AVIBACTAM

Search structure
Synonyms:
Status: Approved (2015)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 06MFO7817I

Structure
InChI Key NDCUAPJVLWFHHB-UHNVWZDZSA-N
Smile NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
InChI
InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H11N3O6S
Molecular Weight 265.25
AlogP -1.53
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 130.24
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 17.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 100 - 11 50
Enzyme
- 100 - 11 50

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Pyelonephritis 3 D011704 ClinicalTrials
Pneumonia 3 D011014 ClinicalTrials
Infections 3 D007239 ClinicalTrials
Urinary Tract Infections 2 D014552 ClinicalTrials
Systemic Inflammatory Response Syndrome 1 D018746 ClinicalTrials
Bacterial Infections 1 D001424 ClinicalTrials
Renal Insufficiency 1 D051437 ClinicalTrials

Related Entries

MCS

Cross References

Resources Reference
CAS NUMBER 1192500-31-4
ChEBI 85984
ChEMBL CHEMBL1689063
DrugBank DB09060
DrugCentral 4946
FDA SRS 06MFO7817I
Guide to Pharmacology 10761
PDB FYG
PubChem 9835049
SureChEMBL SCHEMBL1666807
ZINC ZINC000009302239
CONTENTS