FLECAINIDE

Search structure
Synonyms:
Status: Approved (1985)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C01BC04
UNII: K94FTS1806

Structure
InChI Key DJBNUMBKLMJRSA-UHFFFAOYSA-N
Smile O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F
InChI
InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H20F6N2O3
Molecular Weight 414.35
AlogP 3.44
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 59.59
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 28.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 3891-3891 - - -
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- 27100 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 6500 - - 74

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Atrial Fibrillation 3 D001281 ClinicalTrials
Arrhythmogenic Right Ventricular Dysplasia 2 D019571 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 54143-55-4
ChEBI 75984
ChEMBL CHEMBL652
DrugBank DB01195
DrugCentral 1176
EPA CompTox DTXSID8023054
FDA SRS K94FTS1806
Human Metabolome Database HMDB0015326
Guide to Pharmacology 2560
KEGG C07001
PharmGKB PA449646
PubChem 3356
SureChEMBL SCHEMBL14970
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