abnormal 5.36
General disorders and administration site conditions Asthenia 5.26
Skin and subcutaneous tissue disorders Erythema 5.26
General disorders and administration site conditions Fatigue 5.26
Respiratory, thoracic and mediastinal disorders Cough 5.21
Nervous system disorders Confusional state 5.06
Convulsion 5.06
Respiratory, thoracic and mediastinal disorders Cough 5.06
Eye disorders Diplopia 5.06
General disorders and administration site conditions Feeling abnormal 5.06
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.06
Musculoskeletal and connective tissue disorders Myalgia 5.06
Eye disorders Visual impairment 5.06
Investigations Weight increased 5.06
Gastrointestinal disorders Abdominal pain 5.0
General disorders and administration site conditions Asthenia 5.0
Respiratory, thoracic and mediastinal disorders Cough 5.0
Skin and subcutaneous tissue disorders Dermatitis 5.0
Gastrointestinal disorders Dysgeusia 5.0
Cardiac disorders Dyspnoea 5.0
Gastrointestinal disorders Gastrointestinal pain 5.0
Nervous system disorders Headache 5.0
Immune system disorders Hypersensitivity 5.0
Nervous system disorders Insomnia 5.0
Gastrointestinal disorders Nausea 5.0
Skin and subcutaneous tissue disorders Pruritus 5.0
Skin and subcutaneous tissue disorders Rash 5.0
Gastrointestinal disorders Stomatitis 5.0
Blood and lymphatic system disorders Thrombocytopenia 5.0
Gastrointestinal disorders Abdominal pain 4.91
Skin and subcutaneous tissue disorders Dry skin 4.91
Gastrointestinal disorders Dysgeusia 4.91
Gastrointestinal disorders Gastrointestinal pain 4.91
Skin and subcutaneous tissue disorders Pruritus 4.91
Gastrointestinal disorders Stomatitis 4.91
Skin and subcutaneous tissue disorders Erythema 4.86
Nervous system disorders Insomnia 4.86
Immune system disorders Hypersensitivity 4.51
General disorders and administration site conditions Asthenia 4.43
General disorders and administration site conditions Fatigue 4.43
Nervous system disorders Confusional state 4.21
General disorders and administration site conditions Feeling abnormal 4.21
Nervous system disorders Memory impairment 4.21
Cardiac disorders Dizziness 4.17
Nervous system disorders Headache 4.02
Nervous system disorders Insomnia 4.02
Investigations Alanine aminotransferase increased 4.0
Skin and subcutaneous tissue disorders Alopecia 4.0
Investigations Body temperature increased 4.0
Blood and lymphatic system disorders Coagulopathy 4.0
Ear and labyrinth disorders Deafness 4.0
Cardiac disorders Dyspnoea 4.0
Hearing impaired 4.0
Nervous system disorders Insomnia 4.0
Blood and lymphatic system disorders Leukopenia 4.0
Blood and lymphatic system disorders Neutropenia 4.0
Vascular disorders Petechiae 4.0
Skin and subcutaneous tissue disorders Pruritus 4.0
Injury, poisoning and procedural complications Radiation injury 4.0
Nervous system disorders Somnolence 4.0
Blood and lymphatic system disorders Thrombocytopenia 4.0
Gastrointestinal disorders Vomiting 4.0
Nervous system disorders Headache 3.86
Injury, poisoning and procedural complications Radiation injury 3.86
Nervous system disorders Confusional state 3.82
Cardiac disorders Dyspnoea 3.82
General disorders and administration site conditions Feeling abnormal 3.82
Skin and subcutaneous tissue disorders Pruritus 3.82
Blood and lymphatic system disorders Thrombocytopenia 3.82
Nervous system disorders Amnesia 3.8
Reproductive system and breast disorders Breast pain 3.8
Blood and lymphatic system disorders Thrombocytopenia 3.57
Cardiac disorders Dizziness 3.51
General disorders and administration site conditions Asthenia 3.47
Convulsion 3.47
General disorders and administration site conditions Asthenia 3.16
