CXA-10

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 1N19AGY57Y

Structure
InChI Key WRADPCFZZWXOTI-BMRADRMJSA-N
Smile CCCCCCCC/C(=C\CCCCCCCC(=O)O)[N+](=O)[O-]
InChI
InChI=1S/C18H33NO4/c1-2-3-4-5-8-11-14-17(19(22)23)15-12-9-6-7-10-13-16-18(20)21/h15H,2-14,16H2,1H3,(H,20,21)/b17-15+

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H33NO4
Molecular Weight 327.46
AlogP 5.71
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 16.0
Polar Surface Area 80.44
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 23.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3
- 1610 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Asthma 2 D001249 ClinicalTrials
Hypertension, Pulmonary 2 D006976 ClinicalTrials
Glomerulosclerosis, Focal Segmental 2 D005923 ClinicalTrials
Acute Kidney Injury 1 D058186 ClinicalTrials

Related Entries

MCS

Cross References

Resources Reference
CAS NUMBER 875685-46-4
ChEBI 86285
ChEMBL CHEMBL561371
DrugBank DB15026
FDA SRS 1N19AGY57Y
Human Metabolome Database HMDB0062737
PubChem 24836820
SureChEMBL SCHEMBL1018141
ZINC ZINC000040331256
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