TROPICAMIDE

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Trade Names:	MYDRIACYL MYDRIAFAIR TROPICACYL TROPICAMIDE
Synonyms:	BISTROPAMIDE MYDRIACYL MYDRIAFAIR NODS NSC-757372 RO-1-7683 TROPICACYL TROPICAMIDA TROPICAMIDE COMPONENT OF MYDCOMBI TROPICAMIDE COMPONENT OF PAREMYD TROPICAMIDUM VISUMIDRIATIC
Status:	Approved (1960)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	S01FA06
UNII:	N0A3Z5XTC6

Structure


InChI Key	BGDKAVGWHJFAGW-UHFFFAOYSA-N
Smile	CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1
InChI	InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H20N2O2
Molecular Weight	284.36
AlogP	2.21
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	53.43
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Action	Mechanism of Action	Reference
ANTAGONIST	Muscarinic acetylcholine receptor M3 antagonist

	Primary Target
M₃ receptor

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C19	-	1000	-	-	-
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9	-	1000	-	-	-
Enzyme Hydrolase	-	-	-	-	1.021
Enzyme	-	1000	-	-	1.021
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb	-	-	-	-	-8.99--5.17
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	105	-	30	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	75.11
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	150900	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Eye Diseases	3	D005128	ClinicalTrials
Sialorrhea	2	D012798	ClinicalTrials
Presbyopia	2	D011305	ClinicalTrials
Parkinson Disease	2	D010300	ClinicalTrials
Ocular Hypertension	1	D009798	ClinicalTrials

Related Entries

Mixture

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Eye disorders	24.5
Nervous system disorders	18.59
General disorders and administration site conditions	9.37
Gastrointestinal disorders	5.91
Skin and subcutaneous tissue disorders	5.33
Cardiac disorders	5.04
Immune system disorders	5.04
Injury, poisoning and procedural complications	4.61
Vascular disorders	4.61
Psychiatric disorders	4.03
Respiratory, thoracic and mediastinal disorders	3.89
Investigations	3.03

Cross References

Resources	Reference
CAS NUMBER	1508-75-4
ChEBI	9757
ChEMBL	CHEMBL1200604
DrugBank	DB00809
DrugCentral	2774
EPA CompTox	DTXSID8045220
FDA SRS	N0A3Z5XTC6
Human Metabolome Database	HMDB14947
Guide to Pharmacology	7319
KEGG	D00397
PharmGKB	PA164749389
PubChem	5593
SureChEMBL	SCHEMBL23975
ZINC	ZINC00057533

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