AV-101

Search structure


Synonyms:	4-chlorokynurenine 4-cl-kyn Av-101 J578.071C L-4-chlorokynurenine L-4-cl-kyn
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN Prodrug
UNII:	77XLH9L40B

Structure


InChI Key	HQLHZNDJQSRKDT-UHFFFAOYSA-N
Smile	Nc1cc(Cl)ccc1C(=O)CC(N)C(=O)O
InChI	InChI=1S/C10H11ClN2O3/c11-5-1-2-6(7(12)3-5)9(14)4-8(13)10(15)16/h1-3,8H,4,12-13H2,(H,15,16)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C10H11ClN2O3
Molecular Weight	242.66
AlogP	0.91
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	106.41
Molecular species	ZWITTERION
Aromatic Rings	1.0
Heavy Atoms	16.0

Pharmacology

Action	Mechanism of Action	Reference
ANTAGONIST	Glutamate [NMDA] receptor antagonist	Wikipedia Other PubMed

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Depressive Disorder, Major	2	D003865	ClinicalTrials
Depressive Disorder	2	D003866	ClinicalTrials
Neuralgia	1	D009437	ClinicalTrials

Cross References

Resources	Reference
CAS NUMBER	153152-32-0
ChEMBL	CHEMBL3545351
FDA SRS	77XLH9L40B
PubChem	9859632
SureChEMBL	SCHEMBL5286788

CONTENTS