CEBRANOPADOL

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 7GDW9S3GN3

Structure
InChI Key CSMVOZKEWSOFER-RQNOJGIXSA-N
Smile CN(C)[C@]1(c2ccccc2)CC[C@]2(CC1)OCCc1c3cc(F)ccc3[nH]c12
InChI
InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3/t23-,24-

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H27FN2O
Molecular Weight 378.49
AlogP 5.11
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 28.26
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Nociceptin receptor agonist PubMed Wikipedia PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor
1 - - 1 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteoarthritis, Knee 2 D020370 ClinicalTrials
Pain 2 D010146 ClinicalTrials
Low Back Pain 2 D017116 ClinicalTrials
Diabetic Neuropathies 2 D003929 ClinicalTrials
Substance-Related Disorders 1 D019966 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 863513-91-1
ChEMBL CHEMBL2364605
DrugBank DB12830
FDA SRS 7GDW9S3GN3
Guide to Pharmacology 8866
PubChem 11848225
SureChEMBL SCHEMBL10035739
CONTENTS