ABT-384

Search structure


Synonyms:	Abt-384
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	R5TH77F919

Structure


InChI Key	CLHMYBJIOZXCEX-QIGVQZHLSA-N
Smile	CC(C)(C(=O)NC1C2CC3CC1CC(C(N)=O)(C3)C2)N1CCN(c2ccc(C(F)(F)F)cn2)CC1
InChI	InChI=1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)/t15?,16?,17?,20-,24?

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H34F3N5O2
Molecular Weight	493.57
AlogP	2.8
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	91.56
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	35.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	11-beta-hydroxysteroid dehydrogenase 1 inhibitor	PubMed PubMed PubMed

	Primary Target
hydroxysteroid 11-beta dehydrogenase 1

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Alzheimer Disease	2	D000544	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Cross References

Resources	Reference
CAS NUMBER	868623-40-9
ChEMBL	CHEMBL4297256
FDA SRS	R5TH77F919
Guide to Pharmacology	7357
PubChem	11670435

CONTENTS