FAMITINIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: Parent
UNII: 768FW21J3L

Structure
InChI Key GKEYKDOLBLYGRB-LGMDPLHJSA-N
Smile CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O
InChI
InChI=1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H27FN4O2
Molecular Weight 410.49
AlogP 3.3
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 68.44
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Platelet-derived growth factor receptor inhibitor DOI PubMed ClinicalTrials
Primary Target
kinase insert domain receptor
KIT proto-oncogene, receptor tyrosine kinase
platelet derived growth factor receptor beta
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 2 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 2-5 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Colorectal Neoplasms 3 D015179 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Gastrointestinal Stromal Tumors 3 D046152 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 1044040-56-3
ChEMBL CHEMBL1278146
DrugBank DB11741
FDA SRS 768FW21J3L
Guide to Pharmacology 7886
PubChem 16662431
SureChEMBL SCHEMBL137251
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