Trade Names: | |
Synonyms: | |
Status: | Approved (2006) |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
ATC: | L01XH01 |
UNII: | 58IFB293JI |
InChI Key | WAEXFXRVDQXREF-UHFFFAOYSA-N |
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Smile | |
InChI |
|
Property Name | Value |
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Molecular Formula | C14H20N2O3 |
Molecular Weight | 264.32 |
AlogP | 2.47 |
Hydrogen Bond Acceptor | 3.0 |
Hydrogen Bond Donor | 3.0 |
Number of Rotational Bond | 8.0 |
Polar Surface Area | 78.43 |
Molecular species | NEUTRAL |
Aromatic Rings | 1.0 |
Heavy Atoms | 19.0 |
Action | Mechanism of Action | Reference |
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INHIBITOR | Histone deacetylase 1 inhibitor | DailyMed |
Primary Target | |
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histone deacetylase 1 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Neoplasms | 4 | D009369 | ClinicalTrials |
Neoplasms | 4 | D009369 | ClinicalTrials |
Lung Neoplasms | 3 | D008175 | ClinicalTrials |
Multiple Myeloma | 3 | D009101 | ClinicalTrials |
Leukemia, Myeloid, Acute | 3 | D015470 | ClinicalTrials |
Lymphoma | 3 | D008223 | ClinicalTrials |
Mesothelioma | 3 | D008654 | ClinicalTrials |
Mesothelioma | 3 | D008654 | ClinicalTrials |
Mycosis Fungoides | 2 | D009182 | ClinicalTrials |
Gliosarcoma | 2 | D018316 | ClinicalTrials |
Ovarian Neoplasms | 2 | D010051 | ClinicalTrials |
Leukemia, Lymphocytic, Chronic, B-Cell | 2 | D015451 | ClinicalTrials |
Lymphoma, Follicular | 2 | D008224 | ClinicalTrials |
Lymphoma, B-Cell, Marginal Zone | 2 | D018442 | ClinicalTrials |
Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2 | D054198 | ClinicalTrials |
Prostatic Neoplasms, Castration-Resistant | 2 | D064129 | ClinicalTrials |
Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
Neuroblastoma | 2 | D009447 | ClinicalTrials |
Sarcoma | 2 | D012509 | ClinicalTrials |
Brain Diseases | 2 | D001927 | ClinicalTrials |
HIV Infections | 2 | D015658 | ClinicalTrials |
Myelodysplastic Syndromes | 2 | D009190 | ClinicalTrials |
Breast Neoplasms, Male | 2 | D018567 | ClinicalTrials |
Carcinoma, Renal Cell | 2 | D002292 | ClinicalTrials |
Anemia, Sickle Cell | 2 | D000755 | ClinicalTrials |
Carcinoma, Renal Cell | 2 | D002292 | ClinicalTrials |
Glioblastoma | 2 | D005909 | ClinicalTrials |
Leukemia | 2 | D007938 | ClinicalTrials |
Prostatic Neoplasms | 2 | D011471 | ClinicalTrials |
Astrocytoma | 2 | D001254 | ClinicalTrials |
Spinal Cord Neoplasms | 2 | D013120 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Lymphoma, Non-Hodgkin | 2 | D008228 | ClinicalTrials |
Sezary Syndrome | 2 | D012751 | ClinicalTrials |
Lymphoma, Mantle-Cell | 2 | D020522 | ClinicalTrials |
Colorectal Neoplasms | 2 | D015179 | ClinicalTrials |
Sarcoma | 2 | D012509 | ClinicalTrials |
Ovarian Neoplasms | 2 | D010051 | ClinicalTrials |
Colorectal Neoplasms | 2 | D015179 | ClinicalTrials |
Thrombocythemia, Essential | 2 | D013920 | ClinicalTrials |
