TOPOTECAN HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1996)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 956S425ZCY
Parent Compound: TOPOTECAN

Structure
InChI Key DGHHQBMTXTWTJV-BQAIUKQQSA-N
Smile CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1.Cl
InChI
InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H24ClN3O5
Molecular Weight 457.91
AlogP 1.85
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 104.89
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA topoisomerase I, mitochondrial inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Isomerase
- 1080 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Small Cell 4 D018288 ClinicalTrials
Ovarian Neoplasms 4 D010051 ClinicalTrials
Ovarian Neoplasms 4 D010051 ClinicalTrials
Ovarian Neoplasms 4 D010051 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Neoplasms 3 D009369 ClinicalTrials
Neuroblastoma 3 D009447 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Mesenchymoma 3 D008637 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 D054198 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Retinoblastoma 3 D012175 ClinicalTrials
Rhabdomyosarcoma 3 D012208 ClinicalTrials
Neoplasms 3 D009369 ClinicalTrials
Wilms Tumor 2 D009396 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Sarcoma, Ewing 2 D012512 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Mediastinal Neoplasms 2 D008479 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Wilms Tumor 2 D009396 ClinicalTrials
Ganglioneuroblastoma 2 D018305 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Neuroectodermal Tumors, Primitive, Peripheral 2 D018241 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Astrocytoma 1 D001254 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Oligodendroglioma 1 D009837 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Glioblastoma 1 D005909 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Carcinoma, Endometrioid 1 D018269 ClinicalTrials
Genital Neoplasms, Female 1 D005833 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Myeloproliferative Disorders 1 D009196 ClinicalTrials
Cystadenoma, Serous 1 D018293 ClinicalTrials
Rectal Neoplasms 1 D012004 ClinicalTrials
Meningitis, Aseptic 1 D008582 ClinicalTrials
Meningeal Neoplasms 1 D008577 ClinicalTrials
Oligodendroglioma 1 D009837 ClinicalTrials

Related Entries

Scaffolds

Parent

Side Effects from Label

Side effects Relative Frequency (%) Labels
Blood and lymphatic system disorders Anaemia 98.0
Blood and lymphatic system disorders Leukopenia 97.0
Blood and lymphatic system disorders Neutropenia 97.0
Blood and lymphatic system disorders Anaemia 94.0
Blood and lymphatic system disorders Leukopenia 91.0
Blood and lymphatic system disorders Neutropenia 91.0
Blood and lymphatic system disorders Anaemia 89.0
Blood and lymphatic system disorders Neutropenia 89.0
Blood and lymphatic system disorders Neutropenia 83.0
Blood and lymphatic system disorders Thrombocytopenia 81.0
Blood and lymphatic system disorders Neutropenia 80.2
Blood and lymphatic system disorders Neutropenia 80.0
Blood and lymphatic system disorders Neutropenia 78.0
Blood and lymphatic system disorders Thrombocytopenia 74.0
Blood and lymphatic system disorders Neutropenia 72.0
Blood and lymphatic system disorders Neutropenia 70.0
Blood and lymphatic system disorders Thrombocytopenia 69.0
Gastrointestinal disorders Nausea 64.0
Gastrointestinal disorders Nausea 56.0
Gastrointestinal disorders Nausea 55.0
Gastrointestinal disorders Nausea 54.9
Skin and subcutaneous tissue disorders Alopecia 54.0
Gastrointestinal disorders Nausea 52.0
Blood and lymphatic system disorders Neutropenia 51.0
General disorders and administration site conditions Pain 50.0
Skin and subcutaneous tissue disorders Alopecia 49.0
Gastrointestinal disorders Vomiting 45.0
Investigations Body temperature increased 43.0
Infections and infestations Infection 43.0
Infections and infestations Infestation 43.0
Blood and lymphatic system disorders Neutropenia 43.0
Infections and infestations Sepsis 43.0
Blood and lymphatic system disorders Anaemia 42.0
Gastrointestinal disorders Nausea 42.0
Blood and lymphatic system disorders Anaemia 41.4
Blood and lymphatic system disorders Anaemia 41.0
Blood and lymphatic system disorders Neutropenia 39.0
Blood and lymphatic system disorders Neutropenia 38.0
Blood and lymphatic system disorders Anaemia 37.0
