FIPAMEZOLE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: T5RCK09KHV

Structure
InChI Key KXSUAWAUCNFBQJ-UHFFFAOYSA-N
Smile CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1
InChI
InChI=1S/C14H15FN2/c1-2-14(13-8-16-9-17-13)6-10-3-4-12(15)5-11(10)7-14/h3-5,8-9H,2,6-7H2,1H3,(H,16,17)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H15FN2
Molecular Weight 230.29
AlogP 3.0
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 28.68
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Adrenergic receptor alpha-2 antagonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Parkinson Disease 2 D010300 ClinicalTrials

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 150586-58-6
ChEMBL CHEMBL1255582
DrugBank DB06585
FDA SRS T5RCK09KHV
PubChem 213041
SureChEMBL SCHEMBL18826053
CONTENTS