AFEGOSTAT TARTRATE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 285ZJJ9773

Structure
InChI Key ULBPPCHRAVUQMC-RWOHWRPJSA-N
Smile O=C(O)C(O)C(O)C(=O)O.OC[C@H]1CNC[C@@H](O)[C@@H]1O
InChI
InChI=1S/C6H13NO3.C4H6O6/c8-3-4-1-7-2-5(9)6(4)10;5-1(3(7)8)2(6)4(9)10/h4-10H,1-3H2;1-2,5-6H,(H,7,8)(H,9,10)/t4-,5-,6-;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H19NO9
Molecular Weight 297.26
AlogP -2.08
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 1.0
Polar Surface Area 72.72
Molecular species BASE
Aromatic Rings 0.0
Heavy Atoms 10.0

Pharmacology

Action Mechanism of Action Reference
STABILISER Beta-glucocerebrosidase stabiliser PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme
- 19-2700 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Gaucher Disease 2 D005776 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL2105671
FDA SRS 285ZJJ9773
PubChem 23581846
SureChEMBL SCHEMBL20641234
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