Gastrointestinal disorders Vomiting 37.0
Gastrointestinal disorders Vomiting 36.8
Blood and lymphatic system disorders Neutropenia 36.0
Gastrointestinal disorders Vomiting 36.0
Blood and lymphatic system disorders Neutropenia 35.8
Gastrointestinal disorders Nausea 33.0
Blood and lymphatic system disorders Neutropenia 33.0
Gastrointestinal disorders Diarrhoea 32.0
Blood and lymphatic system disorders Neutropenia 32.0
Gastrointestinal disorders Vomiting 32.0
Skin and subcutaneous tissue disorders Alopecia 31.0
Nervous system disorders Neuropathy peripheral 30.0
Blood and lymphatic system disorders Thrombocytopenia 30.0
General disorders and administration site conditions Asthenia 29.0
Gastrointestinal disorders Constipation 29.0
General disorders and administration site conditions Fatigue 29.0
Blood and lymphatic system disorders Thrombocytopenia 29.0
Investigations Body temperature increased 28.0
Blood and lymphatic system disorders Febrile neutropenia 28.0
Infections and infestations Infection 28.0
Blood and lymphatic system disorders Neutropenia 28.0
Gastrointestinal disorders Nausea 27.0
Blood and lymphatic system disorders Thrombocytopenia 27.0
Investigations Body temperature increased 26.0
Blood and lymphatic system disorders Neutropenia 26.0
General disorders and administration site conditions Asthenia 25.0
General disorders and administration site conditions Asthenia 24.0
General disorders and administration site conditions Fatigue 24.0
Blood and lymphatic system disorders Neutropenia 24.0
Investigations Body temperature increased 23.2
Blood and lymphatic system disorders Neutropenia 23.2
Investigations Body temperature increased 23.0
Infections and infestations Infection 23.0
Infections and infestations Infestation 23.0
Blood and lymphatic system disorders Neutropenia 23.0
General disorders and administration site conditions Pain 23.0
Infections and infestations Sepsis 23.0
Gastrointestinal disorders Abdominal pain 22.0
General disorders and administration site conditions Asthenia 22.0
Gastrointestinal disorders Diarrhoea 22.0
Cardiac disorders Dyspnoea 22.0
General disorders and administration site conditions Fatigue 22.0
Gastrointestinal disorders Gastrointestinal pain 22.0
Gastrointestinal disorders Vomiting 22.0
Blood and lymphatic system disorders Neutropenia 21.4
Gastrointestinal disorders Diarrhoea 21.0
Blood and lymphatic system disorders Neutropenia 21.0
Gastrointestinal disorders Vomiting 21.0
Skin and subcutaneous tissue disorders Alopecia 20.0
Blood and lymphatic system disorders Anaemia 20.0
General disorders and administration site conditions Pain 20.0
General disorders and administration site conditions Asthenia 19.0
General disorders and administration site conditions Decreased appetite 19.0
General disorders and administration site conditions Fatigue 19.0
Metabolism and nutrition disorders Malnutrition 19.0
Gastrointestinal disorders Vomiting 19.0
Blood and lymphatic system disorders Febrile neutropenia 18.1
Infections and infestations Infection 18.1
Blood and lymphatic system disorders Anaemia 18.0
General disorders and administration site conditions Asthenia 18.0
Investigations Body temperature increased 18.0
Gastrointestinal disorders Diarrhoea 18.0
Blood and lymphatic system disorders Febrile neutropenia 18.0
Nervous system disorders Headache 18.0
Infections and infestations Infection 18.0
Nervous system disorders Nervous system disorder 18.0
Gastrointestinal disorders Stomatitis 18.0
Gastrointestinal disorders Stomatitis 17.0
Blood and lymphatic system disorders Anaemia 16.1
Blood and lymphatic system disorders Anaemia 16.0
Skin and subcutaneous tissue disorders Dermatitis 16.0
General disorders and administration site conditions Pain 16.0
Skin and subcutaneous tissue disorders Rash 16.0
Blood and lymphatic system disorders Anaemia 15.0
Investigations Body temperature increased 15.0
Gastrointestinal disorders Constipation 15.0
Respiratory, thoracic and mediastinal disorders Cough 15.0
Blood and lymphatic system disorders Febrile neutropenia 15.0
Infections and infestations Infection 15.0
General disorders and administration site conditions Decreased appetite 14.0
Gastrointestinal disorders Diarrhoea 14.0
Cardiac disorders Dyspnoea 14.0
Investigations Haemoglobin 14.0
Vascular disorders Haemorrhage 14.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 14.0
