Synonyms: | |
Status: | Approved (1950) |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | 3U6IO1965U |
InChI Key | SOYKEARSMXGVTM-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C16H19ClN2 |
Molecular Weight | 274.8 |
AlogP | 3.82 |
Hydrogen Bond Acceptor | 2.0 |
Hydrogen Bond Donor | 0.0 |
Number of Rotational Bond | 5.0 |
Polar Surface Area | 16.13 |
Molecular species | BASE |
Aromatic Rings | 2.0 |
Heavy Atoms | 19.0 |
Primary Target | |
---|---|
H1 receptor |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Epigenetic regulator
Reader
Methyl-lysine/arginine binding protein
MBT domain
|
- | 34000 | - | - | - | |
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 1100-20893 | - | - | - | |
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | 10000 | - | - | 50 | |
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Monoamine receptor
Histamine receptor
|
- | 66 | - | 1-7 | 41 | |
Transporter
|
- | 54000 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Hypersensitivity | 4 | D006967 | ClinicalTrials |
Influenza, Human | 3 | D007251 | ClinicalTrials |
Rhinitis, Allergic, Seasonal | 2 | D006255 | ClinicalTrials |
Sunburn | 2 | D013471 | ClinicalTrials |
Hepatitis B, Chronic | 2 | D019694 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 132-22-9 |
ChEBI | 52010 |
ChEMBL | CHEMBL505 |
DrugBank | DB01114 |
DrugCentral | 616 |
EPA CompTox | DTXSID0022804 |
FDA SRS | 3U6IO1965U |
Human Metabolome Database | HMDB0001944 |
Guide to Pharmacology | 6976 |
KEGG | C06905 |
PharmGKB | PA448960 |
PubChem | 2725 |
SureChEMBL | SCHEMBL4219 |