Synonyms: | |
Status: | Approved (2019) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | N01AX14 |
UNII: | 50LFG02TXD |
InChI Key | YQEZLKZALYSWHR-ZDUSSCGKSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C13H16ClNO |
Molecular Weight | 237.73 |
AlogP | 2.9 |
Hydrogen Bond Acceptor | 2.0 |
Hydrogen Bond Donor | 1.0 |
Number of Rotational Bond | 2.0 |
Polar Surface Area | 29.1 |
Molecular species | NEUTRAL |
Aromatic Rings | 1.0 |
Heavy Atoms | 16.0 |
Action | Mechanism of Action | Reference |
---|---|---|
NEGATIVE ALLOSTERIC MODULATOR | Glutamate [NMDA] receptor negative allosteric modulator | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Ion channel
Ligand-gated ion channel
Ionotropic glutamate receptor
NMDA receptor
|
- | 11 | - | 300-960 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Depressive Disorder | 4 | D003866 | ClinicalTrials |
Depressive Disorder, Major | 3 | D003865 | ClinicalTrials |
Neoplasms | 2 | D009369 | ClinicalTrials |
Kidney Diseases | 1 | D007674 | ClinicalTrials |
Substance-Related Disorders | 1 | D019966 | ClinicalTrials |
Rhinitis, Allergic, Seasonal | 1 | D006255 | ClinicalTrials |
Liver Diseases | 1 | D008107 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 33643-46-8 |
ChEBI | 60799 |
ChEMBL | CHEMBL395091 |
DrugBank | DB11823 |
DrugCentral | 4468 |
EPA CompTox | DTXSID6047810 |
FDA SRS | 50LFG02TXD |
Guide to Pharmacology | 9152 |
PDB | JC9 |
PubChem | 182137 |
SureChEMBL | SCHEMBL5512024 |
ZINC | ZINC000035999642 |