General disorders and administration site conditions Mucosal inflammation 14.0
Gastrointestinal disorders Vomiting 14.0
Investigations Haemoglobin 13.9
Vascular disorders Haemorrhage 13.9
General disorders and administration site conditions Asthenia 13.0
Investigations Body temperature increased 13.0
General disorders and administration site conditions Decreased appetite 13.0
Gastrointestinal disorders Nausea 13.0
Blood and lymphatic system disorders Neutropenia 13.0
General disorders and administration site conditions Pain 13.0
General disorders and administration site conditions Pain 12.5
General disorders and administration site conditions Decreased appetite 12.0
General disorders and administration site conditions Asthenia 11.0
Investigations Body temperature increased 11.0
Cardiac disorders Dyspnoea 11.0
General disorders and administration site conditions Fatigue 11.0
General disorders and administration site conditions Pain 11.0
Gastrointestinal disorders Abdominal pain 10.0
Skin and subcutaneous tissue disorders Alopecia 10.0
Blood and lymphatic system disorders Anaemia 10.0
General disorders and administration site conditions Asthenia 10.0
Gastrointestinal disorders Constipation 10.0
General disorders and administration site conditions Fatigue 10.0
Gastrointestinal disorders Gastrointestinal pain 10.0
Gastrointestinal disorders Nausea 10.0
Blood and lymphatic system disorders Thrombocytopenia 10.0
Gastrointestinal disorders Vomiting 10.0
Gastrointestinal disorders Vomiting 9.9
Gastrointestinal disorders Nausea 9.8
Gastrointestinal disorders Nausea 9.03
Gastrointestinal disorders Vomiting 9.03
General disorders and administration site conditions Asthenia 9.0
Investigations Body temperature increased 9.0
Gastrointestinal disorders Constipation 9.0
General disorders and administration site conditions Decreased appetite 9.0
Cardiac disorders Dyspnoea 9.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 9.0
Gastrointestinal disorders Nausea 9.0
Blood and lymphatic system disorders Neutropenia 9.0
Blood and lymphatic system disorders Thrombocytopenia 9.0
Gastrointestinal disorders Vomiting 9.0
Blood and lymphatic system disorders Neutropenia 8.6
Investigations Body temperature increased 8.0
Skin and subcutaneous tissue disorders Dermatitis 8.0
Blood and lymphatic system disorders Febrile neutropenia 8.0
Infections and infestations Infection 8.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 8.0
Gastrointestinal disorders Nausea 8.0
Infections and infestations Pneumonia 8.0
Skin and subcutaneous tissue disorders Rash 8.0
Gastrointestinal disorders Stomatitis 8.0
Blood and lymphatic system disorders Febrile neutropenia 7.64
Infections and infestations Infection 7.64
General disorders and administration site conditions Asthenia 7.1
General disorders and administration site conditions Fatigue 7.1
Blood and lymphatic system disorders Anaemia 7.0
General disorders and administration site conditions Asthenia 7.0
Investigations Body temperature increased 7.0
Respiratory, thoracic and mediastinal disorders Cough 7.0
General disorders and administration site conditions Decreased appetite 7.0
Cardiac disorders Dyspnoea 7.0
General disorders and administration site conditions Fatigue 7.0
Nervous system disorders Headache 7.0
Infections and infestations Infection 7.0
Gastrointestinal disorders Nausea 7.0
Blood and lymphatic system disorders Neutropenia 7.0
General disorders and administration site conditions Pain 7.0
Infections and infestations Sepsis 7.0
Blood and lymphatic system disorders Thrombocytopenia 7.0
Blood and lymphatic system disorders Anaemia 6.3
Gastrointestinal disorders Diarrhoea 6.3
Cardiac disorders Dyspnoea 6.3
General disorders and administration site conditions Asthenia 6.1
General disorders and administration site conditions Fatigue 6.1
Gastrointestinal disorders Abdominal pain 6.0
Blood and lymphatic system disorders Anaemia 6.0
General disorders and administration site conditions Asthenia 6.0
Investigations Body temperature increased 6.0
Skin and subcutaneous tissue disorders Dermatitis 6.0
Gastrointestinal disorders Diarrhoea 6.0
Cardiac disorders Dyspnoea 6.0
General disorders and administration site conditions Fatigue 6.0
Gastrointestinal disorders Gastrointestinal disorder 6.0
Gastrointestinal disorders Gastrointestinal pain 6.0
Investigations Haemoglobin 6.0
Vascular disorders Haemorrhage 6.0
