| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | M17ILL71MC |
Structure
| InChI Key | JCYNMRJCUYVDBC-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C27H26N4O4S |
| Molecular Weight | 502.6 |
| AlogP | 5.04 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 108.47 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 36.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transcription factor
Nuclear receptor
Nuclear hormone receptor subfamily 1
Nuclear hormone receptor subfamily 1 group C
Nuclear hormone receptor subfamily 1 group C member 3
|
0-1 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Thyroid Neoplasms | 2 | D013964 | ClinicalTrials |
| Liposarcoma | 2 | D008080 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
| Colorectal Neoplasms | 2 | D015179 | ClinicalTrials |
| Colorectal Neoplasms | 2 | D015179 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Multiple Myeloma | 1 | D009101 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Related Entries
MCS
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 223132-37-4 |
| ChEMBL | CHEMBL3545280 |
| DrugBank | DB11894 |
| FDA SRS | M17ILL71MC |
| PubChem | 9832447 |
| SureChEMBL | SCHEMBL3246054 |
CONTENTS