ELVUCITABINE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: M09BUF90C0

Structure
InChI Key HSBKFSPNDWWPSL-VDTYLAMSSA-N
Smile Nc1nc(=O)n([C@@H]2C=C[C@H](CO)O2)cc1F
InChI
InChI=1S/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H10FN3O3
Molecular Weight 227.19
AlogP -0.59
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 90.37
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 16.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA polymerase/reverse transcriptase inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
140-180 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
HIV Infections 2 D015658 ClinicalTrials
HIV Infections 2 D015658 ClinicalTrials
Hepatitis B, Chronic 2 D019694 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 181785-84-2
ChEMBL CHEMBL38700
DrugBank DB06236
EPA CompTox DTXSID20171185
FDA SRS M09BUF90C0
PubChem 469717
SureChEMBL SCHEMBL1649928
ZINC ZINC000000007048
CONTENTS