Immune system disorders Hypersensitivity 6.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 6.0
Gastrointestinal disorders Nausea 6.0
Nervous system disorders Neuropathy peripheral 6.0
Blood and lymphatic system disorders Neutropenia 6.0
Infections and infestations Pneumonia 6.0
Skin and subcutaneous tissue disorders Rash 6.0
Blood and lymphatic system disorders Thrombocytopenia 6.0
Gastrointestinal disorders Abdominal pain 5.4
General disorders and administration site conditions Asthenia 5.4
Gastrointestinal disorders Constipation 5.4
Cardiac disorders Dyspnoea 5.4
Gastrointestinal disorders Gastrointestinal pain 5.4
Gastrointestinal disorders Abdominal pain 5.0
General disorders and administration site conditions Asthenia 5.0
Investigations Body temperature increased 5.0
Gastrointestinal disorders Constipation 5.0
General disorders and administration site conditions Discomfort 5.0
Cardiac disorders Dyspnoea 5.0
General disorders and administration site conditions Fatigue 5.0
General disorders and administration site conditions Feeling abnormal 5.0
Gastrointestinal disorders Gastrointestinal pain 5.0
General disorders and administration site conditions Ill-defined disorder 5.0
Infections and infestations Infection 5.0
Infections and infestations Infestation 5.0
Gastrointestinal disorders Intestinal obstruction 5.0
General disorders and administration site conditions Malaise 5.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 5.0
Gastrointestinal disorders Nausea 5.0
Blood and lymphatic system disorders Neutropenia 5.0
General disorders and administration site conditions Pain 5.0
Infections and infestations Sepsis 5.0
Blood and lymphatic system disorders Thrombocytopenia 5.0
Gastrointestinal disorders Intestinal obstruction 4.5
General disorders and administration site conditions Pain 4.5
Infections and infestations Sepsis 4.5
Gastrointestinal disorders Intestinal obstruction 4.4
Gastrointestinal disorders Abdominal pain 4.0
General disorders and administration site conditions Asthenia 4.0
Investigations Body temperature increased 4.0
General disorders and administration site conditions Decreased appetite 4.0
Gastrointestinal disorders Diarrhoea 4.0
Cardiac disorders Dyspnoea 4.0
General disorders and administration site conditions Fatigue 4.0
Blood and lymphatic system disorders Febrile neutropenia 4.0
Gastrointestinal disorders Gastrointestinal disorder 4.0
Gastrointestinal disorders Gastrointestinal pain 4.0
Infections and infestations Infection 4.0
Gastrointestinal disorders Intestinal obstruction 4.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 4.0
Musculoskeletal and connective tissue disorders Myalgia 4.0
Blood and lymphatic system disorders Neutropenia 4.0
General disorders and administration site conditions Pain 4.0
Gastrointestinal disorders Vomiting 4.0
General disorders and administration site conditions Decreased appetite 3.6
Gastrointestinal disorders Abdominal pain 3.5
General disorders and administration site conditions Asthenia 3.5
General disorders and administration site conditions Fatigue 3.5
Gastrointestinal disorders Gastrointestinal pain 3.5
General disorders and administration site conditions Pain 3.47
General disorders and administration site conditions Asthenia 3.4
Musculoskeletal and connective tissue disorders Arthralgia 3.0
General disorders and administration site conditions Asthenia 3.0
General disorders and administration site conditions Decreased appetite 3.0
Gastrointestinal disorders Diarrhoea 3.0
General disorders and administration site conditions Discomfort 3.0
Cardiac disorders Dyspnoea 3.0
General disorders and administration site conditions Fatigue 3.0
General disorders and administration site conditions Feeling abnormal 3.0
Investigations Haemoglobin 3.0
Vascular disorders Haemorrhage 3.0
Immune system disorders Hypersensitivity 3.0
General disorders and administration site conditions Ill-defined disorder 3.0
General disorders and administration site conditions Malaise 3.0
Metabolism and nutrition disorders Malnutrition 3.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 3.0
Musculoskeletal and connective tissue disorders Myalgia 3.0
Gastrointestinal disorders Nausea 3.0
General disorders and administration site conditions Pain 3.0
Infections and infestations Sepsis 3.0
Blood and lymphatic system disorders Thrombocytopenia 3.0
Gastrointestinal disorders Vomiting 3.0
