| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 8JYO8VTR11 |
Structure
| InChI Key | PTIFVLOBVCIMKL-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H19Cl2N3O |
| Molecular Weight | 364.28 |
| AlogP | 3.69 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 50.42 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 23.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | PubMed |
| Primary Target | |
|---|---|
| hydroxysteroid 11-beta dehydrogenase 1 |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Oxidoreductase
|
- | 2 | - | 1 | - | |
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | - | - | - | 20-31 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Cardiovascular Diseases | 2 | D002318 | ClinicalTrials |
| Hypertension | 2 | D006973 | ClinicalTrials |
| Diabetes Mellitus, Type 2 | 2 | D003924 | ClinicalTrials |
| Lipid Metabolism Disorders | 2 | D052439 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4301600 |
| FDA SRS | 8JYO8VTR11 |
| Guide to Pharmacology | 10158 |
| PDB | HJG |
| PubChem | 54669979 |
| SureChEMBL | SCHEMBL646462 |
| ChEMBL | CHEMBL4297457 |
| FDA SRS | C82R061MZ5 |
| Guide to Pharmacology | 10158 |
| PubChem | 54669979 |
| SureChEMBL | SCHEMBL647628 |
CONTENTS