THIOPENTAL SODIUM

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Trade Names:	PENTOTHAL
Synonyms:	Farmotal Hypnostan Intraval Intraval sod Leopental Nesdonal NSC-759557 Penthiobarbital Penthiobarbital sodium Pentothal Ravonal Sodium pentothal Sodium thiopental Thiomebumal Thiomebumal sodium Thionembutal Thiopental sodium Thiopental Sodium Thiopentalum natricum Thiopentobarbitone sodium Thiopentone Thiopentone sodium Trapanal
Status:	Approved (1982)
Entry Type:	Small molecule
Molecule Category:	Salt
UNII:	49Y44QZL70
Parent Compound:	THIOPENTAL

Structure


InChI Key	AWLILQARPMWUHA-UHFFFAOYSA-M
Smile	CCCC(C)C1(CC)C(=O)N=C([S-])NC1=O.[Na+]
InChI	InChI=1S/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C11H17N2NaO2S
Molecular Weight	264.33
AlogP	1.35
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	58.2
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	16.0

Pharmacology

Action	Mechanism of Action	Reference
POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	ISBN PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	73

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Amnesia	1	D000647	ClinicalTrials

Related Entries

Parent

Cross References

Resources	Reference
ChEBI	9561
ChEMBL	CHEMBL738
EPA CompTox	DTXSID1021744
FDA SRS	49Y44QZL70
PubChem	12832575
SureChEMBL	SCHEMBL34621

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