Immune system disorders Hypersensitivity 2.78
Gastrointestinal disorders Nausea 2.7
Blood and lymphatic system disorders Thrombocytopenia 2.7
Gastrointestinal disorders Vomiting 2.7
Musculoskeletal and connective tissue disorders Arthralgia 2.6
General disorders and administration site conditions Asthenia 2.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.6
Musculoskeletal and connective tissue disorders Myalgia 2.6
General disorders and administration site conditions Asthenia 2.2
General disorders and administration site conditions Fatigue 2.2
General disorders and administration site conditions Pain 2.2
Investigations Haemoglobin 2.08
Vascular disorders Haemorrhage 2.08
Nervous system disorders Neuropathy peripheral 2.08
Gastrointestinal disorders Abdominal pain 2.0
Blood and lymphatic system disorders Anaemia 2.0
General disorders and administration site conditions Asthenia 2.0
Cardiac disorders Chest pain 2.0
Gastrointestinal disorders Constipation 2.0
Respiratory, thoracic and mediastinal disorders Cough 2.0
General disorders and administration site conditions Decreased appetite 2.0
Gastrointestinal disorders Diarrhoea 2.0
General disorders and administration site conditions Discomfort 2.0
Cardiac disorders Dyspnoea 2.0
General disorders and administration site conditions Fatigue 2.0
General disorders and administration site conditions Feeling abnormal 2.0
Gastrointestinal disorders Gastrointestinal pain 2.0
Investigations Haemoglobin 2.0
Vascular disorders Haemorrhage 2.0
Nervous system disorders Headache 2.0
General disorders and administration site conditions Ill-defined disorder 2.0
Infections and infestations Infection 2.0
Infections and infestations Infestation 2.0
General disorders and administration site conditions Malaise 2.0
Metabolism and nutrition disorders Malnutrition 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Musculoskeletal and connective tissue disorders Myalgia 2.0
Gastrointestinal disorders Nausea 2.0
Nervous system disorders Nervous system disorder 2.0
Nervous system disorders Neuropathy peripheral 2.0
Blood and lymphatic system disorders Neutropenia 2.0
General disorders and administration site conditions Pain 2.0
Infections and infestations Pneumonia 2.0
Infections and infestations Sepsis 2.0
Gastrointestinal disorders Stomatitis 2.0
Gastrointestinal disorders Vomiting 2.0
Blood and lymphatic system disorders Anaemia 1.9
Gastrointestinal disorders Diarrhoea 1.9
Gastrointestinal disorders Vomiting 1.9
General disorders and administration site conditions Asthenia 1.8
Cardiac disorders Chest pain 1.8
General disorders and administration site conditions Discomfort 1.8
Cardiac disorders Dyspnoea 1.8
General disorders and administration site conditions Fatigue 1.8
General disorders and administration site conditions Feeling abnormal 1.8
Nervous system disorders Headache 1.8
General disorders and administration site conditions Ill-defined disorder 1.8
General disorders and administration site conditions Malaise 1.8
Gastrointestinal disorders Nausea 1.8
Infections and infestations Sepsis 1.8
General disorders and administration site conditions Asthenia 1.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.5
Musculoskeletal and connective tissue disorders Myalgia 1.5
Gastrointestinal disorders Stomatitis 1.5
Immune system disorders Hypersensitivity 1.43
Gastrointestinal disorders Abdominal pain 1.3
Gastrointestinal disorders Gastrointestinal pain 1.3
Cardiac disorders Dyspnoea 1.2
General disorders and administration site conditions Discomfort 1.1
General disorders and administration site conditions Feeling abnormal 1.1
General disorders and administration site conditions Ill-defined disorder 1.1
General disorders and administration site conditions Malaise 1.1
Gastrointestinal disorders Abdominal pain 1.0
Musculoskeletal and connective tissue disorders Arthralgia 1.0
General disorders and administration site conditions Asthenia 1.0
Investigations Body temperature increased 1.0
Cardiac disorders Chest pain 1.0
Gastrointestinal disorders Constipation 1.0
Respiratory, thoracic and mediastinal disorders Cough 1.0
General disorders and administration site conditions Decreased appetite 1.0
Skin and subcutaneous tissue disorders Dermatitis 1.0
Gastrointestinal disorders Diarrhoea 1.0
General disorders and administration site conditions Discomfort 1.0
Cardiac disorders Dyspnoea 1.0
