FOSBRETABULIN TROMETHAMINE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: Salt
UNII: GBW044919E
Parent Compound: FOSBRETABULIN

Structure
InChI Key FIDMEHCRMLKKPZ-YSMBQZINSA-N
Smile COc1ccc(/C=C\c2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O)O.NC(CO)(CO)CO
InChI
InChI=1S/C18H21O8P.C4H11NO3/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;5-4(1-6,2-7)3-8/h5-11H,1-4H3,(H2,19,20,21);6-8H,1-3,5H2/b6-5-;

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H32NO11P
Molecular Weight 517.47
AlogP 3.36
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 8.0
Polar Surface Area 103.68
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
DISRUPTING AGENT Tubulin disrupting agent PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials

Related Entries

Scaffolds

Parent

Cross References

Resources Reference
ChEMBL CHEMBL2105643
FDA SRS GBW044919E
PubChem 10186184
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