Thyroid Neoplasms | 2 | D013964 | ClinicalTrials |
Polycythemia Vera | 2 | D011087 | ClinicalTrials |
Rectal Neoplasms | 2 | D012004 | ClinicalTrials |
Pituitary ACTH Hypersecretion | 2 | D047748 | ClinicalTrials |
Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2 | D054198 | ClinicalTrials |
Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2 | D054198 | ClinicalTrials |
Brain Neoplasms | 2 | D001932 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Ovarian Neoplasms | 2 | D010051 | ClinicalTrials |
HIV Infections | 2 | D015658 | ClinicalTrials |
Carcinoma, Medullary | 2 | D018276 | ClinicalTrials |
Lymphoma, Follicular | 2 | D008224 | ClinicalTrials |
Leukemia, Biphenotypic, Acute | 2 | D015456 | ClinicalTrials |
Colonic Neoplasms | 2 | D003110 | ClinicalTrials |
Brain Neoplasms | 2 | D001932 | ClinicalTrials |
Urinary Bladder Neoplasms | 2 | D001749 | ClinicalTrials |
Liver Neoplasms | 1 | D008113 | ClinicalTrials |
Alzheimer Disease | 1 | D000544 | ClinicalTrials |
Glioma | 1 | D005910 | ClinicalTrials |
Burkitt Lymphoma | 1 | D002051 | ClinicalTrials |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 1 | D015464 | ClinicalTrials |
Skin Neoplasms | 1 | D012878 | ClinicalTrials |
Crohn Disease | 1 | D003424 | ClinicalTrials |
Lymphoma, Large B-Cell, Diffuse | 1 | D016403 | ClinicalTrials |
Esophageal Neoplasms | 1 | D004938 | ClinicalTrials |
Hypopharyngeal Neoplasms | 1 | D007012 | ClinicalTrials |
Diffuse Intrinsic Pontine Glioma | 1 | D000080443 | ClinicalTrials |
Leukemia, Promyelocytic, Acute | 1 | D015473 | ClinicalTrials |
Small Cell Lung Carcinoma | 1 | D055752 | ClinicalTrials |
Lymphoma, T-Cell, Peripheral | 1 | D016411 | ClinicalTrials |
Oropharyngeal Neoplasms | 1 | D009959 | ClinicalTrials |
Oligodendroglioma | 1 | D009837 | ClinicalTrials |
Medulloblastoma | 1 | D008527 | ClinicalTrials |
Hodgkin Disease | 1 | D006689 | ClinicalTrials |
Squamous Cell Carcinoma of Head and Neck | 1 | D000077195 | ClinicalTrials |
Melanoma | 1 | D008545 | ClinicalTrials |
Carcinoma, Verrucous | 1 | D018289 | ClinicalTrials |
Leukemia, Myelomonocytic, Juvenile | 1 | D054429 | ClinicalTrials |
Stomach Neoplasms | 1 | D013274 | ClinicalTrials |
Niemann-Pick Diseases | 1 | D009542 | ClinicalTrials |
Pancreatic Neoplasms | 1 | D010190 | ClinicalTrials |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | D054218 | ClinicalTrials |
Anus Neoplasms | 1 | D001005 | ClinicalTrials |
Peritoneal Neoplasms | 1 | D010534 | ClinicalTrials |
Fallopian Tube Neoplasms | 1 | D005185 | ClinicalTrials |
Schizophrenia | 0 | D012559 | ClinicalTrials |
Resources | Reference |
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CAS NUMBER | 149647-78-9 |
ChEBI | 45716 |
ChEMBL | CHEMBL98 |
DrugBank | DB02546 |
DrugCentral | 4124 |
EPA CompTox | DTXSID6041133 |
FDA SRS | 58IFB293JI |
Human Metabolome Database | HMDB0015568 |
Guide to Pharmacology | 6852 |
KEGG | D06320 |
PDB | SHH |
PharmGKB | PA164748224 |
PubChem | 5311 |
SureChEMBL | SCHEMBL9018 |
ZINC | ZINC000001543873 |