General disorders and administration site conditions Feeling abnormal 1.0
Gastrointestinal disorders Gastrointestinal pain 1.0
Investigations Haemoglobin 1.0
Vascular disorders Haemorrhage 1.0
Nervous system disorders Headache 1.0
Blood and lymphatic system disorders Hyperbilirubinaemia 1.0
Immune system disorders Hypersensitivity 1.0
General disorders and administration site conditions Ill-defined disorder 1.0
Gastrointestinal disorders Intestinal obstruction 1.0
General disorders and administration site conditions Malaise 1.0
Metabolism and nutrition disorders Malnutrition 1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.0
Gastrointestinal disorders Nausea 1.0
Nervous system disorders Nervous system disorder 1.0
Nervous system disorders Neuropathy peripheral 1.0
Blood and lymphatic system disorders Neutropenia 1.0
General disorders and administration site conditions Pain 1.0
Gastrointestinal disorders Pharyngitis 1.0
Skin and subcutaneous tissue disorders Rash 1.0
Infections and infestations Sepsis 1.0
Gastrointestinal disorders Stomatitis 1.0
Blood and lymphatic system disorders Thrombocytopenia 1.0
Gastrointestinal disorders Vomiting 1.0
Gastrointestinal disorders Abdominal pain 0.9
Musculoskeletal and connective tissue disorders Arthralgia 0.9
Cardiac disorders Chest pain 0.9
Skin and subcutaneous tissue disorders Dermatitis 0.9
Gastrointestinal disorders Diarrhoea 0.9
Gastrointestinal disorders Gastrointestinal pain 0.9
Nervous system disorders Headache 0.9
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.9
Skin and subcutaneous tissue disorders Rash 0.9
Gastrointestinal disorders Stomatitis 0.9
General disorders and administration site conditions Decreased appetite 0.8
Nervous system disorders Headache 0.8
Blood and lymphatic system disorders Hyperbilirubinaemia 0.8
Gastrointestinal disorders Intestinal obstruction 0.8
Infections and infestations Sepsis 0.8
Investigations Haemoglobin 0.694
Vascular disorders Haemorrhage 0.694
Immune system disorders Hypersensitivity 0.694
Nervous system disorders Neuropathy peripheral 0.694
Musculoskeletal and connective tissue disorders Arthralgia 0.5
General disorders and administration site conditions Discomfort 0.5
General disorders and administration site conditions Feeling abnormal 0.5
General disorders and administration site conditions Ill-defined disorder 0.5
General disorders and administration site conditions Malaise 0.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.5
Blood and lymphatic system disorders Thrombocytopenia 0.5
Gastrointestinal disorders Vomiting 0.5
Gastrointestinal disorders Diarrhoea 0.4
Gastrointestinal disorders Vomiting 0.4
Cardiac disorders Chest pain 0.3
General disorders and administration site conditions Discomfort 0.3
General disorders and administration site conditions Feeling abnormal 0.3
General disorders and administration site conditions Ill-defined disorder 0.3
General disorders and administration site conditions Malaise 0.3
Gastrointestinal disorders Nausea 0.3
Infections and infestations Sepsis 0.3
Musculoskeletal and connective tissue disorders Arthralgia 0.2
Gastrointestinal disorders Constipation 0.2
Skin and subcutaneous tissue disorders Dermatitis 0.2
Gastrointestinal disorders Diarrhoea 0.2
Nervous system disorders Headache 0.2
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.2
Skin and subcutaneous tissue disorders Rash 0.2
Gastrointestinal disorders Stomatitis 0.2
Skin and subcutaneous tissue disorders Alopecia 0.1
General disorders and administration site conditions Asthenia 0.1
General disorders and administration site conditions Fatigue 0.1

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
17.26
Blood and lymphatic system disorders
10.21
Investigations
9.02
Gastrointestinal disorders
7.94
Nervous system disorders
6.12
Respiratory, thoracic and mediastinal disorders
6.11
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
5.92
Vascular disorders
4.71
Infections and infestations
4.53
Skin and subcutaneous tissue disorders
4.51
Eye disorders
3.89
Metabolism and nutrition disorders
3.83
Injury, poisoning and procedural complications
3.23
Cardiac disorders
2.92

Cross References

Resources Reference
ChEBI 63632
ChEMBL CHEMBL1607
EPA CompTox DTXSID1045952
FDA SRS 956S425ZCY
Guide to Pharmacology 7101
KEGG C11158
PDB TTC
PubChem 60699
SureChEMBL SCHEMBL7247
ZINC ZINC35018256
CONTENTS