TOLAZAMIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1966)
Entry Type: Small molecule
Molecule Category: Parent
ATC: A10BB05
UNII: 9LT1BRO48Q

Structure
InChI Key OUDSBRTVNLOZBN-UHFFFAOYSA-N
Smile Cc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1
InChI
InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H21N3O3S
Molecular Weight 311.41
AlogP 1.77
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 78.51
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Sulfonylurea receptor 1, Kir6.2 blocker
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 5.745
Enzyme Oxidoreductase
- 5106 - - -
Enzyme Transferase
- - - - 32.71
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -37.85--0.79
Secreted protein
- - - 53703179637025.33 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 109.61
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 285700 - - -

Metabolites

visNetwork

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

MCS

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Renal and urinary disorders
100.0

Cross References

Resources Reference
CAS NUMBER 1156-19-0
ChEBI 9613
ChEMBL CHEMBL817
DrugBank DB00839
DrugCentral 2694
EPA CompTox DTXSID3021358
FDA SRS 9LT1BRO48Q
Human Metabolome Database HMDB14977
Guide to Pharmacology 6847
PharmGKB PA164774902
PubChem 5503
SureChEMBL SCHEMBL34417
ZINC ZINC000000057512
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