Convulsion 3.16
Gastrointestinal disorders Diarrhoea 3.16
Cardiac disorders Dyspnoea 3.16
Nervous system disorders Insomnia 3.16
Nervous system disorders Somnolence 3.16
Convulsion 3.12
Gastrointestinal disorders Abdominal pain 3.0
Nervous system disorders Aphasia 3.0
Convulsion 3.0
Ear and labyrinth disorders Deafness 3.0
Gastrointestinal disorders Diarrhoea 3.0
Nervous system disorders Disturbance in attention 3.0
Gastrointestinal disorders Dyspepsia 3.0
Gastrointestinal disorders Dysphagia 3.0
Cardiac disorders Dyspnoea 3.0
General disorders and administration site conditions Face oedema 3.0
Gastrointestinal disorders Gastrointestinal pain 3.0
Investigations Haemoglobin 3.0
Vascular disorders Haemorrhage 3.0
Hearing impaired 3.0
Immune system disorders Hypersensitivity 3.0
Nervous system disorders Insomnia 3.0
Blood and lymphatic system disorders Leukopenia 3.0
Social circumstances Mental disability 3.0
Nervous system disorders Muscular weakness 3.0
Nervous system disorders Neuropathy peripheral 3.0
Blood and lymphatic system disorders Neutropenia 3.0
General disorders and administration site conditions Pain 3.0
Skin and subcutaneous tissue disorders Pruritus 3.0
Investigations Weight decreased 3.0
Nervous system disorders Memory impairment 2.78
Blood and lymphatic system disorders Thrombocytopenia 2.78
Immune system disorders Hypersensitivity 2.68
Musculoskeletal and connective tissue disorders Back pain 2.53
Nervous system disorders Paresis 2.53
Immune system disorders Hypersensitivity 2.46
Gastrointestinal disorders Abdominal pain 2.43
Musculoskeletal and connective tissue disorders Arthralgia 2.43
Skin and subcutaneous tissue disorders Dry skin 2.43
Gastrointestinal disorders Gastrointestinal pain 2.43
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.43
Injury, poisoning and procedural complications Radiation injury 2.23
Nervous system disorders Confusional state 2.11
Skin and subcutaneous tissue disorders Dry skin 2.11
Gastrointestinal disorders Dysgeusia 2.11
General disorders and administration site conditions Feeling abnormal 2.11
Gastrointestinal disorders Abdominal pain 2.0
Investigations Alanine aminotransferase increased 2.0
Blood and lymphatic system disorders Anaemia 2.0
Nervous system disorders Aphasia 2.0
Musculoskeletal and connective tissue disorders Arthralgia 2.0
General disorders and administration site conditions Asthenia 2.0
Infections and infestations Candida infection 2.0
General disorders and administration site conditions Discomfort 2.0
Nervous system disorders Disturbance in attention 2.0
Cardiac disorders Dizziness 2.0
Gastrointestinal disorders Dysgeusia 2.0
Gastrointestinal disorders Dyspepsia 2.0
Gastrointestinal disorders Dysphagia 2.0
Cardiac disorders Dyspnoea 2.0
General disorders and administration site conditions Fatigue 2.0
General disorders and administration site conditions Feeling abnormal 2.0
Gastrointestinal disorders Gastrointestinal pain 2.0
Investigations Haemoglobin 2.0
Vascular disorders Haemorrhage 2.0
Nervous system disorders Headache 2.0
Endocrine disorders Hyperglycaemia 2.0
Immune system disorders Hypersensitivity 2.0
General disorders and administration site conditions Ill-defined disorder 2.0
Nervous system disorders Insomnia 2.0
Blood and lymphatic system disorders Leukopenia 2.0
Blood and lymphatic system disorders Lymphopenia 2.0
General disorders and administration site conditions Malaise 2.0
Social circumstances Mental disability 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Nervous system disorders Neuropathy peripheral 2.0
Blood and lymphatic system disorders Neutropenia 2.0
Cardiac disorders Oedema peripheral 2.0
