CAMICINAL

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 3C8348951H

Structure
InChI Key RZKDEGZIFSJVNA-IBGZPJMESA-N
Smile C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)CCN1
InChI
InChI=1S/C25H33FN4O/c1-19-17-29(14-11-27-19)18-21-7-5-20(6-8-21)15-25(31)30-12-9-23(10-13-30)28-24-4-2-3-22(26)16-24/h2-8,16,19,23,27-28H,9-15,17-18H2,1H3/t19-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H33FN4O
Molecular Weight 424.56
AlogP 3.27
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 47.61
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Motilin receptor agonist PubMed
Primary Target
motilin receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6
- 34000 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4
- 26000-69000 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 15849 - - -
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Motilin receptor
13 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Gastroparesis 2 D018589 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 923565-21-3
ChEMBL CHEMBL489095
DrugBank DB12567
FDA SRS 3C8348951H
Guide to Pharmacology 4035
PubChem 15984937
SureChEMBL SCHEMBL1704099
ZINC ZINC000034850365
CONTENTS