BIFEPRUNOX

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: AP69E83Z79

Structure
InChI Key CYGODHVAJQTCBG-UHFFFAOYSA-N
Smile O=c1[nH]c2cccc(N3CCN(Cc4cccc(-c5ccccc5)c4)CC3)c2o1
InChI
InChI=1S/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H23N3O2
Molecular Weight 385.47
AlogP 4.11
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 52.48
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
PARTIAL AGONIST Dopamine D2 receptor partial agonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 3 - 0-2 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
324 - - 9-9 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 3 D000544 ClinicalTrials
Schizophrenia 3 D012559 ClinicalTrials
Bipolar Disorder 3 D001714 ClinicalTrials
Depressive Disorder 3 D003866 ClinicalTrials
Bipolar Disorder 3 D001714 ClinicalTrials
Psychotic Disorders 2 D011618 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 350992-10-8
ChEMBL CHEMBL218166
DrugBank DB04888
EPA CompTox DTXSID80188592
FDA SRS AP69E83Z79
PubChem 208951
SureChEMBL SCHEMBL114371
ZINC ZINC000052971454
CONTENTS