Gastrointestinal disorders Oral candidiasis 2.0
General disorders and administration site conditions Pain 2.0
Nervous system disorders Paraesthesia 2.0
Renal and urinary disorders Pollakiuria 2.0
Injury, poisoning and procedural complications Radiation injury 2.0
Nervous system disorders Somnolence 2.0
Nervous system disorders Urinary incontinence 2.0
Investigations Weight decreased 2.0
Nervous system disorders Ataxia 1.9
Investigations Body temperature increased 1.9
Gastrointestinal disorders Diarrhoea 1.9
Nervous system disorders Urinary incontinence 1.9
General disorders and administration site conditions Asthenia 1.79
Nervous system disorders Confusional state 1.79
General disorders and administration site conditions Feeling abnormal 1.79
Gastrointestinal disorders Vomiting 1.79
General disorders and administration site conditions Asthenia 1.74
Cardiac disorders Dyspnoea 1.74
Nervous system disorders Headache 1.74
Cardiac disorders Dyspnoea 1.4
Skin and subcutaneous tissue disorders Pruritus 1.4
Eye disorders Vision blurred 1.4
Nervous system disorders Confusional state 1.39
General disorders and administration site conditions Feeling abnormal 1.39
General disorders and administration site conditions Decreased appetite 1.34
Skin and subcutaneous tissue disorders Dermatitis 1.34
Gastrointestinal disorders Nausea 1.34
Skin and subcutaneous tissue disorders Rash 1.34
Gastrointestinal disorders Stomatitis 1.34
Gastrointestinal disorders Abdominal pain 1.27
Nervous system disorders Coordination abnormal 1.27
Gastrointestinal disorders Gastrointestinal pain 1.27
Skin and subcutaneous tissue disorders Pruritus 1.27
General disorders and administration site conditions Asthenia 1.05
Respiratory, thoracic and mediastinal disorders Cough 1.05
Blood and lymphatic system disorders Thrombocytopenia 1.05
Gastrointestinal disorders Constipation 1.04
Skin and subcutaneous tissue disorders Dermatitis 1.04
Skin and subcutaneous tissue disorders Rash 1.04
Gastrointestinal disorders Abdominal pain 1.0
Nervous system disorders Altered state of consciousness 1.0
Blood and lymphatic system disorders Anaemia 1.0
Nervous system disorders Aphasia 1.0
Musculoskeletal and connective tissue disorders Arthralgia 1.0
Investigations Body temperature increased 1.0
General disorders and administration site conditions Chills 1.0
Nervous system disorders Confusional state 1.0
Gastrointestinal disorders Constipation 1.0
Convulsion 1.0
Respiratory, thoracic and mediastinal disorders Cough 1.0
Ear and labyrinth disorders Deafness 1.0
Metabolism and nutrition disorders Dehydration 1.0
Nervous system disorders Depressed level of consciousness 1.0
Psychiatric disorders Depression 1.0
Gastrointestinal disorders Diarrhoea 1.0
Nervous system disorders Disturbance in attention 1.0
Gastrointestinal disorders Dysgeusia 1.0
Gastrointestinal disorders Dysphagia 1.0
General disorders and administration site conditions Face oedema 1.0
General disorders and administration site conditions Feeling abnormal 1.0
Gastrointestinal disorders Gastrointestinal pain 1.0
Investigations Haemoglobin 1.0
Vascular disorders Haemorrhage 1.0
Nervous system disorders Haemorrhage intracranial 1.0
Hearing impaired 1.0
Nervous system disorders Hemiparesis 1.0
Endocrine disorders Hyperglycaemia 1.0
Lung infection 1.0
Blood and lymphatic system disorders Lymphopenia 1.0
Social circumstances Mental disability 1.0
Psychiatric disorders Mental disorder 1.0
Nervous system disorders Muscular weakness 1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.0
Musculoskeletal and connective tissue disorders Myalgia 1.0
Cardiac disorders Oedema peripheral 1.0
