AMUVATINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: SO9S6QZB4R

Structure
InChI Key FOFDIMHVKGYHRU-UHFFFAOYSA-N
Smile S=C(NCc1ccc2c(c1)OCO2)N1CCN(c2ncnc3c2oc2ccccc23)CC1
InChI
InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H21N5O3S
Molecular Weight 447.52
AlogP 3.3
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 75.89
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor PubMed Other PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 850879-09-3
ChEBI 91389
ChEMBL CHEMBL2103851
DrugBank DB12742
EPA CompTox DTXSID50234176
FDA SRS SO9S6QZB4R
Guide to Pharmacology 7932
PubChem 11282283
SureChEMBL SCHEMBL93976
ZINC ZINC000034951302
CONTENTS