BMS-823778

Search structure


Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	C82R061MZ5

Structure


InChI Key	PTIFVLOBVCIMKL-UHFFFAOYSA-N
Smile	CC(C)(O)c1cccn2c(C3(c4ccc(Cl)cc4)CC3)nnc12
InChI	InChI=1S/C18H18ClN3O/c1-17(2,23)14-4-3-11-22-15(14)20-21-16(22)18(9-10-18)12-5-7-13(19)8-6-12/h3-8,11,23H,9-10H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H19Cl2N3O
Molecular Weight	364.28
AlogP	3.69
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	50.42
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	23.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	11-beta-hydroxysteroid dehydrogenase 1 inhibitor

	Primary Target
hydroxysteroid 11-beta dehydrogenase 1

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Cardiovascular Diseases	2	D002318	ClinicalTrials
Hypertension	2	D006973	ClinicalTrials
Lipid Metabolism Disorders	2	D052439	ClinicalTrials
Diabetes Mellitus, Type 2	2	D003924	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL4297457
FDA SRS	C82R061MZ5
Guide to Pharmacology	10158
PubChem	54669979
SureChEMBL	SCHEMBL647628
ChEMBL	CHEMBL4301600
FDA SRS	C82R061MZ5
Guide to Pharmacology	10158
PDB	HJG
PubChem	54669979
SureChEMBL	SCHEMBL646462

CONTENTS