General disorders and administration site conditions Pain 1.0
Blood and lymphatic system disorders Pancytopenia 1.0
Nervous system disorders Paraesthesia 1.0
Nervous system disorders Paresis 1.0
Infections and infestations Pneumonia 1.0
Renal and urinary disorders Pollakiuria 1.0
Skin and subcutaneous tissue disorders Pruritus 1.0
Respiratory, thoracic and mediastinal disorders Pulmonary embolism 1.0
Blood and lymphatic system disorders Purpura 1.0
Nervous system disorders Somnolence 1.0
Blood and lymphatic system disorders Thrombocytopenia 1.0
Nervous system disorders Transient ischaemic attack 1.0
Nervous system disorders Urinary incontinence 1.0
Blood and lymphatic system disorders Vascular purpura 1.0
Investigations Weight decreased 1.0
Gastrointestinal disorders Diarrhoea 0.893
Skin and subcutaneous tissue disorders Erythema 0.893
Nervous system disorders Memory impairment 0.893
Gastrointestinal disorders Abdominal pain 0.702
Musculoskeletal and connective tissue disorders Arthralgia 0.702
Gastrointestinal disorders Gastrointestinal pain 0.702
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.702
Respiratory, thoracic and mediastinal disorders Cough 0.694
General disorders and administration site conditions Decreased appetite 0.694
Cardiac disorders Dizziness 0.694
Gastrointestinal disorders Nausea 0.694
Eye disorders Vision blurred 0.694
Psychiatric disorders Anxiety 0.633
Nervous system disorders Aphasia 0.633
Gastrointestinal disorders Constipation 0.633
General disorders and administration site conditions Decreased appetite 0.633
Cardiac disorders Dizziness 0.633
General disorders and administration site conditions Gait disturbance 0.633
Cardiac disorders Oedema peripheral 0.633
Nervous system disorders Paraesthesia 0.633
Gastrointestinal disorders Abdominal pain 0.446
Respiratory, thoracic and mediastinal disorders Cough 0.446
Skin and subcutaneous tissue disorders Dry skin 0.446
Cardiac disorders Dyspnoea 0.446
Gastrointestinal disorders Gastrointestinal pain 0.446
General disorders and administration site conditions Decreased appetite 0.351
Immune system disorders Hypersensitivity 0.351
Nervous system disorders Insomnia 0.351
Nervous system disorders Memory impairment 0.351
Gastrointestinal disorders Nausea 0.351
Injury, poisoning and procedural complications Radiation injury 0.351
Gastrointestinal disorders Stomatitis 0.351
Gastrointestinal disorders Vomiting 0.351
Gastrointestinal disorders Abdominal pain 0.347
Musculoskeletal and connective tissue disorders Arthralgia 0.347
Gastrointestinal disorders Gastrointestinal pain 0.347
Nervous system disorders Memory impairment 0.347
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.347
Gastrointestinal disorders Vomiting 0.347

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
Investigations
14.33
General disorders and administration site conditions
11.42
Nervous system disorders
10.23
Gastrointestinal disorders
8.16
Metabolism and nutrition disorders
7.88
Infections and infestations
7.44
Blood and lymphatic system disorders
6.4
Injury, poisoning and procedural complications
5.15
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
3.73
Skin and subcutaneous tissue disorders
3.64
Respiratory, thoracic and mediastinal disorders
3.36
Vascular disorders
3.24
Psychiatric disorders
2.77
Hepatobiliary disorders
2.73
Renal and urinary disorders
2.18

Cross References

Resources Reference
CAS NUMBER 85622-93-1
ChEBI 72564
ChEMBL CHEMBL810
DrugBank DB00853
DrugCentral 2589
EPA CompTox DTXSID5043714
FDA SRS YF1K15M17Y
Human Metabolome Database HMDB0014991
Guide to Pharmacology 7301
KEGG D06067
PharmGKB PA451609
PubChem 5394
SureChEMBL SCHEMBL3739
ZINC ZINC000001482184