| Trade Names: | |
| Synonyms: | |
| Status: | Approved (2002) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | B01AC21 |
| UNII: | RUM6K67ESG |
Structure
| InChI Key | PAJMKGZZBBTTOY-ZFORQUDYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H34O5 |
| Molecular Weight | 390.52 |
| AlogP | 3.58 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 10.0 |
| Polar Surface Area | 86.99 |
| Molecular species | ACID |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 28.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Prostanoid IP receptor agonist |
| Primary Target | |
|---|---|
| IP receptor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | - | - | - | 12.6 | |
|
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Lipid-like ligand receptor (family A GPCR)
Prostanoid receptor
|
0.6 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Hypertension, Pulmonary | 4 | D006976 | ClinicalTrials |
| Hypertension, Pulmonary | 4 | D006976 | ClinicalTrials |
| Lung Diseases, Interstitial | 3 | D017563 | ClinicalTrials |
| Familial Primary Pulmonary Hypertension | 3 | D065627 | ClinicalTrials |
| Idiopathic Pulmonary Fibrosis | 3 | D054990 | ClinicalTrials |
| Pulmonary Fibrosis | 3 | D011658 | ClinicalTrials |
| Persistent Fetal Circulation Syndrome | 2 | D010547 | ClinicalTrials |
| Pulmonary Disease, Chronic Obstructive | 2 | D029424 | ClinicalTrials |
| Ischemia | 2 | D007511 | ClinicalTrials |
| Hernias, Diaphragmatic, Congenital | 2 | D065630 | ClinicalTrials |
| Peripheral Vascular Diseases | 2 | D016491 | ClinicalTrials |
| Respiratory Distress Syndrome | 2 | D012128 | ClinicalTrials |
| Scleroderma, Systemic | 1 | D012595 | ClinicalTrials |
| Reperfusion Injury | 1 | D015427 | ClinicalTrials |
| Diabetes Mellitus, Type 1 | 1 | D003922 | ClinicalTrials |
| Raynaud Disease | 1 | D011928 | ClinicalTrials |
| Diabetic Foot | 1 | D017719 | ClinicalTrials |
Related Entries
Side Effects from Label
Side Effects (PT)
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 81846-19-7 |
| ChEBI | 50861 |
| ChEMBL | CHEMBL1237119 |
| DrugBank | DB00374 |
| DrugCentral | 2720 |
| FDA SRS | RUM6K67ESG |
| Human Metabolome Database | HMDB0014518 |
| Guide to Pharmacology | 5820 |
| PubChem | 6918140 |
| SureChEMBL | SCHEMBL4349618 |
| ZINC | ZINC000003800475 |
CONTENTS