BRANAPLAM

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: P12R69543A

Structure
InChI Key STWTUEAWRAIWJG-UHFFFAOYSA-N
Smile CC1(C)CC(Oc2ccc(-c3ccc(-c4cn[nH]c4)cc3O)nn2)CC(C)(C)N1
InChI
InChI=1S/C22H27N5O2/c1-21(2)10-16(11-22(3,4)27-21)29-20-8-7-18(25-26-20)17-6-5-14(9-19(17)28)15-12-23-24-13-15/h5-9,12-13,16,27-28H,10-11H2,1-4H3,(H,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H27N5O2
Molecular Weight 393.49
AlogP 3.93
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 95.95
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 29.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 6300 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Muscular Atrophy, Spinal 1 D009134 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1562338-42-4
ChEMBL CHEMBL4290141
DrugBank DB14918
FDA SRS P12R69543A
PubChem 135565042
SureChEMBL SCHEMBL15475826
ZINC ZINC000146605125
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