Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: J05AX27
UNII: EW5GL2X7E0

Structure

InChI Key ZCGNOVWYSGBHAU-UHFFFAOYSA-N
Smile NC(=O)c1nc(F)cnc1O
InChI
InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)

Physicochemical Descriptors

Property Name Value
Molecular Formula C5H4FN3O2
Molecular Weight 157.1
AlogP -0.58
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 89.1
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 11.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR RNA-directed RNA polymerase inhibitor PMDA PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Influenza, Human 3 D007251 ClinicalTrials
Lassa Fever 2 D007835 ClinicalTrials
Hemorrhagic Fever, Ebola 2 D019142 ClinicalTrials
Pneumonia, Viral 1 D011024 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 259793-96-9
ChEBI 134722
ChEMBL CHEMBL221722
DrugBank DB12466
DrugCentral 4887
FDA SRS EW5GL2X7E0
Guide to Pharmacology 11139
PubChem 492405
SureChEMBL SCHEMBL587913
ZINC ZINC000013915654