| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1986) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | B02AA02 |
| UNII: | 6T84R30KC1 |
Structure
| InChI Key | GYDJEQRTZSCIOI-LJGSYFOKSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C8H15NO2 |
| Molecular Weight | 157.21 |
| AlogP | 0.84 |
| Hydrogen Bond Acceptor | 2.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 63.32 |
| Molecular species | ZWITTERION |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 11.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Plasminogen inhibitor | DailyMed |
| Primary Target | |
|---|---|
| plasminogen |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Protease
Serine protease
Serine protease PA clan
Serine protease S1A subfamily
|
- | 3100-50000 | 1100-36000 | - | 10 | |
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 102 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Gastrointestinal Hemorrhage | 3 | D006471 | ClinicalTrials |
| Scoliosis | 3 | D012600 | ClinicalTrials |
| Angioedemas, Hereditary | 3 | D054179 | ClinicalTrials |
| Wounds and Injuries | 3 | D014947 | ClinicalTrials |
| Neoplasms | 3 | D009369 | ClinicalTrials |
| Leiomyoma | 3 | D007889 | ClinicalTrials |
| Thrombocytopenia | 3 | D013921 | ClinicalTrials |
| Aortic Aneurysm, Abdominal | 3 | D017544 | ClinicalTrials |
| Hematologic Neoplasms | 3 | D019337 | ClinicalTrials |
| Fractures, Bone | 3 | D050723 | ClinicalTrials |
| Head and Neck Neoplasms | 3 | D006258 | ClinicalTrials |
| Pelvic Organ Prolapse | 3 | D056887 | ClinicalTrials |
| Placenta Accreta | 3 | D010921 | ClinicalTrials |
| Placenta Previa | 3 | D010923 | ClinicalTrials |
| Joint Diseases | 3 | D007592 | ClinicalTrials |
| Femoral Neck Fractures | 3 | D005265 | ClinicalTrials |
| Hematoma, Subdural, Intracranial | 3 | D046648 | ClinicalTrials |
| Telangiectasia, Hereditary Hemorrhagic | 3 | D013683 | ClinicalTrials |
| Brain Neoplasms | 3 | D001932 | ClinicalTrials |
| Hip Fractures | 3 | D006620 | ClinicalTrials |
| Osteoarthritis | 3 | D010003 | ClinicalTrials |
| Brain Injuries | 3 | D001930 | ClinicalTrials |
| Hematologic Neoplasms | 3 | D019337 | ClinicalTrials |
| Meningioma | 3 | D008579 | ClinicalTrials |
| Coronary Disease | 3 | D003327 | ClinicalTrials |
| Pain | 3 | D010146 | ClinicalTrials |
| Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
| Hematoma | 3 | D006406 | ClinicalTrials |
| Bone Neoplasms | 3 | D001859 | ClinicalTrials |
| Shoulder Impingement Syndrome | 3 | D019534 | ClinicalTrials |
| Sepsis | 3 | D018805 | ClinicalTrials |
| Genital Neoplasms, Female | 3 | D005833 | ClinicalTrials |
| Melanosis | 3 | D008548 | ClinicalTrials |
| Anemia | 3 | D000740 | ClinicalTrials |
| Blood Coagulation Disorders | 3 | D001778 | ClinicalTrials |
| Postpartum Hemorrhage | 3 | D006473 | ClinicalTrials |
| Nasal Polyps | 3 | D009298 | ClinicalTrials |
| Astrocytoma | 3 | D001254 | ClinicalTrials |
| Glioma | 3 | D005910 | ClinicalTrials |
| Hemoptysis | 3 | D006469 | ClinicalTrials |
| Joint Diseases | 3 | D007592 | ClinicalTrials |
| Shock | 3 | D012769 | ClinicalTrials |
| Osteoarthritis, Knee | 2 | D020370 | ClinicalTrials |
| Subarachnoid Hemorrhage | 2 | D013345 | ClinicalTrials |
| Cerebral Hemorrhage | 2 | D002543 | ClinicalTrials |
| Ileus | 2 | D045823 | ClinicalTrials |
| Urinary Bladder Neoplasms | 2 | D001749 | ClinicalTrials |
| Epistaxis | 2 | D004844 | ClinicalTrials |
| Shock, Septic | 2 | D012772 | ClinicalTrials |
| Intervertebral Disc Degeneration | 2 | D055959 | ClinicalTrials |
| Hypotension | 0 | D007022 | ClinicalTrials |
| Skin Neoplasms | 0 | D012878 | ClinicalTrials |
| Back Pain | 0 | D001416 | ClinicalTrials |
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1197-18-8 |
| ChEBI | 48669 |
| ChEMBL | CHEMBL877 |
| DrugBank | DB00302 |
| DrugCentral | 2713 |
| FDA SRS | 6T84R30KC1 |
| Human Metabolome Database | HMDB0014447 |
| Guide to Pharmacology | 6573 |
| KEGG | C12535 |
| PDB | AMH |
| SureChEMBL | SCHEMBL16974 |
| ZINC | ZINC000100071256 |
CONTENTS